FlyBase Allele Report: Dmel\msl-1[L60]

General Information

Symbol

Dmel\msl-1^L60

Species

D. melanogaster

Name

FlyBase ID

FBal0093825

Feature type

allele

Associated gene

Dmel\msl-1

Associated Insertion(s)

Carried in Construct

Also Known As

msl1^L60

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Chang and Kuroda, 1998)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

2kb deletion beginning in the 5' UTR and deleting most of the coding region.

(Chang and Kuroda, 1998)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | male (with msl-1^AFG)

(Prabhakaran and Kelley, 2010)

lethal | male (with msl-1^F979Z)

(Prabhakaran and Kelley, 2010)

lethal | male (with msl-1^K1009X)

(Prabhakaran and Kelley, 2010)

lethal | male (with msl-1^P864L)

(Lim and Kelley, 2013, Prabhakaran and Kelley, 2010)

lethal | male (with msl-1^S943F)

(Lim and Kelley, 2013, Prabhakaran and Kelley, 2010)

lethal | male | recessive

(Prabhakaran and Kelley, 2010)

lethal | male limited (with msl-1^γ269)

(Hallacli et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

msl-1^L60 does not increase the fraction of red eye tissue present in males homozygous for P{GMroX1}75C.

(Prabhakaran and Kelley, 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

msl-1^L60/msl-1^P864L has lethal | male phenotype, suppressible | partially by ocm^L1658N/ocm^L1658N

(Lim and Kelley, 2013)

msl-1^S943F/msl-1^L60 has lethal | male phenotype, suppressible | partially by ocm^L1658N/ocm^L1658N

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has lethal | male phenotype, suppressible | partially by ocm^Q1297X/ocm[+]

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has lethal | male phenotype, suppressible | partially by ocm[+]/ocm^G1646E

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has lethal | male phenotype, suppressible | partially by ocm^S1590F/ocm[+]

(Lim and Kelley, 2013)

Enhancer of

Statement

Reference

msl-1^L60/msl-1[+] is an enhancer of partially lethal | male phenotype of Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9

(Prabhakaran and Kelley, 2012)

msl-1^L60/msl-1[+] is an enhancer | maternal effect of partially lethal - majority die | dominant | female phenotype of sc^sisB-1, sisA[+]/sisA¹

(Gladstein et al., 2010)

Suppressor of

Statement

Reference

msl-1^L60/msl-1[+] is a suppressor | partially of lethal | male phenotype of ocm^L1658N/ocm^G1646E

(Lim and Kelley, 2013)

Other

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, ocm^Q1297X/ocm[+], lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, ocm[+]/ocm^G1646E, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60, ocm^S1590F/ocm[+], lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, msl-1^L60/msl-1[+], lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has lethal | male phenotype

(Prabhakaran and Kelley, 2012)

Sxl[+]/Sxl^fP7B0, msl-1^L60 has partially lethal - majority die | female | maternal effect phenotype

(Gladstein et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The viability of Sxl^fP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-1^L60. One maternally-derived copy of msl-1^L60 significantly reduces the viability of sc^sisB-1 sisA¹/+ females so that they show almost complete lethality. One paternally-derived copy of msl-1^L60 significantly reduces the viability of sc^sisB-1 sisA¹/+ females.

(Gladstein et al., 2010)

The ability of P{GMroX1}75C (which carries roX1^t4.9) to partially rescue the lethality of roX1^ex6/Df(1)52 males is suppressed if the males are also heterozygous for msl-1^L60.

(Prabhakaran and Kelley, 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

msl-1^L60/msl-1^γ269 is rescued by Scer\GAL4^αTub84B.PL/msl-1^UAS.Tag:FLAG

(Hallacli et al., 2012)

Not rescued by

msl-1^L60/msl-1^γ269 is not rescued by msl-1^{mut1.UAS.Tag:FLAG}/Scer\GAL4^αTub84B.PL

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by Scer\GAL4^αTub84B.PL/msl-1^{mut3.UAS.Tag:FLAG}

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by Scer\GAL4^αTub84B.PL/msl-1^{mut4.UAS.Tag:FLAG}

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by msl-1^{mut5.UAS.Tag:FLAG}/Scer\GAL4^αTub84B.PL

(Hallacli et al., 2012)

Comments

Expression of msl-1^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^αTub84B.PL at 25[o]C completely rescues the male-specific lethality of msl-1^L60/msl-1^γ269 flies. Expression of either msl-1^{mut1.Scer\UAS.T:Zzzz\FLAG}, msl-1^{mut3.Scer\UAS.T:Zzzz\FLAG}, msl-1^{mut4.Scer\UAS.T:Zzzz\FLAG} or msl-1^{mut5.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^αTub84B.PL at 25[o]C fails to rescue the male-specific lethality of msl-1^L60/msl-1^γ269 flies.

(Hallacli et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

msl-1^L60

(Gladstein et al., 2010, Kotlikova et al., 2006)

msl1^L60

(Lim and Kelley, 2013, Hallacli et al., 2012, Prabhakaran and Kelley, 2012, Laverty et al., 2011, Prabhakaran and Kelley, 2010, Schiemann et al., 2010, Schiemann et al., 2010, Li et al., 2005, Bai et al., 2004, Rattner and Meller, 2004, Meller, 2003, Jin et al., 2000, Chang and Kuroda, 1998)

Name Synonyms

Secondary FlyBase IDs

References (15)

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