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General Information
Symbol
Dmel\saxΔI.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0092534
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-saxΔI
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A dominant negative form of sax in which the kinase domain is deleted (stop codon after amino acid residue A261) is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of saxΔI.Scer\UAS driven by Scer\GAL4Bx-MS1096 induces extensive defects in longitudinal wing vein formation and wing patterning.

When expression is driven by Scer\GAL4p127 in the fusion cells disrupts fusion in 19% of the dorsal branches. Suppression of expression of hdc suggests a failure of fusion cell differentiation. When expression is driven by Scer\GAL4btl.PS a similar, though milder, phenotype results.

Animals expressing saxΔI.Scer\UAS under the control of Scer\GAL4A9 have small wing discs. In the adult wing, vein L5 and the posterior crossvein are lost. Vein L2 is shifted more proximally and proximal triple row bristles are replaced by more proximal costa bristles. The distance between veins L3 and L4 is normal, however, the overall shape of the wing is more "strap-like" than normal suggesting loss of peripheral tissue. Flies expressing saxΔI.Scer\UAS under the control of Scer\GAL4ptc-559.1 lack the anterior crossvein at the anterior/posterior boundary of the wing.

Flies expressing two copies of saxΔI.Scer\UAS under the control of Scer\GAL4A9 have narrower wings than wild-type which lack vein L5 and the posterior crossvein. Flies expressing one copy of saxΔI.Scer\UAS under the control of Scer\GAL4A9 have no wing patterning defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing phenotype caused by expression of gbbScer\UAS.cKa under the control of Scer\GAL4A9 is almost completely suppressed if the flies are also coexpressing saxΔI.Scer\UAS. The wing phenotype caused by expression of dppScer\UAS.cHa under the control of Scer\GAL4A9 is not suppressed if the flies are also coexpressing saxΔI.Scer\UAS.

Co-expression of one copy of saxΔI.Scer\UAS strongly suppresses the wing phenotype caused by scwScer\UAS.cNa expressed under the control of Scer\GAL4A9. Co-expression of one copy of saxΔI.Scer\UAS has no effect on the wing phenotype caused by dppScer\UAS.cHa expressed under the control of Scer\GAL4A9.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
saxΔI.Scer\UAS
saxΔI.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)