The co-expression of hepScer\UAS.cBa and aPKCCAAXWT.Scer\UAS under the control of Scer\GAL4Bx-MS1096 leads to moderate overgrowth and cell polarity defects in third instar larval wing discs, as compared to controls.
The increased cell proliferation observed upon expression of hepScer\UAS.cBa under the control of Scer\GAL4esg-NP5130 in the adult gut is suppressed by co-expression of either Sox21aJF02191 or kaydsRNA.Scer\UAS.
The increased cell proliferation in the adult gut expressing hepScer\UAS.cBa under the control of Scer\GAL4esg-NP5130 (using tub-gal80[ts] to limit the time of expression) is suppressed by co-expression of PEKGD5584.
The defects in ventral furrow formation seen in embryos expressing hepScer\UAS.cBa under the control of Scer\GAL4twi.PG are completely suppressed in embryos derived from bskunspecified female germline clones.
The increased tolerance of animals expressing hepScer\UAS.cBa under the control of Scer\GAL4ppl.PP to paraquat is abolished by NLazNW5/NLazNW5, with the double mutant flies showing the same sensitivity to paraquat as NLazNW5/NLazNW5 single mutants.
Expression of hepScer\UAS.cBa, under the control of Scer\GAL4ato.3.6, in a dsh1 background results in a large increase of dorsal cluster neuron axons crossing the optic chiasm, indicating a complete dominance of the hep gain of function phenotype.
Coexpression of hepScer\UAS.cBa and Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.PI results in eye/antennal imaginal disc clones results in the invasion of the disc cells into the ventral nerve cord and regions of the brain.
When hepScer\UAS.cBa is coexpressed with one copy of Traf1EP578, driven by Scer\GAL4GMR.PF, the number of ommatidia and the size of the compound eye are reduced to similar levels seen when two copies of Traf1EP578 are expressed.