Allele Dmel\sha^VB13

General Information
Symbol	Dmel\sha^VB13	Species	D. melanogaster
Name		FlyBase ID	FBal0092908
Feature type	allele	Associated gene	Dmel\sha
Also Known As	koj^VB13

Allele class	heat sensitive loss of function allele
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	heat sensitive loss of function allele (He and Adler, 2002)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: P195L. (Ren et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Ren et al., 2006) visible \| heat sensitive (He and Adler, 2002) visible \| recessive (Taylor et al., 1998) visible \| somatic clone (Ren et al., 2006)
Phenotype Manifest In
	1st posterior cell \| ventral & wing hair (Ren et al., 2006) 3rd posterior cell \| dorsal & wing hair (Ren et al., 2006) 3rd posterior cell \| dorsal & wing hair \| somatic clone (Ren et al., 2006) arista \| heat sensitive (He and Adler, 2002) wing hair (Taylor et al., 1998) wing hair \| heat sensitive (He and Adler, 2002)
Detailed Description
	Statement Reference Hairs on the dorsal surface of the centre of the E region of the wing are slightly finer and more elevated than normal in homozygous flies raised at 25^oC. Cells in homozygous clones on the dorsal surface of the centre of the E region of the wing do not produce hairs. (Ren et al., 2006) Arista laterals are shorter than normal in mutant flies and are often split. At 18^oC, the phenotype is weak in sha^VB13 hemizygotes, with less than 10% of laterals being split, while at 29^oC more than 40% of laterals are branched. The temperature sensitive period is close to when laterals initiate. sha^VB13 hemizygotes have a variable wing hair phenotype, ranging from cells that produce no wing hair, to cells that produce a number of short hairs to cells that produce a normal hair. Split wing hairs are seen, but are not as common as independent multiple hairs. The temperature sensitive period is the time of hair initiation. (He and Adler, 2002) Some cells form multiple split and shortened hairs and others have no hair at all. (Taylor et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference sha^VB13, tow[+]/tow⁷⁵⁴ has visible phenotype (Chung et al., 2007)
Phenotype Manifest In
Enhanced by
Statement Reference sha^VB13 has wing hair phenotype, enhanceable by dsh¹ (Ren et al., 2006) sha^VB13 has wing hair phenotype, enhanceable by frtz² (Ren et al., 2006) sha^VB13 has wing hair phenotype, enhanceable by fz²⁵ (Ren et al., 2006) sha^VB13 has wing hair phenotype, enhanceable by in¹ (Ren et al., 2006) sha^VB13 has wing hair phenotype, enhanceable by Vang^Tbs42 (Ren et al., 2006)
Other
Statement Reference sha^VB13, tow[+]/tow⁷⁵⁴ has wing hair \| supernumerary phenotype (Chung et al., 2007) sha^VB13, tow[+]/tow⁷⁵⁴ has wing hair phenotype (Chung et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference tow⁷⁵⁴/+ increases the number of small and multiple wing hairs seen in a sha^VB13/sha^VB13 background. (Chung et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	sha^VB13 is partially rescued by Scer\GAL4^Act.PU/sha^{Scer\UAS.T:Avic\GFP} (Ren et al., 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	koj^VB13 (He and Adler, 2002, Taylor et al., 1998, ) sha^VB13 (Ren et al., 2006, Chung et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Chung et al., 2007, Genetics 176(2): 891--903 The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. [FBrf0202398] Ren et al., 2006, Genetics 172(3): 1643--1653 The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis. [FBrf0190766] He and Adler, 2002, Dev. Genes Evol. 212(5): 218--229 The genetic control of arista lateral morphogenesis in Drosophila. [FBrf0148956] Taylor et al., 1998, Genetics 150(1): 199--210 Van gogh. A new Drosophila tissue polarity gene. [FBrf0104520]

Allele Dmel\shaVB13

Allele Dmel\sha^VB13