Allele Dmel\shot^V104

General Information
Symbol	Dmel\shot^V104	Species	D. melanogaster
Name		FlyBase ID	FBal0093958
Feature type	allele	Associated gene	Dmel\shot

Allele class
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	X ray (Walsh and Brown, 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Chromosomal rearrangement in the 3' end region of the gene, producing a truncated protein. (Strumpf and Volk, 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Walsh and Brown, 1998) visible \| somatic clone (Walsh and Brown, 1998)
Phenotype Manifest In
	embryonic/first instar larval cuticle \| dorsal (Walsh and Brown, 1998) embryonic/larval somatic muscle (Gregory and Brown, 1998, Strumpf and Volk, 1998) embryonic epidermis (Strumpf and Volk, 1998) muscle attachment site (Strumpf and Volk, 1998) wing \| somatic clone (Walsh and Brown, 1998)
Detailed Description
	Statement Reference The muscles pull away from the epidermis in homozygous embryos, but remain attached to each other. (Gregory and Brown, 1998) shot^V104/shot^A405 embryos have an excess of epidermal muscle attachment cells at a number of sites in the epidermis. The embryos have a significant disruption of the muscle pattern; in many cases individual myotubes are not oriented correctly and in some cases the myotubes round up. (Strumpf and Volk, 1998) Homozygous clones in the wing produce wing blisters. Blisters are associated with both dorsal and ventral clones. The pattern of veins and trichome polarity is normal, and there is no overgrowth or disruption to the overall wing shape and pattern. Mutant embryos show dramatic defects, including a dorsal open or tail-up phenotype. (Walsh and Brown, 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement Reference shot^V104/shot[+] is a non-enhancer of wing phenotype of if³ (Walsh and Brown, 1998) shot^V104/shot[+] is a non-enhancer of wing phenotype of mew^A1-5 (Walsh and Brown, 1998) shot^V104/shot[+] is a non-enhancer of wing phenotype of mys⁸ (Walsh and Brown, 1998)
Additional Comments
Genetic Interactions
Statement Reference Does not dominantly enhance the frequency of wing blisters in if³, mew^A1-5 or mys⁸ hemizygotes. (Walsh and Brown, 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	shot^A405 (Strumpf and Volk, 1998)
Comments
Stocks ( 1 )
Bloomington	8740 P{neoFRT}42D shot^V104/SM5
Notes on Origin
Discoverer
	Selected as: Mutation that produces wing blister in homozygous clones. (Walsh and Brown, 1998)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	kak^V104 kop^V104 (Walsh and Brown, 1998) shot^<up>V104</up> (Jiang and Edgar, 2009) shot^V104
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Jiang and Edgar, 2009, Development 136(3): 483--493 EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. [FBrf0206542] Gregory and Brown, 1998, J. Cell Biol. 143(5): 1271--1282 kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin. [FBrf0105832] Strumpf and Volk, 1998, J. Cell Biol. 143(5): 1259--1270 Kakapo, a novel cytoskeletal-associated protein is essential for the restricted localization of the neuregulin-like factor, vein, at the muscle-tendon junction site. [FBrf0105940] Walsh and Brown, 1998, Genetics 150(2): 791--805 A screen to identify Drosophila genes required for integrin-mediated adhesion. [FBrf0104793]

Allele Dmel\shotV104

Allele Dmel\shot^V104