Allele Dmel\elB^EP2039

General Information
Symbol	Dmel\elB^EP2039	Species	D. melanogaster
Name		FlyBase ID	FBal0093970
Feature type	allele	Associated gene	Dmel\elB
Also Known As	EP(2)2039

Map ( GBrowse )	Untitled Document
Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Roote, 1998.11.16)
Mutagen	P-element activity (Roote, 1998.11.16, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Abdelilah-Seyfried et al., 2000, Gene Disruption Project members, 2001-, Dorfman et al., 2002, Tseng and Hariharan, 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:14,409,608..14,409,608 (Roote, 1998.11.16, Dorfman et al., 2002, Tseng and Hariharan, 2002, Weihe et al., 2004, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Abdelilah-Seyfried et al., 2000, Gene Disruption Project members, 2001-, Ashburner et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP} insertion 965bp upstream of the 5' UTR and 1365bp upstream of the translation start site of elB. (Dorfman et al., 2002) P{EP} insertion at the 5' end of the predicted BG:DS06238.3 gene. (Ashburner et al., 1999) P{EP} insertion at position 45657 of DS06238. (Ashburner et al., 1999.10.12)
Caused by insertion	P{EP}elB^EP2039 (Roote, 1998.11.16, Dorfman et al., 2002, Tseng and Hariharan, 2002, Weihe et al., 2004, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Abdelilah-Seyfried et al., 2000, Gene Disruption Project members, 2001-, Ashburner et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal, with Scer\GAL4^btl.PS (Dorfman et al., 2002) lethal, with Scer\GAL4^en-e16E (Tseng and Hariharan, 2002) viable, with Scer\GAL4[-]: (Dorfman et al., 2002) visible, with Scer\GAL4^ey.PH (Tseng and Hariharan, 2002) visible \| recessive, with Scer\GAL4[-]: (Ashburner et al., 1999)
Phenotype Manifest In
	dorsal branch primordium, with Scer\GAL4^btl.PS (Dorfman et al., 2002) eye, with Scer\GAL4^ey.PH (Tseng and Hariharan, 2002) transverse connective primordium, with Scer\GAL4^btl.PS (Dorfman et al., 2002) visceral branch primordium, with Scer\GAL4^btl.PS (Dorfman et al., 2002)
Detailed Description
	Statement Reference The visceral branch of the tracheal system is not formed in most segments in embryos expressing elB^EP2039 under the control of Scer\GAL4^btl.PS. The cells which normally form the visceral branch remain in the central region of the transverse connective branch. The dorsal branch generally contains more cells than normal. The number of cells in the lateral trunk anterior branch normal in these embryos. (Dorfman et al., 2002) Expression of elB^EP2039 under the control of Scer\GAL4^ey.PH results in eyes that are strongly reduced in size. Flies expressing elB^EP2039 under the control of Scer\GAL4^hs.2sev have wild-type eyes. Cells from third larval instar wing discs expressing elB^EP2039 under the control of Scer\GAL4^Act5C.PP are normal in size. There is a small but reproducible increase in the G2/M population. (Tseng and Hariharan, 2002) Weak allele. (Ashburner et al., 1999) Shows an "elbow" phenotype when hemizygous. (Ashburner et al., 1999.10.12) Shows a very weak elbow phenotype Df(2L)A217. (Roote, 1998.11.16)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^ey.PH, elB^EP2039 has visible phenotype, suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Tseng and Hariharan, 2002)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^ey.PH, elB^EP2039 has eye phenotype, suppressible by CycE^Scer\UAS.cLa, Scer\GAL4^ey.PH (Tseng and Hariharan, 2002)
Enhancer of
Statement Reference elB^EP2039/Scer\GAL4[-] is an enhancer of phenotype of noc^Sco (Ashburner et al., 1999)
Other
Statement Reference Scer\GAL4^btl.PS, elB^EP2039, tkv^{Q253D.Scer\UAS.cLa} has lateral trunk anterior branch phenotype (Dorfman et al., 2002, Dorfman et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of both elB^EP2039 and tkv^{Q253D.Scer\UAS.cLa} under the control of Scer\GAL4^btl.PS results in an excess of lateral trunk anterior branch cells in the embryo. (Dorfman et al., 2002) Co-expression of CycE^Scer\UAS.cLa suppresses the small eye phenotype caused by expression of elB^EP2039 under the control of Scer\GAL4^ey.PH. Cells from third larval instar wing discs expressing elB^EP2039 under the control of Scer\GAL4^Act5C.PP (and also co-expressing BacA\p35^Scer\UAS.cHa to eliminate cell death) have a 26% longer doubling time than control cells expressing BacA\p35^Scer\UAS.cHa alone under the control of Scer\GAL4^Act5C.PP. (Tseng and Hariharan, 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Excision of the P{EP} element can revert the mutant phenotype. (Ashburner et al., 1999) Excisions of the P{EP} element can result in reversion of the elB phenotype. (Ashburner et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	elB^EP2039 EP(2)2039 (Abdelilah-Seyfried et al., 2000, Ashburner et al., 1999.10.12, Ashburner et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Weihe et al., 2004, Development 131(4): 767--774 Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex. [FBrf0174589] Dorfman et al., 2002, Development 129(15): 3585--3596 Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches. [FBrf0151266] Tseng and Hariharan, 2002, Genetics 162(1): 229--243 An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. [FBrf0152035] Abdelilah-Seyfried et al., 2000, Genetics 155(2): 733--752 A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. [FBrf0128367] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326]
Supplementary material	Ashburner et al., 1999, Genetics 153(1): Table S1. P-element insertions in the Adh region. [FBrf0112150]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Roote, 1998.11.16, New P alleles. New P alleles. [FBrf0105416]

Allele Dmel\elBEP2039

Allele Dmel\elB^EP2039