|Feature type||allele||Associated gene||Dmel\pit|
|Allele class||loss of function allele|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Homozygous animals show growth defects; larvae hatch normally and initially show healthy behaviour, although with a constant delay in development compared to wild-type. The larvae are arrested at the first larval instar stage, although they can survive for longer than 7 days. The adult precursor cells and imaginal cells do not proliferate in homozygous larvae. The midgut epithelial cells of 5 day old larvae are smaller than in wild-type third instar larvae of the same age. The level of polyploidy in their nuclei is lower than wild-type. The number of adult midgut precursor cells is smaller in these larvae than in wild-type larvae, corresponding approximately to the number in wild-type first instar rather than third instar larvae. Salivary glands are smaller than in wild-type larvae and do not incorporate BrdU, indicating a failure in DNA replication. Homozygous pit10 larvae carrying pitmod.PZ can survive to the third larval instar, although they have a delayed developmental schedule. Only a few of these larvae pupariate and adults are not produced. pit5/pit10 larvae develop normally, but with a delay. Although they pupariate, they never give rise to adults. Homozygous clones in the thorax are small and are only seen when induced late in development (at the end of the third larval instar stage). Homozygous clones in the wing imaginal discs are very small and composed of only a few cells.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Partially rescued by|
|Not rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 1 )|