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General Information
Symbol
Dmel\tkv1ΔGSK.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0092484
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-tkvDN, UAS-TkvDN, UAS-tkv1ΔGSK, UAS-tkvDGSK
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A dominant negative form of the tkv1 isoform, in which the GS box and kinase domain are deleted, is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of tkv1ΔGSK.Scer\UAS in trachea generates bifurcated, abnormally shaped air sac primordiums.

Expression of tkv1ΔGSK.Scer\UAS under the control of Scer\GAL4OK6, does not result in ISNb or SNa pathfinding defects.

Flies expressing tkv1ΔGSK.Scer\UAS under the control of Scer\GAL4ptc-559.1 have smaller wings than normal with a loss of wing vein L4 and the anterior crossvein.

When expression is driven by Scer\GAL4p127 in the fusion cells disrupts fusion in 19% of the dorsal branches. Suppression of expression of hdc suggests a failure of fusion cell differentiation. When expression is driven by Scer\GAL4btl.PS a similar, though milder, phenotype results.

Flies expressing tkv1ΔGSK.Scer\UAS (carrying 3 to 4 copies of P{UAS-tkv.1ΔGSK}) under the control of Scer\GAL4A9 have small wings with partial loss of vein L4 and both cross veins. Veins L2 and L3 are closer together than normal and the triple row margin bristles are shifter more distally/posteriorly. Flies expressing higher levels of tkv1ΔGSK.Scer\UAS (carrying 6 to 8 copies of P{UAS-tkv.1ΔGSK}) under the control of Scer\GAL4A9 have very small wings that show fusion of veins L2 and L3 as well as L4 and L5. Wing discs of larvae expressing tkv1ΔGSK.Scer\UAS under the control of Scer\GAL4A9 are strongly reduced in size.

Flies expressing two copies of tkv1ΔGSK.Scer\UAS under the control of Scer\GAL4A9 show partial loss of vein L4, and vein L2 starts to merge with L3.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of tkv1ΔGSK.Scer\UAS partially suppresses the loss of thoracic bristles seen in adults expressing Vap-33-1Scer\UAS.cRa under the control of Scer\GAL4sca.PU.

The wing phenotype caused by expression of gbbScer\UAS.cKa under the control of Scer\GAL4A9 and the wing phenotype caused by expression of dppScer\UAS.cHa under the control of Scer\GAL4A9 is partially suppressed if the flies are also coexpressing tkv1ΔGSK.Scer\UAS.

Co-expression of one copy of tkv1ΔGSK.Scer\UAS partially suppresses the wing phenotype caused by scwScer\UAS.cNa or dppScer\UAS.cHa expressed under the control of Scer\GAL4A9.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
tkv1ΔGSK.Scer\UAS
tkv1ΔGSK.UAS
Name Synonyms
Secondary FlyBase IDs
    References (16)