Allele Dmel\comm^ΔC.Scer\UAS

General Information
Symbol	Dmel\comm^ΔC.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0093115
Feature type	allele	Associated gene	Dmel\comm

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Wolf et al., 1998, Myat et al., 2002) in vitro construct - regulatory fusion (Wolf et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: comm coding region lacks intracellular region. (Myat et al., 2002) Construct: Scer\UAS regulatory sequences drive expression of a truncated form of comm which lacks the entire cytoplasmic domain after amino acid 185. (Wolf et al., 1998)
Carried in construct	P{UAS-comm.ΔC} (Godenschwege et al., 2002, Myat et al., 2002, Wolf et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	abdominal segmental nerve, with Scer\GAL4^how-24B (Wolf et al., 1998) intersegmental nerve, with Scer\GAL4^how-24B (Wolf et al., 1998)
Detailed Description
	Statement Reference When driven by Scer\GAL4^elav-C155 the anterior and posterior commissures of the CNS appear normal. (Myat et al., 2002) The motoneuron growth cones of embryos expressing comm^ΔC.Scer\UAS under the control of Scer\GAL4^how-24B fail to initiate synaptogenesis and often stall just short of the target muscles. These phenotypes are seen in the five motoneuron nerve groups (the ISN, SNa, SNb, SNc and SNd). (Wolf et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.Scer\UAS is a suppressor of neuroanatomy defective phenotype of Scer\GAL4^{shakB.lethal.4.1}, lea^Scer\UAS.cSa (Godenschwege et al., 2002) Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.Scer\UAS is a suppressor of neurophysiology defective phenotype of Scer\GAL4^{shakB.lethal.4.1}, lea^Scer\UAS.cSa (Godenschwege et al., 2002)
NOT Suppressor of
Statement Reference Scer\GAL4^A307/comm^ΔC.Scer\UAS is a non-suppressor of neuroanatomy defective phenotype of Scer\GAL4^A307, robo^Scer\UAS.cKa (Godenschwege et al., 2002) Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.Scer\UAS is a non-suppressor of neuroanatomy defective phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo^Scer\UAS.cKa (Godenschwege et al., 2002)
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.Scer\UAS is a suppressor of giant fiber neuron phenotype of Scer\GAL4^{shakB.lethal.4.1}, lea^Scer\UAS.cSa (Godenschwege et al., 2002)
NOT Suppressor of
Statement Reference Scer\GAL4^{shakB.lethal.4.1}/comm^ΔC.Scer\UAS is a non-suppressor of giant fibers & dendrite phenotype of Scer\GAL4^{shakB.lethal.4.1}, robo^Scer\UAS.cKa (Godenschwege et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Coexpression of comm^ΔC.Scer\UAS, under the control of Scer\GAL4^A307, with robo^Scer\UAS.cKa or lea^Scer\UAS.cSa has no effect on the robo or lea-induced giant fiber axon deflection. Coexpression of comm^ΔC.Scer\UAS with robo^Scer\UAS.cKa, under the control of Scer\GAL4^{shakB.lethal.4.1} has no effect on the ability of robo to disrupt the dendritic guidance of the tergotrochanteral motor neurons. (Godenschwege et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	comm^ΔC.Scer\UAS comm^ΔC.UAS comm^ΔC (Myat et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Godenschwege et al., 2002, J. Neurosci. 22(8): 3117--3129 Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity. [FBrf0147116] Myat et al., 2002, Neuron 35(3): 447--459 Drosophila nedd4, a ubiquitin ligase, is recruited by commissureless to control cell surface levels of the roundabout receptor. [FBrf0151451] Wolf et al., 1998, Development 125(19): 3853--3863 Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis. [FBrf0104897]

Allele Dmel\commΔC.Scer\UAS

Allele Dmel\comm^ΔC.Scer\UAS