Allele Dmel\dm^Scer\UAS.cZa

General Information
Symbol	Dmel\dm^Scer\UAS.cZa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Zaffran	FlyBase ID	FBal0093088
Feature type	allele	Associated gene	Dmel\dm

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms embryonic/larval fat body heat sensitive
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Zaffran et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of a dm cDNA. (Zaffran et al., 1998)
Carried in construct	P{UAS-dm.Z} (Berry and Baehrecke, 2007, Perrin et al., 2003, Goodliffe et al., 2005, Jiao et al., 2001, Orian et al., 2003, Britton et al., 2002, Xue and Noll, 2002, Colombani et al., 2005, Hennig and Neufeld, 2002, Moberg et al., 2004, Prober and Edgar, 2002, Duman-Scheel et al., 2004, Pierce et al., 2004, Quinn et al., 2004, Prober and Edgar, 2000, de la Cova et al., 2004, Reis and Edgar, 2004, Frei et al., 2005, Shcherbata et al., 2004, Bateman and McNeill, 2004, Tapon et al., 2001, Zaffran et al., 1998, Pielage et al., 2003, Johnston et al., 1999, Parker, 2006, Betschinger et al., 2006, Nolo et al., 2006, Li and Baker, 2007, Secombe et al., 2007, Simcox et al., 2008, Mortimer and Moberg, 2007, Reddy and Irvine, 2011, Khan et al., 2009, Steiger et al., 2008, Montero et al., 2008, Steiger et al., 2008, Wang and Huang, 2009, Goodliffe et al., 2007, Ziosi et al., 2010, Neto-Silva et al., 2010, Furrer et al., 2010, Marinho et al., 2011, Mitchell et al., 2010, Li et al., 2010, Kawamori and Yamaguchi, 2011, Orian et al., 2007, Li et al., 2010, Becam et al., 2011, Unhavaithaya and Orr-Weaver, 2012, Xu et al., 2008, Datar et al., 2006, Benassayag et al., 2005, Herranz et al., 2010, Daneshvar et al., 2013, Wang et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	cell growth defective, with Scer\GAL4^Aug21 (Colombani et al., 2005) cell growth defective \| cell non-autonomous \| somatic clone, with Scer\GAL4^Act5C.PP (de la Cova et al., 2004) cell growth defective \| somatic clone, with Scer\GAL4^Act5C.PP (de la Cova et al., 2004) decreased cell number \| adult stage, with Scer\GAL4^en-e16E (Wang et al., 2008) endomitotic cell cycle defective, with Scer\GAL4^moody.PS (Unhavaithaya and Orr-Weaver, 2012) endomitotic cell cycle defective \| somatic clone \| third instar larval stage, with Scer\GAL4^Act5C.PP (Datar et al., 2006) increased cell death, with Scer\GAL4^ap-md544 (Montero et al., 2008, Benassayag et al., 2005) increased cell death, with Scer\GAL4^dpp.blk1 (de la Cova et al., 2004) increased cell death, with Scer\GAL4^GMR.PF (Montero et al., 2008) increased cell death, with Scer\GAL4^αTub84B.PC (de la Cova et al., 2004) increased cell death \| cell non-autonomous, with Scer\GAL4^dpp.blk1 (de la Cova et al., 2004) increased cell death \| cell non-autonomous \| somatic clone, with Scer\GAL4^Act5C.PP (de la Cova et al., 2004) increased cell death \| somatic clone, with Scer\GAL4^Act5C.PP (Benassayag et al., 2005) increased cell death \| somatic clone, with Scer\GAL4^hh.PU (Ziosi et al., 2010) increased cell number \| third instar larval stage, with Scer\GAL4^repo.PU (Reddy and Irvine, 2011) increased cell size, with Scer\GAL4^GMR.PF (Quinn et al., 2004, Secombe et al., 2007) increased cell size, with Scer\GAL4^ptc-559.1 (Marinho et al., 2011) increased cell size \| adult stage, with Scer\GAL4^en-e16E (Wang et al., 2008) increased cell size \| somatic clone, with Scer\GAL4^Act5C.PI (Marinho et al., 2011) increased cell size \| somatic clone, with Scer\GAL4^Act5C.PP (Prober and Edgar, 2002, Bateman and McNeill, 2004, Benassayag et al., 2005) increased cell size \| somatic clone, with Scer\GAL4^αTub84B.PL (Grewal et al., 2005) lethal, with Scer\GAL4^da.G32 (Daneshvar et al., 2013) lethal \| heat sensitive, with Scer\GAL4^dm-PG45 (Benassayag et al., 2005) lethal \| larval stage, with Scer\GAL4^da.G32 (Khan et al., 2009) mitotic cell cycle defective, with Scer\GAL4^Act5C.PP (Reis and Edgar, 2004) mitotic cell cycle defective \| somatic clone, with Scer\GAL4^Act5C.PP (Benassayag et al., 2005) size defective \| adult stage, with Scer\GAL4^GMR.PF (Xu et al., 2008) size defective \| somatic clone, with Scer\GAL4^Act5C.PI (Marinho et al., 2011) small body \| larval stage, with Scer\GAL4^da.G32 (Khan et al., 2009) visible, with Scer\GAL4^ap-md544 (Furrer et al., 2010) visible, with Scer\GAL4^GMR.PF (Secombe et al., 2007, Steiger et al., 2008, Montero et al., 2008, Furrer et al., 2010, Li et al., 2010) visible \| adult stage, with Scer\GAL4^GMR.PF (Xu et al., 2008)
Phenotype Manifest In
	cell, with Scer\GAL4^Act5C.PP (Johnston et al., 1999) cell, with Scer\GAL4^bbg-C96 (Johnston et al., 1999) cell, with Scer\GAL4^en-e16E (Johnston et al., 1999) cell cycle, with Scer\GAL4^Act5C.PP (Johnston et al., 1999) cell cycle, with Scer\GAL4^bbg-C96 (Johnston et al., 1999) dorsal-ventral compartment boundary of the wing \| third instar larval stage, with Scer\GAL4^sd-SG29.1 (Becam et al., 2011) embryonic/larval brain \| third instar larval stage, with Scer\GAL4^repo.PU (Reddy and Irvine, 2011) embryonic/larval fat body \| somatic clone \| third instar larval stage, with Scer\GAL4^Act5C.PP (Datar et al., 2006) embryonic/larval glial cell \| third instar larval stage, with Scer\GAL4^repo.PU (Reddy and Irvine, 2011) eye, with Scer\GAL4^GMR.PF (Quinn et al., 2004, Secombe et al., 2007, Steiger et al., 2008, Steiger et al., 2008, Montero et al., 2008, Li et al., 2010, Xu et al., 2008) eye disc, with Scer\GAL4^GMR.PF (Quinn et al., 2004, Montero et al., 2008) eye disc \| third instar larval stage, with Scer\GAL4^repo.PU (Reddy and Irvine, 2011) eye photoreceptor cell, with Scer\GAL4^GMR.PF (Secombe et al., 2007) follicle cell & nucleus \| somatic clone, with Scer\GAL4^Act5C.PP (Shcherbata et al., 2004) larval salivary gland & nucleolus, with Scer\GAL4^en-e16E (Grewal et al., 2005) mitotic cell cycle, with Scer\GAL4^Act5C.PP (Reis and Edgar, 2004) mitotic cell cycle \| somatic clone, with Scer\GAL4^Act5C.PP (Prober and Edgar, 2002) nucleolus, with Scer\GAL4^en-e16E (Grewal et al., 2005) nucleolus, with Scer\GAL4^ptc-559.1 (Grewal et al., 2005, Marinho et al., 2011) nucleolus, with Scer\GAL4^sca-109-68 (Kawamori and Yamaguchi, 2011) nucleus, with Scer\GAL4^ptc-559.1 (Grewal et al., 2005, Marinho et al., 2011) nucleus, with Scer\GAL4^sca-109-68 (Kawamori and Yamaguchi, 2011) ommatidium, with Scer\GAL4^GMR.PF (Quinn et al., 2004, Secombe et al., 2007, Steiger et al., 2008, Steiger et al., 2008, Montero et al., 2008, Furrer et al., 2010) pigment cell, with Scer\GAL4^GMR.PF (Steiger et al., 2008) posterior scutellar bristle, with Scer\GAL4^sca-109-68 (Kawamori and Yamaguchi, 2011) ring canal, with Scer\GAL4^Aug21 (Colombani et al., 2005) salivary gland \| somatic clone, with Scer\GAL4^Act5C.PP (Furrer et al., 2010) subperineurial glial cell, with Scer\GAL4^moody.PS (Unhavaithaya and Orr-Weaver, 2012) trichogen cell, with Scer\GAL4^sca-109-68 (Kawamori and Yamaguchi, 2011) ventral nerve cord primordium, with Scer\GAL4^rho.PU (Orian et al., 2007) wing, with Scer\GAL4^ap-md544 (Furrer et al., 2010) wing, with Scer\GAL4^αTub84B.PC (de la Cova et al., 2004) wing \| posterior, with Scer\GAL4^en-e16E (Wang et al., 2008) wing disc, with Scer\GAL4^ap-md544 (Montero et al., 2008, Benassayag et al., 2005) wing disc \| somatic clone, with Scer\GAL4^Act5C.PP (Furrer et al., 2010, Benassayag et al., 2005)
Detailed Description
	Statement Reference Overexpression of dm[Scer\UAS.cZa] in subperineurial glia, under the control of Scer\GAL4[moody.PS] results in an increase in polyploidy in these cells. (Unhavaithaya and Orr-Weaver, 2012) Late third instar wing discs expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[sd-SG29.1] have disturbed dorsal-ventral (DV) boundaries compared to controls. (Becam et al., 2011) Over-expression of dm[Scer\UAS.cZa] using Scer\GAL4[sca-109-68] increases the nuclear and nucleolar size of the posterior scutellar shaft cells. (Kawamori and Yamaguchi, 2011) Eye disc clones expressing dm[Scer\UAS.cZa] are significantly larger than control clones as a result of increased cell size. Salivary glands expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[ptc-559.1] have dramatically increased nuclear, nucleolar and overall cell size. Nucleoli display slightly less compact packaging with closely intermingled fibrillar and granular components. (Marinho et al., 2011) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[repo.PU] slightly increases glial cell numbers in the third instar larval eye disc and brain. (Reddy and Irvine, 2011) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] results in flies with larger ommatidia than normal. Clones in the wing disc expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] are increased in size compared to control clones. Clones in the larval salivary glands expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] result in excessive endoreplication. (Furrer et al., 2010) Mosaic dm[Scer\UAS.cZa]-Scer\GAL4[hh.PU] clones tend to die and do not overgrow compared to wild-type twin clones. (Ziosi et al., 2010) Many animals expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[da.G32] hatch into viable larvae, however these larvae fail to grow and after approximately 3 days, they die as small larvae. These larvae behave as wandering third instars, and often die attached to the side of the vial. (Khan et al., 2009) Flies expressing three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] have larger eyes than normal which contain larger than normal ommatidia. The eyes have a rough exterior. Third larval instar eye discs expressing three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] show a small, but statistically significant, increase in apoptotic cells posterior to the morphogenetic furrow compared to controls. Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] results in increased apoptosis in the domain of Scer\GAL4[ap-md544] expression. (Montero et al., 2008) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] in primary cell cultures of cells derived from embryos does not produce very large clones of cells. (Simcox et al., 2008) Expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] results in apoptosis, resulting in a disturbance of the internal architecture of the adult eye and reducing the number of pigment cells it contains. The average ommatidial size is increased in these animals compared to controls. (Steiger et al., 2008) Expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] results in apoptosis in the eye and an increase in average ommatidial size compared to controls. (Steiger et al., 2008) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[en-e16E] has no effect on the overall size of the posterior wing compartment, but cell number is reduced and the size of the cells is increased. (Wang et al., 2008) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] results in an increase in eye size. (Xu et al., 2008) Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^fkh.PH does not prevent the salivary gland degradation that is seen during the pupal stage in normal development. (Berry and Baehrecke, 2007) Cells that are expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^en-e16E engulf adjacent apoptotic wild-type cells. (Li and Baker, 2007) Expression of dm[Scer\UAS.cZa] in the developing tracheal system under the control of Scer\GAL4[btl.PS] does not affect tracheal development. (Mortimer and Moberg, 2007) Stage 9 embryos expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[rho.PU] show neuroblast hyperplasia and elevated mitotic activity in the developing neuroectoderm. (Orian et al., 2007) Flies expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF have eyes that are larger than normal and which have a rough appearance due to disorganised ommatidia. Each ommatidium is enlarged 33% compared to wild type, and this results in a disruption of the ommatidial array. Eye discs expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF do not show defects in neuronal differentiation, and the pattern of cells in S phase and apoptosis is wild type. The photoreceptor cells are dramatically enlarged compared to wild type. (Secombe et al., 2007) Clones of cells in the third larval instar fat body expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] contain more DNA than wild-type controls. (Datar et al., 2006) Females expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[dm-PG45] show reduced viability at 18 and 22[o]C (with greater survival at 18[o]C) and do not survive to adulthood at 26[o]C. Clones in the wing disc expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] show an increase in cell size and a strong reduction in the fraction of cells in G[[1]] with a concomitant increase in cells in S or G[[2]] phase compared to controls. The clones show high levels of apoptosis. Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] induces apoptosis in the wing disc. (Benassayag et al., 2005) Expression of dm^Scer\UAS.cZa in the ring gland using Scer\GAL4^P0206 induces autonomous growth. (Colombani et al., 2005) When dm^Scer\UAS.cZa is driven by Scer\GAL4^Act5C.PP in clones, growth stimulation is seen. Mitochondrial activity is not stimulated. When mitochondrial inhibitors are used a slight increase in growth stimulation is seen in fat cells. Hypoxia treatment has no effect. (Frei et al., 2005) dm^Scer\UAS.cZa overexpressing cells, under the regulation of Scer\GAL4^en-e16E have enlarged nucleoli compared with surrounding wild-type cells. Overexpression of dm^Scer\UAS.cZa in salivary gland cells under the regulation of Scer\GAL4^ptc-559.1 leads to a loss of secretory vesicles, and an enlarged nucleus and nucleolus. Although dm^Scer\UAS.cZa expression increases ploidy in these cells, the ratio of nucleolar volume to DNA content is increased approximately sixfold by dm. dm^Scer\UAS.cZa-expressing cells have a dense cytoplasm, characterised by an increase in the number and density of ribosomes and polysomes. In addition, an extensive network of rough endoplasmic reticulum is observed specifically in these cells, compared to wild-type. dm^Scer\UAS.cZa clones generated in the wing disc using the MARCM GAL repressor/activator system, undergo an increase in cell size compared to wild-type. Overexpression of dm^Scer\UAS.cZa also promotes G1/S phase transitions in wing disc cells, leading to a decreased population of G1 cells and an increase in the proportion of S/G2 phase cells. (Grewal et al., 2005) Clones in the eye disc expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^Act5C.PP result in larger cells than normal. (Bateman and McNeill, 2004) Somatic clones expressing dm^Scer\UAS.cZa (driven by Scer\GAL4^Act5C.PP, in the wing disc) are significantly larger than controls. Sibling clones next to these clones are smaller than controls elsewhere. However the A-P compartment boundary protects cells in the posterior compartment from cell competition induced by dm^Scer\UAS.cZa in the anterior compartment. Wing discs with clones show an increased level of apoptosis. dm^Scer\UAS.cZa driven by Scer\GAL4^dpp.blk1 in the wing disc, leads in apoptosis. When somatic clones expressing dm^Scer\UAS.cZa is driven by Scer\GAL4^αTub84B.PC or Scer\GAL4^dpp.blk1, wing discs and adult wings are the same size as controls. When dm^Scer\UAS.cZa is ubiquitously driven in the wing disc by Scer\GAL4^αTub84B.PC wings overgrow. Mutant wings (and mutant wing discs) are about 20% larger than controls and weigh about 15% more than controls. When 'wild-type' clones are made in wings ubiquitously expressing dm^Scer\UAS.cZa, the clones usually die, however the wing discs and adult wings are reduced in size compared to dm^Scer\UAS.cZa expressing discs and wings with no clones. (de la Cova et al., 2004) Expression of dm^Scer\UAS.cZa when driven by Scer\GAL4^C96 prevents the block to G₁-S phase transition in the nonproliferating cells (ZNC) of third instar larvae. (Duman-Scheel et al., 2004) Nuclei in dm^Scer\UAS.cZa; Scer\GAL4^Act5C.PP somatic clones in the 2nd or 3rd instar larval fat body have significantly higher DNA content (assayed by DAPI fluorescence) than neighbouring cells. The magnitude of this difference increases with age. Unlike wild-type, significant levels of endoreplication occur at the wandering third instar stage in dm^Scer\UAS.cZa; Scer\GAL4^ptc-559.1 salivary glands & dm^Scer\UAS.cZa; Scer\GAL4^Adh.PF fat bodies. (Assayed by BrdU incorporation). (Pierce et al., 2004) Cells are larger than wild-type posterior to the morphogenetic furrow in dm^Scer\UAS.cZa; Scer\GAL4^GMR.PF third instar larval eye discs, and the bands of cells in S phase band and in mitosis posterior to the furrow are thinner than in wild type. The resulting adults have larger adult ommatidia and oversized eyes. (Quinn et al., 2004) In somatic clones of dm^Scer\UAS.cZa; Scer\GAL4^Act5C.PP cells in the ovarian follicle cells, nuclei become enlarged. FACS profiles of DNA content in follicle cell populations containing these somatic clones show a 32n population not present in wild-type. However, amplification at specific loci (seen after stage 10B in wild-type) occurs normally in these enlarge nuclei. (Shcherbata et al., 2004) Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^Act5C.PP in clones of cells does not promote cell growth under starvation conditions, but does promote DNA replication. Animals expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^Adh.PF or Scer\GAL4^en-e16E are not starvation sensitive. (Britton et al., 2002) Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^Act5C.PP in wing disc cells results in an increase in cell size compared to controls. The proportion of cells in G₁ is decreased compared to controls. Clones expressing dm^Scer\UAS.cZa under the control of Scer\GAL4^Act5C.PP are not visibly round, do not generate ectopic folds and do not bulge out of the epithelium. (Prober and Edgar, 2002) Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^ey.PH has no effect on eye size. (Tapon et al., 2001) Clones expressing both dm^Scer\UAS.cZa and Ras85D^N17.Scer\UAS under the control of Scer\GAL4^Act5C.PP in clones in the imaginal discs have a similar cell size and cell cycle profiles as those of cells expressing dm^Scer\UAS.cZa alone under the control of Scer\GAL4^Act5C.PP. The elongated doubling time of cells expressing Ras85D^N17.Scer\UAS under the control of Scer\GAL4^Act5C.PP is partially rescued by co-expression of dm^Scer\UAS.cZa. (Prober and Edgar, 2000) When expression is driven by Scer\GAL4^Act5C.PP or Scer\GAL4^en-e16E in clones in the wing disc cell size is increased. The increase in cell size is not accompanied by overgrowth of the wing, indicating that patterning mechanisms are not altered. Cell cycle phasing, but not cell cycle rate is altered. When expression is driven by Scer\GAL4^C96 ectopic S phases occur in the ZNC of the wing disc, showing a block in cell cycle arrest. This block affects only the G1 arrest, G2 arrest proceeds normally. The non-arrested cells also show a block in their growth arrest. (Johnston et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by ago⁴/ago[+] (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by Hcf^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Furrer et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by lid^{C1296A.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by lid^{JmjC.mut.Scer\UAS.P\T}/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Secombe et al., 2007, Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by lid^{ΔARID.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by lid^{ΔPHD1.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, enhanceable by Scer\GAL4^GMR.PF/lid^{Scer\UAS.P\T.cSa}/Scer\GAL4^GMR.PF (Secombe et al., 2007, Li et al., 2010) Scer\GAL4^repo.PU, dm^Scer\UAS.cZa has increased cell number \| third instar larval stage phenotype, enhanceable by yki^{Scer\UAS.cOa.T:SV5\V5}/Scer\GAL4^repo.PU (Reddy and Irvine, 2011)
NOT Enhanced by
Statement Reference Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by CycE^AR95 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by dap^2X10 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by Df(3L)H99 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by E2f^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by lid^17.1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by lid^{ΔC5HC2.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by lid^{ΔJmjN.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-enhanceable by lid^{ΔPHD3.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010)
Suppressed by
Statement Reference Scer\GAL4^Act5C.PI, dm^Scer\UAS.cZa has increased cell size \| somatic clone phenotype, suppressible \| partially by Scer\GAL4^Act5C.PI/vito^GD10890 (Marinho et al., 2011) Scer\GAL4^Act5C.PI, dm^Scer\UAS.cZa has size defective \| somatic clone phenotype, suppressible by Scer\GAL4^Act5C.PI/vito^GD10890 (Marinho et al., 2011) Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has increased cell death \| somatic clone \| cell non-autonomous phenotype, suppressible by Df(3L)X14 (de la Cova et al., 2004) Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has mitotic cell cycle defective phenotype, suppressible by Dp^a1/Dp^a2 (Reis and Edgar, 2004) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has increased cell death phenotype, suppressible by Df(3L)G870/+ (Montero et al., 2008) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has increased cell death phenotype, suppressible by Df(3L)H99 (Montero et al., 2008) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has visible phenotype, suppressible \| partially by Hcf^{dsRNA.IR-3.Scer\UAS}, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has visible phenotype, suppressible \| partially by Hcf^GD4353, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has visible phenotype, suppressible by Gcn5^GD11218, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has visible phenotype, suppressible by Scer\GAL4^ap-md544/ash2^GD1374 (Furrer et al., 2010) Scer\GAL4^da.G32, dm^Scer\UAS.cZa has lethal phenotype, suppressible \| partially by mir-308^Scer\UAS.cDa/Scer\GAL4^da.G32 (Daneshvar et al., 2013) Scer\GAL4^da.G32, dm^Scer\UAS.cZa has small body \| larval stage phenotype, suppressible by dm^Scer\UAS.cZa (Khan et al., 2009, Khan et al., 2009) Scer\GAL4^dpp.blk1, dm^Scer\UAS.cZa has increased cell death \| cell non-autonomous phenotype, suppressible \| partially by hep^r75 (de la Cova et al., 2004) Scer\GAL4^dpp.blk1, dm^Scer\UAS.cZa has increased cell death \| cell non-autonomous phenotype, suppressible by Df(3L)H99 (de la Cova et al., 2004) Scer\GAL4^dpp.blk1, dm^Scer\UAS.cZa has increased cell death \| cell non-autonomous phenotype, suppressible by Df(3L)X14 (de la Cova et al., 2004) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has increased cell death phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Montero et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has size defective \| adult stage phenotype, suppressible \| partially by Hsap\RPL8^DN.Scer\UAS, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has size defective \| adult stage phenotype, suppressible \| partially by RpL8^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible \| adult stage phenotype, suppressible \| partially by Hsap\RPL8^DN.Scer\UAS, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible \| adult stage phenotype, suppressible \| partially by RpL8^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by ash2¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Asx^XF23 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by brm² (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(1)C246/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(2L)BSC5/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(2L)cl-h3/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(2L)E110/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(2L)net-PMF/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Df(3R)SR29/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Gcn5^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by lid¹⁰⁴²⁴ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by lid^k06801/lid[+] (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by mor¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Snr1⁰¹³¹⁹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, suppressible by Su(z)2^1.b7 (Secombe et al., 2007) Scer\GAL4^ptc-559.1, dm^Scer\UAS.cZa has increased cell size phenotype, suppressible \| partially by Scer\GAL4^ptc-559.1/vito^GD10890 (Marinho et al., 2011) Scer\GAL4^αTub84B.PL, dm^Scer\UAS.cZa has increased cell size \| somatic clone phenotype, suppressible by RpI135^k16513 (Grewal et al., 2005)
NOT suppressed by
Statement Reference Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has increased cell death phenotype, non-suppressible by p53^5A-1-4/p53^11-1B-1 (Montero et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by ash1^B1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by CycE^AR95 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by dap^2X10 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by Df(3L)H99 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by Df(3R)DG2/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by E2f^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by E(Pc)¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by kis¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by lid^17.1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by Max^{dsRNA.Scer\UAS.IR}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by osa² (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by Psc^1.d20 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by sktl^Δ20 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by T(1;3)sc^J4/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by Trl^s2325 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has visible phenotype, non-suppressible by trx^E2 (Secombe et al., 2007)
Enhancer of
Statement Reference dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is an enhancer of visible phenotype of Scer\GAL4^ey.PH, dac^Scer\UAS.cSa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^hh.PU is an enhancer of hyperplasia phenotype of ds^36D (Ziosi et al., 2010) dm^Scer\UAS.cZa/Scer\GAL4^hh.PU is an enhancer of hyperplasia phenotype of ex^e1 (Ziosi et al., 2010) dm^Scer\UAS.cZa/Scer\GAL4^hh.PU is an enhancer of hyperplasia phenotype of ft^G-rv (Ziosi et al., 2010) dm^Scer\UAS.cZa/Scer\GAL4^repo.PU is an enhancer of increased cell number \| third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.Scer\UAS.T:SV5\V5} (Reddy and Irvine, 2011)
Suppressor of
Statement Reference dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor \| partially of decreased cell number \| adult stage phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^en-e16E (Wang et al., 2008) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor \| partially of decreased cell size \| adult stage phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^en-e16E (Wang et al., 2008) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor \| partially of size defective phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^en-e16E (Wang et al., 2008) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor \| partially of visible phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^en-e16E (Wang et al., 2008) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor of decreased cell growth phenotype of Dcr-1^GD11429, Scer\GAL4^en-e16E (Herranz et al., 2010) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor of size defective phenotype of Dcr-1^GD11429, Scer\GAL4^en-e16E (Herranz et al., 2010) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Mef2^Scer\UAS.cBa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Poxn^Scer\UAS.cJa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^sca-537.4 is a suppressor \| partially of visible phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^sca-537.4 (Wang et al., 2008) dm^Scer\UAS.cZa/Scer\GAL4^Bx-MS1096 is a suppressor \| partially of visible phenotype of Scer\GAL4^Bx-MS1096, Tor^TED.Scer\UAS (Hennig and Neufeld, 2002) dm^Scer\UAS.cZa/Scer\GAL4^da.G32 is a suppressor \| partially of partially lethal - majority die phenotype of Scer\GAL4^da.G32, mir-308^Scer\UAS.cDa (Daneshvar et al., 2013) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Scer\GAL4^ey.PH, gsb^Scer\UAS.cJa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Scer\GAL4^ey.PH, prd^Scer\UAS.cJa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of visible phenotype of Scer\GAL4^ey.PH, sim^Scer\UAS.cXa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of size defective phenotype of L^fee (Wang and Huang, 2009) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of size defective phenotype of Tor^{WT.Scer\UAS.T:Zzzz\FLAG} (Wang and Huang, 2009) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of visible phenotype of Scer\GAL4^ey.PH, sv^Scer\UAS.cKa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of visible phenotype of Scer\GAL4^ey.PH, Tsc1^Scer\UAS.cTa, gig^Scer\UAS.cTa/gig^Scer\UAS.cTa (Tapon et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^mf9 is a suppressor of male sterile phenotype of Df(2L)Prl/prd⁴, prd^mf9 (Xue and Noll, 2002) dm^Scer\UAS.cZa/Scer\GAL4^αTub84B.PL is a suppressor of increased cell death \| somatic clone \| third instar larval stage phenotype of Dcr-1^Q1147X (Herranz et al., 2010) dm^Scer\UAS.cZa is a suppressor of small body \| larval stage phenotype of Scer\GAL4^da.G32, dm^Scer\UAS.cZa (Khan et al., 2009, Khan et al., 2009) Scer\GAL4^moody.PS/dm^Scer\UAS.cZa is a suppressor of decreased cell size phenotype of Scer\GAL4^moody.PS, dup^GD13203 (Unhavaithaya and Orr-Weaver, 2012) Scer\GAL4^moody.PS/dm^Scer\UAS.cZa is a suppressor of endomitotic cell cycle defective phenotype of Scer\GAL4^moody.PS, dup^GD13203 (Unhavaithaya and Orr-Weaver, 2012)
NOT Suppressor of
Statement Reference Scer\GAL4^prd.3.1/dm^Scer\UAS.cZa is a non-suppressor of male sterile phenotype of Df(2L)Prl/prd⁴ (Xue and Noll, 2002)
Other
Statement Reference Scer\GAL4^hh.PU, dm^Scer\UAS.cZa, ds^36D has increased cell size phenotype (Ziosi et al., 2010) Scer\GAL4^hh.PU, dm^Scer\UAS.cZa, ex^e1 has increased cell size phenotype (Ziosi et al., 2010) Scer\GAL4^hh.PU, dm^Scer\UAS.cZa, ft^G-rv has increased cell size phenotype (Ziosi et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has wing disc \| somatic clone phenotype, enhanceable by Hcf^{Scer\UAS.T:Zzzz\FLAG}/Scer\GAL4^GMR.PF (Furrer et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by ago⁴/ago[+] (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by lid^{C1296A.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by lid^{JmjC.mut.Scer\UAS.P\T}/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Secombe et al., 2007, Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by lid^{ΔARID.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by lid^{ΔPHD1.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by pUf68[+]/pUf68^EP3058/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Quinn et al., 2004) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/lid^{Scer\UAS.P\T.cSa}/Scer\GAL4^GMR.PF (Secombe et al., 2007, Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, enhanceable by Hcf^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Furrer et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, enhanceable by pUf68[+]/pUf68^EP3058/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Quinn et al., 2004) Scer\GAL4^repo.PU, dm^Scer\UAS.cZa has embryonic/larval brain \| third instar larval stage phenotype, enhanceable by yki^{Scer\UAS.cOa.T:SV5\V5}/Scer\GAL4^repo.PU (Reddy and Irvine, 2011) Scer\GAL4^repo.PU, dm^Scer\UAS.cZa has embryonic/larval glial cell \| third instar larval stage phenotype, enhanceable by yki^{Scer\UAS.cOa.T:SV5\V5}/Scer\GAL4^repo.PU (Reddy and Irvine, 2011) Scer\GAL4^repo.PU, dm^Scer\UAS.cZa has eye disc \| third instar larval stage phenotype, enhanceable by yki^{Scer\UAS.cOa.T:SV5\V5}/Scer\GAL4^repo.PU (Reddy and Irvine, 2011)
NOT Enhanced by
Statement Reference Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by CycE^AR95 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by dap^2X10 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by Df(3L)H99 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by E2f^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by lid^17.1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by lid^{ΔC5HC2.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by lid^{ΔJmjN.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-enhanceable by lid^{ΔPHD3.Scer\UAS.P\T}/Scer\GAL4^GMR.PF (Li et al., 2010)
Suppressed by
Statement Reference Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has mitotic cell cycle phenotype, suppressible by Dp^a1/Dp^a2 (Reis and Edgar, 2004) Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has salivary gland \| somatic clone phenotype, suppressible \| somatic clone by Hcf^{dsRNA.IR-2.Scer\UAS}, Scer\GAL4^Act5C.PP (Furrer et al., 2010) Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has salivary gland \| somatic clone phenotype, suppressible \| somatic clone by Hcf^{dsRNA.IR-3.Scer\UAS}, Scer\GAL4^Act5C.PP (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing disc phenotype, suppressible by Df(3L)G870/+ (Montero et al., 2008) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing disc phenotype, suppressible by Df(3L)H99 (Montero et al., 2008) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing phenotype, suppressible \| partially by Hcf^{dsRNA.IR-3.Scer\UAS}, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing phenotype, suppressible \| partially by Hcf^GD4353, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing phenotype, suppressible by Gcn5^GD11218, Scer\GAL4^ap-md544 (Furrer et al., 2010) Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing phenotype, suppressible by Scer\GAL4^ap-md544/ash2^GD1374 (Furrer et al., 2010) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye disc phenotype, suppressible \| partially by pUf68[+]/pUf68^EP3058/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Quinn et al., 2004) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye disc phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Montero et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible \| partially by Hsap\RPL8^DN.Scer\UAS, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible \| partially by Max^{dsRNA.Scer\UAS.IR}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008, Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible \| partially by RpL8^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Xu et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by ash2¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Asx^XF23 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by brm² (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(1)C246/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(2L)BSC5/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(2L)cl-h3/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(2L)E110/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(2L)net-PMF/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Df(3R)SR29/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Gcn5^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by lid¹⁰⁴²⁴ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by lid^k06801/lid[+] (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by mor¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Snr1⁰¹³¹⁹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, suppressible by Su(z)2^1.b7 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, suppressible \| partially by Mnt^{ΔSID.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has pigment cell phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008)
NOT suppressed by
Statement Reference Scer\GAL4^ap-md544, dm^Scer\UAS.cZa has wing disc phenotype, non-suppressible by p53^5A-1-4/p53^11-1B-1 (Montero et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by ash1^B1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by CycE^AR95 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by dap^2X10 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by Df(3L)H99 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by Df(3R)DG2/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by E2f^unspecified (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by E(Pc)¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by kis¹ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by lid^17.1 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by Mnt^{ΔZIP.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by osa² (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by Psc^1.d20 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by sktl^Δ20 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by T(1;3)sc^J4/+ (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by Trl^s2325 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has eye phenotype, non-suppressible by trx^E2 (Secombe et al., 2007) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, non-suppressible by Mnt¹ (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, non-suppressible by Mnt² (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has ommatidium phenotype, non-suppressible by Mnt^{ΔZIP.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa has pigment cell phenotype, non-suppressible by Max^{dsRNA.Scer\UAS.IR}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Steiger et al., 2008)
Enhancer of
Statement Reference dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is an enhancer of adult head phenotype of Scer\GAL4^ey.PH, dac^Scer\UAS.cSa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^repo.PU is an enhancer of embryonic/larval brain \| third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.Scer\UAS.T:SV5\V5} (Reddy and Irvine, 2011) dm^Scer\UAS.cZa/Scer\GAL4^repo.PU is an enhancer of embryonic/larval glial cell \| third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.Scer\UAS.T:SV5\V5} (Reddy and Irvine, 2011) dm^Scer\UAS.cZa/Scer\GAL4^repo.PU is an enhancer of eye disc \| third instar larval stage phenotype of Scer\GAL4^repo.PU, yki^{S168A.Scer\UAS.T:SV5\V5} (Reddy and Irvine, 2011)
Suppressor of
Statement Reference dm^Scer\UAS.cZa, Scer\GAL4^Act5C.PP is a suppressor \| partially \| somatic clone of mitotic cell cycle \| somatic clone phenotype of Ras85D^N17.Scer\UAS, Scer\GAL4^Act5C.PP (Prober and Edgar, 2000) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor \| partially of wing \| posterior phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^en-e16E (Wang et al., 2008) dm^Scer\UAS.cZa, Scer\GAL4^en-e16E is a suppressor of wing blade phenotype of Dcr-1^GD11429, Scer\GAL4^en-e16E (Herranz et al., 2010) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Mef2^Scer\UAS.cBa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Poxm^Scer\UAS.cJa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Poxn^Scer\UAS.cJa, Scer\GAL4^ey.PH (Jiao et al., 2001) dm^Scer\UAS.cZa, Scer\GAL4^ptc-559.1 is a suppressor \| partially of embryonic/larval salivary gland phenotype of Pi3K21B^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ptc-559.1 (Pierce et al., 2004) dm^Scer\UAS.cZa, Scer\GAL4^sca-537.4 is a suppressor \| partially of scutellar bristle phenotype of Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^sca-537.4 (Wang et al., 2008) dm^Scer\UAS.cZa/Scer\GAL4^Bx-MS1096 is a suppressor \| partially of wing phenotype of Scer\GAL4^Bx-MS1096, Tor^TED.Scer\UAS (Hennig and Neufeld, 2002) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Scer\GAL4^ey.PH, gsb^Scer\UAS.cJa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Scer\GAL4^ey.PH, prd^Scer\UAS.cJa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor \| partially of adult head phenotype of Scer\GAL4^ey.PH, sim^Scer\UAS.cXa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of adult head phenotype of Scer\GAL4^ey.PH, sv^Scer\UAS.cKa (Jiao et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of eye phenotype of L^fee (Wang and Huang, 2009) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of eye phenotype of Scer\GAL4^ey.PH, Tsc1^Scer\UAS.cTa, gig^Scer\UAS.cTa/gig^Scer\UAS.cTa (Tapon et al., 2001) dm^Scer\UAS.cZa/Scer\GAL4^ey.PH is a suppressor of eye phenotype of Tor^{WT.Scer\UAS.T:Zzzz\FLAG} (Wang and Huang, 2009) dm^Scer\UAS.cZa/Scer\GAL4^mf9 is a suppressor of male accessory gland phenotype of Df(2L)Prl/prd⁴, prd^mf9 (Xue and Noll, 2002) dm^Scer\UAS.cZa/Scer\GAL4^αTub84B.PL is a suppressor \| partially of wing disc \| somatic clone \| third instar larval stage phenotype of Dcr-1^Q1147X (Herranz et al., 2010) Scer\GAL4^moody.PS/dm^Scer\UAS.cZa is a suppressor of subperineurial glial cell phenotype of Scer\GAL4^moody.PS, dup^GD13203 (Unhavaithaya and Orr-Weaver, 2012)
NOT Suppressor of
Statement Reference dm^Scer\UAS.cZa, Scer\GAL4^tub.PU, th^{V85M.Scer\UAS} is a non-suppressor of wing disc \| somatic clone \| cell autonomous phenotype of yki^B5 (Neto-Silva et al., 2010) Scer\GAL4^prd.3.1/dm^Scer\UAS.cZa is a non-suppressor of male accessory gland phenotype of Df(2L)Prl/prd⁴ (Xue and Noll, 2002)
Other
Statement Reference BacA\p35^Scer\UAS.cHa, Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has wing disc \| somatic clone \| third instar larval stage phenotype (Mitchell et al., 2010) Df(3L)H99, Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has wing disc \| anterior phenotype (de la Cova et al., 2004) Df(3L)X14, Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa has wing disc \| anterior phenotype (de la Cova et al., 2004) Scer\GAL4^Act5C.PP, dm^Scer\UAS.cZa, stg^Scer\UAS.cNa has cell cycle phenotype (Johnston et al., 1999, Johnston et al., 1999) Scer\GAL4^ptc-559.1, dm^Scer\UAS.cZa, vito^GD10890 has nucleolus phenotype (Marinho et al., 2011) Scer\GAL4^tub.PU, ban^EP3622, dm^Scer\UAS.cZa, yki^B5 has wing disc \| somatic clone \| cell autonomous phenotype (Neto-Silva et al., 2010) Scer\GAL4^tub.PU, dm^Scer\UAS.cZa, yki^B5 has wing disc \| somatic clone \| cell autonomous phenotype (Neto-Silva et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of both dm[Scer\UAS.cZa] and mir-308[Scer\UAS.cDa] under the control of Scer\GAL4[da.G32] results in an increased proportion of the animals surviving to 96 hours after egg deposition compared to expression of either construct alone. (Daneshvar et al., 2013) Co-expression of dm[Scer\UAS.cZa] in subperineurial glia, with dup[GD13203], both under the control of Scer\GAL4[moody.PS], can restore normal cell size, polyploidy and accelerate the G1/S progression to wild-type levels. (Unhavaithaya and Orr-Weaver, 2012) Co-expression of vito[GD10890] reduces the size of Scer\GAL4[Act5C.PI]-indcued dm[Scer\UAS.cZa] clones to control levels. This is the consequence of partial reversion of the dm[Scer\UAS.cZa]-induced cell size increase together with a decrease in the number of cells per clone. Co-expression of vito[GD10890] considerably attenuates the increased cell size seen in Scer\GAL4[ptc-559.1], dm[Scer\UAS.cZa] salivary glands. This is a result of significant reductions in cytoplasmic and nuclear volumes. The nucleoli display a segregated organization, with a peripheral granular region surrounding an internal fibrillar area. (Marinho et al., 2011) Co-expression of dm[Scer\UAS.cZa] and yki[S168A.Scer\UAS.T:SV5\V5] under the control of Scer\GAL4[repo.PU] results in substantial increase in the number of glial cells in the larval eye disc and brain, greater than when either is expressed alone. Ethyl deoxyuridine (EdU) staining shows that there is increased glial cell proliferation in the cortex compared to controls, whereas this is not seen in the individual mutants. (Reddy and Irvine, 2011) The increased ommatidial size caused by expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] is enhanced by co-expression of Hcf[Scer\UAS.T:Zzzz\FLAG]. Co-expression of Hcf[Scer\UAS.T:Zzzz\FLAG] enhances the overgrowth seen in wing disc clones expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP]. The wing defects caused by expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] are partially suppressed by co-expression of either Hcf[GD4353] or Hcf[dsRNA.IR-3.Scer\UAS]. Co-expression of either Hcf[dsRNA.IR-2.Scer\UAS] or Hcf[dsRNA.IR-3.Scer\UAS] strongly suppresses the excessive endoreplication seen in clones in the larval salivary glands expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP]. The wing defects caused by expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] are suppressed by co-expression of either ash2[GD1374] or Pcaf[GD11218]. (Furrer et al., 2010) The tissue and cell size defects caused by Scer\GAL4[en-e16E]>Dcr-1[GD11429] in adult wings are largely suppressed when dm[Scer\UAS.cZa] is co-expressed. Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[αTub84B.PL] in Dcr-1[Q1147X] mutant somatic clones completely suppresses cell loss, but clone size is not completely restored. (Herranz et al., 2010) Expression of dm[Scer\UAS.cZa] in yki[B5] wing disc clones (under the control of Scer\GAL4[tub.PU]) fails to rescue the growth defect of yki[B5] mutant clones. However, despite the small size of the clones, cell and nucleolar size are increased when dm[Scer\UAS.cZa] is expressed in yki[B5] wing discs. Co-expression of dm[Scer\UAS.cZa] and th[V85M.Scer\UAS] in wing disc clones (under the control of Scer\GAL4[tub.PU]) in yki[B5] mutant animals fails to rescue the growth defect of yki[B5] mutant clones, and growth rates are similar to when th[V85M.Scer\UAS] is expressed alone in yki[B5] mutant discs. Co-expression of dm[Scer\UAS.cZa] and ban[EP3622] in wing disc clones (under the control of Scer\GAL4[tub.PU]) in yki[B5] mutant animals fails to rescue the growth defect of yki[B5] mutant clones, and growth rates are similar to when th[V85M.Scer\UAS] is expressed alone in yki[B5] mutant discs. However, despite the small size of the clones, cell and nucleolar size are increased when dm[Scer\UAS.cZa] and ban[EP3622] are expressed in yki[B5] wing discs. (Neto-Silva et al., 2010) dm[Scer\UAS.cZa] overexpression clones (under the control of Scer\GAL4[hh.PU]) found in the posterior of the wing disc strongly enhance the proliferative activity of ft[G-rv], ds[36D] and ex[e1] mutant cells. In addition these cells are larger in dm[Scer\UAS.cZa] clones than in a wild-type background. (Ziosi et al., 2010) Larvae co-expressing both dm[Scer\UAS.cZa] and Su(z)2[d01221] under the control of Scer\GAL4[da.G32] hatch and grow normally. (Khan et al., 2009) Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[ey.PH] in a L[fee] background significantly restores eye size. Co-expression of dm[Scer\UAS.cZa] suppresses the reduction in eye size caused by expression of Tor[WT.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[ey.PH]. (Wang and Huang, 2009) The increased apoptosis that is seen in wing discs expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] is not reduced by p53[5A-1-4]/p53[11-1B-1]. The increased apoptosis that is seen in wing discs expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] is suppressed by Df(3L)G870/+. The increased apoptosis that is seen in wing discs expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[ap-md544] is reduced by Df(3L)H99. (Montero et al., 2008) Co-expression of Max[dsRNA.Scer\UAS.IR] does not suppress the eye apoptosis phenotype caused by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF]. The increase in ommatidial size caused by expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] is suppressed by co-expression of Max[dsRNA.Scer\UAS.IR]. (Steiger et al., 2008) Co-expression of Max[dsRNA.Scer\UAS.IR] does not suppress the eye apoptosis phenotype caused by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF]. The increase in ommatidial size caused by expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] is suppressed by co-expression of Max[dsRNA.Scer\UAS.IR]. Co-expression of Mnt[ΔSID.Scer\UAS] suppresses the increase in ommatidial size caused by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF], but does not suppress apoptosis, resulting in a small and rough eye phenotype. Co-expression of Mnt[ΔZIP.Scer\UAS] has no affect on the eye phenotypes caused by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF]. The eye phenotypes (apoptosis and increased ommatidial size) caused by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] are not qualitatively altered by either Mnt[1]/Y or Mnt[2]/Y. (Steiger et al., 2008) Expression of RpL8[dsRNA.Scer\UAS] partially suppresses the increase in eye size seen when dm[Scer\UAS.cZa] is expressed under the control of Scer\GAL4[GMR.PF]. (Xu et al., 2008) Co-expression of lid^{Scer\UAS.P\T.cSa} dramatically enhances the rough eye phenotype caused by expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF. Co-expression of lid^{JmjC.mut.Scer\UAS.P\T} enhances the rough eye phenotype caused by expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF. (Secombe et al., 2007) When dm^Scer\UAS.cZa is expressed clonally using the MARCM GAL repressor/activator system in wing disc cells that are RpI135^k16513 mutant, the cell size effects of dm^Scer\UAS.cZa overexpression are significantly diminished. Cell cycle effects of dm^Scer\UAS.cZa overexpression are partially reversed in RpI135^k16513 homozygous mutant cells. (Grewal et al., 2005) The amount of cell death seen in cells not expressing dm^Scer\UAS.cZa (in wing disc somatic clones driven by Scer\GAL4^Act5C.PP) is reduced by about 15%. The presence of Df(3L)H99/+ or Df(3L)X14/+ in wing discs with dm^Scer\UAS.cZa expressing clones (driven by Scer\GAL4^dpp.blk1) does not cause a growth disadvantage in cells neighbouring the clones. Neutral clones are similar in size whether near or far from the dm^Scer\UAS.cZa expressing cells. The anterior compartment in these discs is also significantly larger than normal. The presence of hep^r75/+ in wing discs with dm^Scer\UAS.cZa expressing clones (driven by Scer\GAL4^dpp.blk1) only reduces the cell death induced by cell competition by 30%. Wing discs are normal in size. (de la Cova et al., 2004) The increased eye size and enlarged ommatidia of dm^Scer\UAS.cZa; Scer\GAL4^GMR.PF flies is enhanced by pUf68^EP3058/+. The resulting ommatidia are disorganised. The reduced thickness of bands of s-phase and mitotic cells posterior to the furrow in dm^Scer\UAS.cZa; Scer\GAL4^GMR.PF eye discs is largely suppressed by pUf68^EP3058/+. (Quinn et al., 2004) Cells expressing dm^Scer\UAS.cZa driven by Scer\GAL4^Act5C.PP in a Dp^a1/Dp^a2 background, the compensatory elongation of the G2 phase, is not as pronounced seen in dm^Scer\UAS.cZa expressing cells. (Reis and Edgar, 2004) The compensatory elongation of G2 phase seen in cells expressing dm^Scer\UAS.cZa driven by Scer\GAL4^Act5C.PP is not as pronounced in a Dp^a1/Dp^a2 background. (Reis and Edgar, 2004) Expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^Act5C.PI in clones in the eye disc which are homozygous for scrib¹ increases the amount of mutant tissue compared to scrib¹ single mutant clones, but the double mutant clones do not show metastatic behaviour. (Pagliarini and Xu, 2003) The reduced wing phenotype caused by expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is partially suppressed by dm^Scer\UAS.cZa. (Hennig and Neufeld, 2002) When dm^Scer\UAS.cZa (driven by Scer\GAL4^mf9) is added to Df(2L)Prl/prd⁴, (partially rescued by a weakly expressing prd^mf9 line), the accessory gland phenotype is reduced, and male fertility is restored. When dm^Scer\UAS.cZa (driven by Scer\GAL4^prd.3.1) is added to Df(2L)Prl/prd⁴, however, no rescue is seen. (Xue and Noll, 2002) Expression of both Tsc1^Scer\UAS.cTa and gig^Scer\UAS.cTa in the eye under the control of Scer\GAL4^ey.PH results in a much smaller eye than normal. Coexpression of dm^Scer\UAS.cZa suppresses the phenotype. (Tapon et al., 2001) When dm^Scer\UAS.cZa and stg^Scer\UAS.cNa are co-expressed via Scer\GAL4^Act5C.PP in clones in the wing disc the cells show a 76% reduction in G2 cells (compared to dm^Scer\UAS.cZa alone). There is an increase of cells in G1 from 5% (dm^Scer\UAS.cZa alone) to 20%. Doubling time of cells was shortened from 12.9 to 10.6 hours. G1/S progression is promoted and the S and G2 phases of the cell cycle elongated. When dm^Scer\UAS.cZa and stg^Scer\UAS.cNa are co-expressed via Scer\GAL4^Act5C.PP cells are smaller than for dm^Scer\UAS.cZa, dm^Scer\UAS.cZa alone, though the area of the dm^Scer\UAS.cZa, stg^Scer\UAS.cNa, Scer\GAL4^Act5C.PP clones is larger than that of the dm^Scer\UAS.cZa, dm^Scer\UAS.cZa clones, because of reduced doubling time couple with reduced time between cell divisions. (Johnston et al., 1999)
Xenogenetic Interactions
Statement Reference Expression of BacA\p35[Scer\UAS.cHa] in wing disc clones expressing dm[Scer\UAS.cZa] under the control of Scer\GAL4[Act5C.PP] results in large rounded cells 72 hours after clone induction. These enlarged cells are removed from the apical surface of the wind disc epithelium and extruded basally. Some mutant cells undergo apoptosis. (Mitchell et al., 2010) The increased apoptosis that is seen in larval eye discs expressing three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] is suppressed by co-expression of BacA\p35[Scer\UAS.cHa]. Co-expression of BacA\p35[Scer\UAS.cHa] and three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF] results in eyes and ommatidia that are significantly larger than eyes expressing either dm[Scer\UAS.cZa] or BacA\p35[Scer\UAS.cHa] alone. (Montero et al., 2008) Co-expression of BacA\p35[Scer\UAS.cHa] suppresses the reduction in pigment cells and disturbance of the internal architecture of the adult eye seen in animals by expression of three copies of dm[Scer\UAS.cZa] under the control of Scer\GAL4[GMR.PF]. (Steiger et al., 2008) Expression of dm[Scer\UAS.cZa] partially suppresses the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[en-e16E] or Scer\GAL4[sca-537.4] respectively. (Wang et al., 2008) Expression of Hsap\RPL8[DN.Scer\UAS] partially suppresses the increase in eye size seen when dm[Scer\UAS.cZa] is expressed under the control of Scer\GAL4[GMR.PF]. (Xu et al., 2008)
Complementation & Rescue Data
Rescues	dm^Scer\UAS.cZa/Scer\GAL4^C-765 rescues dm^P0 (Johnston et al., 1999) dm^Scer\UAS.cZa/Scer\GAL4^C-765 rescues dm^P1 (Johnston et al., 1999) dm^Scer\UAS.cZa/Scer\GAL4^sca-109-68 rescues dm^P0 (Johnston et al., 1999) dm^Scer\UAS.cZa/Scer\GAL4^sca-109-68 rescues dm^P1 (Johnston et al., 1999) Scer\GAL4^en-e16E/dm^Scer\UAS.cZa rescues dm^P0 (Johnston et al., 1999)
Fails to rescue	Scer\GAL4^dm-PG45/dm^Scer\UAS.cZa fails to rescue dm^PG45 (Benassayag et al., 2005)
Comments	Expression of dm[Scer\UAS.cZa] under the control of Scer\GAL4[dm-PG45] fails to rescue the lethality of dm[PG45] males (at either 18, 22 or 26[o]C). (Benassayag et al., 2005) When expression is driven by Scer\GAL4^sca-109-68 or Scer\GAL4^C-765, dm^Scer\UAS.cZa rescues the bristle area defect, cell area reduction, wing width and length reductions of dm^P0 and the bristle area defect of dm^P1 (rescue of wing phenotypes for dm^P1 was not determined). When expression is driven by Scer\GAL4^en-e16E the growth disadvantage of dm^P0 clones in the wing disc is rescued. (Johnston et al., 1999)
Stocks ( 2 )
Bloomington	9674 w¹¹¹⁸; P{UAS-dm.Z}132 9675 P{hsFLP}22, y¹ w^*; P{UAS-dm.Z}42
Notes on Origin
Discoverer

External Crossreferences & Linkouts
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Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dm^Scer\UAS.cZa dm^UAS.cZa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Zaffran (Zaffran et al., 1998)
Secondary FlyBase IDs

References ( 57 )

Generate a list of	All references relating to this allele ( 57 )

List References by type	Research paper ( 55 ) Supplementary material ( 2 )
Recent research papers ( 6 )
	Daneshvar et al., 2013, Biol. Open 2(1): 1--9 MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. [FBrf0220584] Unhavaithaya and Orr-Weaver, 2012, Genes Dev. 26(1): 31--36 Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. [FBrf0217041] Becam et al., 2011, Development 138(17): 3781--3789 Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. [FBrf0214603] Kawamori and Yamaguchi, 2011, Cell Struct. Funct. 36(1): 103--119 DREF is Critical for Drosophila Bristle Development by Regulating Endoreplication in Shaft Cells. [FBrf0213809] Marinho et al., 2011, Development 138(2): 349--357 The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. [FBrf0212565] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Show all research papers ...

Allele Dmel\dmScer\UAS.cZa

Allele Dmel\dm^Scer\UAS.cZa