FlyBase Allele Report: Dmel\Rho1[V14.sev]

General Information

Symbol

Dmel\Rho1^V14.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0093216

Feature type

allele

Associated gene

Dmel\Rho1

Associated Insertion(s)

Carried in Construct

P{sE-Rho1.V14}

Also Known As

sev-RhoA^V14

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Boutros et al., 1998)

Progenitor genotype

Carried in construct

P{sE-Rho1.V14}

Cytology

Description

Allele components

Component

Use(s)

Encoded product / tool

Rho1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Fanto et al., 2000)

abnormal planar polarity | somatic clone

(Strutt et al., 2002)

visible

(Pazman et al., 2000)

Phenotype Manifest In

eye

(Fanto et al., 2000, Pazman et al., 2000)

eye photoreceptor cell | somatic clone

(Strutt et al., 2002)

ommatidium

(Strutt et al., 2002)

ommatidium | somatic clone

(Strutt et al., 2002)

photoreceptor neuron

(Fanto et al., 2000)

Detailed Description

Statement

Reference

Ommatidial rotation is severely disrupted in Rho1^V14.sev mutants. 40.8% of ommatidia in mutant somatic clones in the eye are normal. 3.3% have rotated ommatidia, none have chirality defects, none are achiral (55.9% unscorable).

(Strutt et al., 2002)

Low levels of expression of Rho1^V14.sev leads to photoreceptor loss but no significant polarity defects. At higher levels polarity defects become apparent. Misorientated clusters are present from the earliest detectable stage and are thus primary defects.

(Fanto et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rho1^V14.sev has visible phenotype, enhanceable by rin[+]/rin^unspecified

(Pazman et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rho1^V14.sev has eye phenotype, enhanceable by rin[+]/rin^unspecified

(Pazman et al., 2000)

NOT Enhanced by

Statement

Reference

Rho1^V14.sev has phenotype, non-enhanceable by ex^e1

(Blaumueller and Mlodzik, 2000)

NOT suppressed by

Statement

Reference

Rho1^V14.sev has phenotype, non-suppressible by ex^e1

(Blaumueller and Mlodzik, 2000)

NOT Enhancer of

Statement

Reference

Rho1^V14.sev is a non-enhancer of phenotype of ex^e1

(Blaumueller and Mlodzik, 2000)

Suppressor of

Statement

Reference

Rho1^V14.sev is a suppressor of phenotype of dsh¹

(Boutros et al., 1998)

NOT Suppressor of

Statement

Reference

Rho1^V14.sev is a non-suppressor of phenotype of ex^e1

(Blaumueller and Mlodzik, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Partially rescues the ommatidial polarity phenotype of dsh¹ mutants.

(Boutros et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

U. Weber

(Boutros et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rho1^V14.hs.sev

Rho1^V14.sev

Rho^V14

(Kockel et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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