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General Information
Symbol
Dmel\dshhs.sev.B
Species
D. melanogaster
Name
FlyBase ID
FBal0093042
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sev-Dsh
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of dsh cDNA is driven by an Hsp70 promoter and sev enhancer.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of dshhs.sev.B results in ommatidial orientation defects in the eye.

Expression of dshhs.sev.B results in 42% of adult ommatidia having a symmetrical arrangement.

Ommatidial arrangement is disrupted due to overactivation of planar polarity signalling.

Eyes of flies raised at 29oC show disruption of ommatidial arrangement with random or no chirality and misrotations of single ommatidia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

dshhs.sev.B has planar polarity defective phenotype, suppressible by kay1/kay[+]

dshhs.sev.B has planar polarity defective phenotype, suppressible by kayED6315/kay[+]

dshhs.sev.B has planar polarity defective phenotype, suppressible by Jra1/Jra[+]

dshhs.sev.B has planar polarity defective phenotype, suppressible by JraIA109/Jra[+]

dshhs.sev.B has planar polarity defective phenotype, suppressible by hep[+]/hepr75

dshhs.sev.B has planar polarity defective phenotype, suppressible by msn[+]/msn102

dshhs.sev.B has planar polarity defective phenotype, suppressible by msn172/msn[+]

dshhs.sev.B has planar polarity defective phenotype, suppressible by bsk2/bsk[+]

NOT suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

dshhs.sev.B has ommatidium phenotype, enhanceable by ex[+]/exe1

dshhs.sev.B has eye phenotype, enhanceable by ex[+]/exe1

dshhs.sev.B has ommatidium phenotype, enhanceable by DlRevF10/Dl[+]

dshhs.sev.B has ommatidium phenotype, enhanceable by N[+]/N264-39

NOT Enhanced by
Statement
Reference

dshhs.sev.B has phenotype, non-enhanceable by rinunspecified

dshhs.sev.B has ommatidium phenotype, non-enhanceable by dock3

Suppressed by
Statement
Reference

dshhs.sev.B has ommatidium phenotype, suppressible by Df(2L)ED793/+

dshhs.sev.B has ommatidium phenotype, suppressible by +/Df(3R)ED5644

dshhs.sev.B has ommatidium phenotype, suppressible by kay1/kay[+]

dshhs.sev.B has ommatidium phenotype, suppressible by kayED6315/kay[+]

dshhs.sev.B has ommatidium phenotype, suppressible by Jra1/Jra[+]

dshhs.sev.B has ommatidium phenotype, suppressible by JraIA109/Jra[+]

dshhs.sev.B has ommatidium phenotype, suppressible | partially by aopyan-XE18/aop[+]

dshhs.sev.B has ommatidium phenotype, suppressible | partially by aop[+]/aope2d

dshhs.sev.B has ommatidium phenotype, suppressible by Df(1)H6/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(1)G24/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(2L)flp170B/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(3R)crb87-4/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(2L)b80e3/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(3R)p13/+

dshhs.sev.B has ommatidium phenotype, suppressible by Df(2L)b87e25/+

dshhs.sev.B has ommatidium phenotype, suppressible by hep[+]/hepr75

dshhs.sev.B has ommatidium phenotype, suppressible by msn[+]/msn102

dshhs.sev.B has ommatidium phenotype, suppressible by msn172/msn[+]

dshhs.sev.B has ommatidium phenotype, suppressible by bsk2/bsk[+]

dshhs.sev.B has phenotype, suppressible by Rho1k07903

dshhs.sev.B has phenotype, suppressible by bsk2

dshhs.sev.B has phenotype, suppressible by hepr75

dshhs.sev.B has phenotype, suppressible by Jra1

dshhs.sev.B has phenotype, suppressible by JraIA109

NOT suppressed by
Statement
Reference

dshhs.sev.B has phenotype, non-suppressible by rinunspecified

dshhs.sev.B has ommatidium phenotype, non-suppressible by dock3

dshhs.sev.B has phenotype, non-suppressible by Cdc423

dshhs.sev.B has phenotype, non-suppressible by Ras85De2F

dshhs.sev.B has phenotype, non-suppressible by arm2

dshhs.sev.B has phenotype, non-suppressible by arm8

dshhs.sev.B has phenotype, non-suppressible by panER1

dshhs.sev.B has phenotype, non-suppressible by rl10

dshhs.sev.B has phenotype, non-suppressible by wgl-17

Additional Comments
Genetic Interactions
Statement
Reference

The dshhs.sev.B gain-of-function planar cell polarity (PCP)-phenotype is markedly suppressed by the expression of CG15283GD13108 via Scer\GAL4hs.2sev.

One copy of kay1, kayED6315, Jra1 or JraIA109 suppresses the formation of symmetrical ommatidia that is seen in animals expressing dshhs.sev.B.

One copy of aopyan-XE18 or aope2d partially suppresses the formation of symmetrical ommatidia that is seen in animals expressing dshhs.sev.B.

The eye phenotype seen in dshhs.sev.B flies is dominantly enhanced by the addition of exe1 due to an increase in unscorable ommatidia (missing one or more photoreceptors.

The tissue polarity phenotype of flies carrying dshhs.sev.B is dominantly enhanced by N264-39 or DlRevF10; the percentage of symmetrical ommatidia containing an R3/R3 pair in the normal R3/R4 position is increased.

The ommatidial polarity defects seen in dshhs.sev.B flies grown at 29oC can be dominantly suppressed by the addition of hepr75, msn102, msn172, bsk2, Df(1)H6, Df(1)G24, Df(2L)flp170B, Df(3R)crb87-4, Df(2L)b80e3, Df(3R)p13, Df(3R)crb-F89-4 and Df(2L)b87e25. Between 70-90% of ommatidia are in their correct polarity, compared with 55% in dshhs.sev.B alone. The ommatidial polarity defects seen in dshhs.sev.B flies grown at 29oC are not suppressed by the addition of dock3.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
dshhs.sev.B
Name Synonyms
Secondary FlyBase IDs
    References (10)