FlyBase Allele Report: Dmel\twe[EP613]

General Information

Symbol

Dmel\twe^EP613

Species

D. melanogaster

Name

FlyBase ID

FBal0093757

Feature type

allele

Associated gene

Dmel\twe

Associated Insertion(s)

P{EP}twe^EP613

Carried in Construct

Also Known As

EP(2)0613

Genomic Maps

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Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bidet et al., 2003, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Roote, 1998.11.16)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable element insertion site

2L:16,261,770..16,261,770 [-]

(Bidet et al., 2003, Shulman and Feany, 2003, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Roote, 1998.11.16)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

P{EP} insertion 9bp upstream of the twe translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of twe.

(Bidet et al., 2003)

The orientation of the P{EP} element is the same as the direction of twe transcription.

(Shulman and Feany, 2003)

P{EP} insertion at -290bp relative to the start of the transcription unit.

(Abdelilah-Seyfried et al., 2000)

Insertion components

P{EP}twe^EP613

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

misexpression element

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

female fertile, with Scer\GAL4^- :

(Ashburner et al., 1999, Roote, 1998.11.16)

male sterile, with Scer\GAL4^- :

(Roote, 1998.11.16)

male sterile | recessive, with Scer\GAL4^- :

(Ashburner et al., 1999, Ashburner et al., 1999)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of twe^EP613 under the control of Scer\GAL4^sca-537.4 results in potential shaft-to-socket transformations. Rarely, sensory organs with 4 sockets and no shaft are seen. Additional scutellar and dorsocentral macrochaetae are seen. Sensory organs with two sockets and two shafts, one socket and two shafts, no socket and one shaft and short and thickened shaft morphology are seen.

(Abdelilah-Seyfried et al., 2000)

Male sterile but female fertile when transheterozygous with twe¹.

(Ashburner et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, twe^EP613 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, twe^EP613 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, twe^EP613 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, twe^EP613 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT Enhancer of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

twe^EP613/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

twe^EP613/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

twe^EP613, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

twe^EP613/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by twe^EP613.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{EP} element reverts the modifying effect of twe^EP613 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP(2)0613

(Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

twe^EP613

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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