Allele Dmel\sca^73-1

General Information
Symbol	Dmel\sca^73-1	Species	D. melanogaster
Name		FlyBase ID	FBal0093789
Feature type	allele	Associated gene	Dmel\sca

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Mlodzik, 2000.1.26)
Mutagen	P-element activity (Lee et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References complex substitution 2R:8,667,991..8,669,047 evidence=experimental comment=Insertion of P{GawB}sca^73-1 together with deletion of exon 1 and adjacent sequences. (Lee et al., 1998)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of a P{GawB} element after -59bp (relative to the transcription start site), together with deletion of the first exon. The 3' end of the P{GawB} element is located distal (relative to the direction of sca transcription) to the 5' end, and both 5' and 3' ends are mutated and rearranged. (Lee et al., 1998)
Caused by insertion	P{GawB}sca^73-1 (Lee et al., 1998, Chou and Chien, 2002, Mlodzik, 2000.1.26)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| recessive (Lee et al., 1998)
Phenotype Manifest In
	adult thorax & macrochaeta (Lee et al., 1998)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference sca^73-1 has visible \| recessive phenotype, suppressible \| partially by Scer\GAL4^sca-73-1/sca::Hsap\FGA^Scer\UAS.cLa (Lee et al., 1998) sca^73-1 has visible \| recessive phenotype, suppressible \| partially by Scer\GAL4^sca-73-1/sca::Hsap\FGB^{C286A.Scer\UAS} (Lee et al., 1998)
Phenotype Manifest In
Suppressed by
Statement Reference sca^73-1 has adult thorax & macrochaeta phenotype, suppressible \| partially by Scer\GAL4^sca-73-1/sca::Hsap\FGA^Scer\UAS.cLa (Lee et al., 1998) sca^73-1 has adult thorax & macrochaeta phenotype, suppressible \| partially by Scer\GAL4^sca-73-1/sca::Hsap\FGB^{C286A.Scer\UAS} (Lee et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference sca::Hsap\FGA^Scer\UAS.cLa or sca::Hsap\FGB^{C286A.Scer\UAS} expressed under the control of Scer\GAL4^sca-73-1 partially rescues the sca^BP2/sca^73-1 extra thoracic bristle phenotype. sca::Hsap\FGG^Scer\UAS.cLa expressed under the control of Scer\GAL4^sca-73-1 does not rescue the sca^BP2/sca^73-1 extra thoracic bristle phenotype and may increase the number of ectopic bristles compared to the number seen in sca^BP2/sca^73-1 flies. (Lee et al., 1998)
Complementation & Rescue Data
Fails to complement	sca^unspecified (Lee et al., 1998)
Partially rescued by	sca^73-1/sca^BP2 is partially rescued by Scer\GAL4^sca-73-1/sca^{D654N.Scer\UAS} (Lee et al., 1998) sca^73-1/sca^BP2 is partially rescued by Scer\GAL4^sca-73-1/sca^{MSKF.Scer\UAS} (Lee et al., 1998) sca^73-1/sca^BP2 is partially rescued by Scer\GAL4^sca-73-1/sca^Scer\UAS.cEa (Lee et al., 1998) sca^73-1/sca^BP2 is partially rescued by Scer\GAL4^sca-73-1/sca^{Δ513-774.Scer\UAS} (Lee et al., 1998)
Not rescued by	sca^73-1/sca^BP2 is not rescued by Scer\GAL4^sca-73-1/sca^{Δ41-463.Scer\UAS} (Lee et al., 1998) sca^73-1/sca^BP2 is not rescued by Scer\GAL4^sca-73-1/sca^{Δ41-514.Scer\UAS} (Lee et al., 1998)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	sca^73-1 sca^73/1 (Chou and Chien, 2002)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Chou and Chien, 2002, Dev. Cell 3(6): 839--850 Scabrous controls ommatidial rotation in the Drosophila compound eye. [FBrf0155677] Lee et al., 1998, Genetics 150(2): 663--673 Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. [FBrf0104762]
Personal communication to FlyBase	Mlodzik, 2000.1.26, sca-GAL4 lines. sca-GAL4 lines. [FBrf0125098]

Allele Dmel\sca73-1

Allele Dmel\sca^73-1