Allele Dmel\caup^{Scer\UAS.cdCa}

General Information
Symbol	Dmel\caup^{Scer\UAS.cdCa}	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of del Corral	FlyBase ID	FBal0093133
Feature type	allele	Associated gene	Dmel\caup

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Grillenzoni et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive caup expression. (Grillenzoni et al., 1998)
Carried in construct	P{UAS-caup.dC} (Lunde et al., 2003, Cavodeassi et al., 2000, Cavodeassi et al., 1999, Diez del Corral et al., 1999, Dominguez and de Celis, 1998, Grillenzoni et al., 1998, Tomlinson, 2003, Wernet et al., 2003, Carrasco-Rando et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective, with Scer\GAL4^Act5C.PI (Cavodeassi et al., 1999) visible, with Scer\GAL4^ey.PH (Dominguez and de Celis, 1998)
Phenotype Manifest In
	dorsal margin photoreceptor \| ectopic, with Scer\GAL4^GMR.PF (Tomlinson, 2003) eye, with Scer\GAL4^Act5C.PI (Cavodeassi et al., 1999) eye, with Scer\GAL4^ey.PH (Dominguez and de Celis, 1998) eye \| ectopic, with Scer\GAL4^Act5C.PI (Cavodeassi et al., 1999) ommatidium, with Scer\GAL4^Act5C.PI (Cavodeassi et al., 1999) scutum & microchaeta \| medial, with Scer\GAL4^sca-537.4 (Grillenzoni et al., 1998) vertical bristle, with Scer\GAL4^ey.PH (Dominguez and de Celis, 1998)
Detailed Description
	Statement Reference Misexpression of caup^{Scer\UAS.cdCa}, driven by Scer\GAL4^GMR.PF, in the ventral half of the eye allows the ectopic formation of dorsal rim ommatidia at the ventral extreme. (Tomlinson, 2003) Clones in the ventral region of the eye expressing caup^{Scer\UAS.cdCa} under the control of Scer\GAL4^Act5C.PI reorganise dorsoventral polarity and promoter formation of ectopic eye fields at a low frequency. Dorsally situated clones expressing caup^{Scer\UAS.cdCa} under the control of Scer\GAL4^Act5C.PI induce ectopic eyes at a low frequency. (Cavodeassi et al., 1999) When expression is driven by Scer\GAL4^ey.PH, the eye is very much reduced, and shows duplication of dorsal bristles. (Dominguez and de Celis, 1998) The medial macrochaetae of the notum have wild-type contralateral axonal branches in flies expressing caup^{Scer\UAS.cdCa} under the control of Scer\GAL4^sca-537.4. In contrast, the medial microchaetae of the notum lack all contralateral axonal branches in approximately 80% of these flies. (Grillenzoni et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^ey.PH, caup^{Scer\UAS.cdCa} has eye phenotype, suppressible \| partially by N^{int.SH.Scer\UAS}, Scer\GAL4^ey.PH (Dominguez and de Celis, 1998)
Other
Statement Reference N^{int.SH.Scer\UAS}, Scer\GAL4^ey.PH, caup^{Scer\UAS.cdCa} has ommatidium phenotype (Dominguez and de Celis, 1998, Dominguez and de Celis, 1998)
Additional Comments
Genetic Interactions
Statement Reference The eye-size effect in flies expressing caup^{Scer\UAS.cdCa} under the control of Scer\GAL4^ey.PH can be partially rescued by simultaneous expression of N^{int.SH.Scer\UAS}, though ommatidia are abnormally arranged. (Dominguez and de Celis, 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	R. del Corral J.L. Skarmeta J. Modolell

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	caup^{Scer\UAS.cdCa} caup^UAS.cdCa
Name Synonym	Saccharomyces cerevisiae UAS construct a of del Corral (Grillenzoni et al., 1998)
Secondary FlyBase IDs

References ( 9 )
Research paper	Carrasco-Rando et al., 2011, PLoS Genet. 7(7): e1002186 Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate. [FBrf0214635] Lunde et al., 2003, Development 130(2): 235--248 Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. [FBrf0155705] Tomlinson, 2003, Dev. Cell 5(5): 799--809 Patterning the peripheral retina of the fly: decoding a gradient. [FBrf0167480] Wernet et al., 2003, Cell 115(3): 267--279 Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. [FBrf0167367] Cavodeassi et al., 2000, Development 127(9): 1921--1929 The Iroquois homeobox genes function as dorsal selectors in the Drosophila head. [FBrf0127036] Cavodeassi et al., 1999, Development 126(22): 4933--4942 Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins. [FBrf0111829] Diez del Corral et al., 1999, Genes Dev. 13(13): 1754--1761 The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila. [FBrf0108698] Dominguez and de Celis, 1998, Nature 396(6708): 276--278 A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. [FBrf0105420] Grillenzoni et al., 1998, Development 125(18): 3563--3569 The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections. [FBrf0104751]

Allele Dmel\caupScer\UAS.cdCa

Allele Dmel\caup^{Scer\UAS.cdCa}