ena²³ zygotic/maternal mutant embryos display a wavy leading edge during dorsal closure, with defects in leading edge cell shape, a reduced rate of zippering and deep and persistent segmental grooves. Approximately 90% of ena²³ zygotic mutants exhibit virtually wild-type cuticles, whereas 8% display head holes.

(Choi et al., 2011)

Cultured primary neurons derived from ena²³ and ena^GC1/ena²³ embryos show a significant reduction in the number of filopodia compared to control neurons. Mean filopodium length is reduced compared to wild type in these neurons.

(Gonçalves-Pimentel et al., 2011)

24% of eggs derived from females carrying homozygous germline clones show a "dumpless" phenotype. Egg chambers in females with homozygous germline clones have defects in the cytoplasmic filaments (the bundled cytoplasmic actin filaments extending from the cortex to nuclei). No defects in ring canal formation or growth are seen in mutant egg chambers. Some egg chambers contain multinucleate nurse cells. Homozygous follicle cell clones do not usually cause significant disruptions in either epithelial organisation or in the assembly of cortical actin into follicle cells adherens junctions in stage 2-7 egg chambers. However, in later egg chambers, clones with reduced cortical actin and disruptions in epithelial integrity are seen.

(Gates et al., 2009)

Leading edge cells in embryos that are maternally and zygotically mutant for ena show a large decrease in average lamellipodial area and a striking decrease in filopodial number.

(Homem and Peifer, 2009)

Homozygous clones that encompass the morphogenetic furrow do not result in a defect in cell constriction in the morphogenetic furrow.

(Corrigall et al., 2007)

ena²³/ena^GC1 embryos have reduced longitudinal axons in the central nervous system. 74% of zygotic ena²³ mutant embryos have a wild-type cuticle, while 21% show misalignment/puckering along the dorsal midline. Mature embryos that are both maternally and zygotically mutant for ena (ena²³/ena^GC1 embryos derived from females with homozygous ena²³ germlines) proceed through gastrulation normally and have normal epithelial integrity. Segmental grooves are deeper than normal in these embryos and persist long after they should have regressed. The leading edge during dorsal closure is often uneven. Most of the embryos fail in head involution. Cells that should lead head involution appear to constrict far more than in wild type, nearly severing the head from the thorax. Mature embryos that are both maternally and zygotically mutant for ena (ena²³/ena^GC1 embryos derived from females with homozygous ena²³ germlines) show defects in the cuticle; 10% have a dorsal pucker, 37% have a hole in the head, 15% have both a dorsal pucker and a hole in the head and 28% have a large ventral hole.

(Gates et al., 2007)

Single cell γ neuron mutant clones in the mushroom body show drastic axon growth defects.

(Ng and Luo, 2004)

Homozygous embryos do not show midline crossing errors by axons in the central nervous system.

(Wills et al., 2002)

Mutant follicle cell clones lose cortical actin filaments from apical, basal and lateral sites.

(Baum and Perrimon, 2001)

96% of ISNb axons show a bypass phenotype in homozygous embryos.

(Wills et al., 1999)

Lethal in combination with ena^GC1.

(Ahern-Djamali et al., 1998)

ena²³ has cell shape defective phenotype, enhanceable by pyd[+]/pyd^B12

(Choi et al., 2011)

ena²³ has cell shape defective phenotype, enhanceable by pyd^ex180/pyd[+]

(Choi et al., 2011)

ena²³ has cell shape defective phenotype, enhanceable by cno^R2/cno[+]

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of cell shape defective phenotype of cno^R2

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of visible phenotype of fj^N7

(Buckles et al., 2001)

ena²³/ena[+] is a suppressor of cell migration defective phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of cell migration defective phenotype of Rho1^UAS.cMa, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of cell migration defective phenotype of Scer\GAL4^ptc-559.1, hep^UAS.cUa

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of neuroanatomy defective phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}

(Matusek et al., 2008)

ena²³ has embryo | dorsal closure stage phenotype, enhanceable by pyd[+]/pyd^B12

(Choi et al., 2011)

ena²³ has embryonic leading edge cell phenotype, enhanceable by pyd[+]/pyd^B12

(Choi et al., 2011)

ena²³ has ventral head epidermis phenotype, enhanceable by pyd[+]/pyd^B12

(Choi et al., 2011)

ena²³ has embryonic head phenotype, enhanceable by pyd[+]/pyd^B12

(Choi et al., 2011)

ena²³ has embryo | dorsal closure stage phenotype, enhanceable by pyd^ex180/pyd[+]

(Choi et al., 2011)

ena²³ has embryonic leading edge cell phenotype, enhanceable by pyd^ex180/pyd[+]

(Choi et al., 2011)

ena²³ has ventral head epidermis phenotype, enhanceable by pyd^ex180/pyd[+]

(Choi et al., 2011)

ena²³ has embryonic head phenotype, enhanceable by pyd^ex180/pyd[+]

(Choi et al., 2011)

ena²³ has embryo | dorsal closure stage phenotype, enhanceable by cno^R2/cno[+]

(Choi et al., 2011)

ena²³ has embryonic leading edge cell phenotype, enhanceable by cno^R2/cno[+]

(Choi et al., 2011)

ena²³ has ventral head epidermis phenotype, enhanceable by cno^R2/cno[+]

(Choi et al., 2011)

ena²³ has embryonic head phenotype, enhanceable by cno^R2/cno[+]

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryo | dorsal closure stage phenotype of cno^R2

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic leading edge cell phenotype of cno^R2

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of ventral head epidermis phenotype of cno^R2

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic head phenotype of cno^R2

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryo | dorsal closure stage phenotype of pyd^B12

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic leading edge cell phenotype of pyd^B12

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of ventral head epidermis phenotype of pyd^B12

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic head phenotype of pyd^B12

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryo | dorsal closure stage phenotype of pyd^ex180

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic leading edge cell phenotype of pyd^ex180

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of ventral head epidermis phenotype of pyd^ex180

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of embryonic head phenotype of pyd^ex180

(Choi et al., 2011)

ena²³/ena[+] is an enhancer of joint phenotype of fj^N7

(Buckles et al., 2001)

ena²³/ena[+] is a suppressor of wing disc phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of wing disc phenotype of Rho1^UAS.cMa, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of wing disc phenotype of Scer\GAL4^ptc-559.1, hep^UAS.cUa

(Rudrapatna et al., 2014)

ena²³/ena[+] is a suppressor of neuropil | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

ena²³/ena[+] is a suppressor of fascicle | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

ena²³/ena[+] is a suppressor of commissure | embryonic stage phenotype of DAAM^C.UASp/DAAM^{C.Scer\UAS.P\T}, Scer\GAL4^elav-C155

(Matusek et al., 2008)

ena²³/ena[+] is a non-suppressor of intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of mir-8^Δ

(Lu et al., 2014)

ena²³/ena[+] is a non-suppressor of axon | embryonic stage phenotype of mir-8^Δ

(Lu et al., 2014)

Arpc1¹, ena²³/ena[+] has filopodium phenotype

(Gonçalves-Pimentel et al., 2011)

chic²²¹, ena²³/ena[+] has filopodium phenotype

(Gonçalves-Pimentel et al., 2011)

chic^05205a, ena²³/ena[+] has filopodium phenotype

(Gonçalves-Pimentel et al., 2011)

DAAM^Ex68, ena²³/ena[+] has filopodium phenotype

(Gonçalves-Pimentel et al., 2011)