FB2025_02 , released April 17, 2025
Allele: Dmel\fzUAS.cZa
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General Information
Symbol
Dmel\fzUAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhang
FlyBase ID
FBal0092978
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
Carried in Construct
P{UAS-fz.Z}
Also Known As
UAS-fz, UAS-frizzled, UAS.fz
Key Links
Transgenic product class
cDNA
(Zhang and Carthew, 1998)
wild_type
(Zhang and Carthew, 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhang and Carthew, 1998)
wild_type
(Zhang and Carthew, 1998)
Mutagen
in vitro construct
(Zhang and Carthew, 1998)
Progenitor genotype
Carried in construct
P{UAS-fz.Z}
Cytology
Description

cDNA sequence nucleotides 374-2360 (FBrf0050626), which includes the entire open reading frame, is expressed from UASt regulatory sequences. Contains 224 nucleotides of 5' UTR.

(Zhang and Carthew, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fzScer\UAS.cZa, Scer\GAL4en-e16E embryos lose type 1 denticles. This is seen in all embryos, although at times, one or two segments remain unaffected.

      (Lecourtois et al., 2001)

      When expression is driven by Scer\GAL469B, wing margin structures are properly patterned but the polarity of hairs and margin bristles is perturbed, with bristles pointing straight our from the wing margin, instead of being angled towards the posterior. Interior wing hairs are also affected. When expression is driven by Scer\GAL4hs.2sev, ommatidia are misoriented and the two chiral forms are not regularly segregated into the dorsal and ventral halves of the eye. This is similar to the fz loss of function phenotype. Has no effect on wing phenotypes caused by fzScer\UAS.N. When expression is driven by Scer\GAL4ptc-559.1 in embryos, denticle belt phenotypes include fusions and mirror image duplications, reminiscent of wg weak loss of function alleles.

      (Zhang and Carthew, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL469B, fzUAS.cZa has abnormal planar polarity phenotype, non-suppressible by wgl-17

      (Zhang and Carthew, 1998)
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4ptc-559.1/fzUAS.cZa is a non-enhancer of abnormal planar polarity phenotype of dsUAO71

      (Repiso et al., 2010)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL469B, fzUAS.cZa has wing margin bristle phenotype, non-suppressible by wgl-17

      (Zhang and Carthew, 1998)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      fzUAS.cZa/Scer\GAL4e22c is a non-suppressor of phenotype of wgPE2

      (Moline et al., 2000)

      Scer\GAL4prd.RG1/fzUAS.cZa is a non-suppressor of phenotype of wgPE2

      (Moline et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of fzScer\UAS.cZa in dsUAO71 larvae under the control of Scer\GAL4ptc-559.1 does not affect denticle belt polarity.

      (Repiso et al., 2010)

      The wing bristle polarity phenotype caused by expression of fzScer\UAS.cZa using Scer\GAL469B cannot be suppressed by wgl-17. Has no effect on wing phenotypes caused by fz2Scer\UAS.N.

      (Zhang and Carthew, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fzScer\UAS.cZa
      (Casal et al., 2006)
      fzUAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zhang
      (Zhang and Carthew, 1998)
      Secondary FlyBase IDs
        References (8)