FlyBase Allele Report: Dmel\cnk[hs.sev.Tag:FLAG]

General Information

Symbol

Dmel\cnk^{hs.sev.Tag:FLAG}

Species

D. melanogaster

Name

FlyBase ID

FBal0093975

Feature type

allele

Associated gene

Dmel\cnk

Associated Insertion(s)

Carried in Construct

P{sE-cnk.FLAG}

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Therrien et al., 1998)

in vitro construct - coding region fusion

(Therrien et al., 1998)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{sE-cnk.FLAG}

Cytology

Nature of the lesion

Statement

Reference

Full length cnk cDNA tagged with Tag:FLAG is expressed from the dual sev enhancer Hsp70 promoter.

(Therrien et al., 1998)

Allele components

Product class / Tool use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

cnk

Tagged with

Tag:FLAG

epitope tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

visible

(Therrien et al., 1999, Therrien et al., 1998)

Phenotype Manifest In

eye

(Therrien et al., 1999, Therrien et al., 1998)

photoreceptor

(Therrien et al., 1998)

photoreceptor cell R7

(Therrien et al., 1998)

Detailed Description

Statement

Reference

Mutant eyes appear wild-type - ommatidial organisation is normal.

(Laberge et al., 2005)

Eye surface is roughened.

(Therrien et al., 1999)

Mild rough eye phenotype, with the anterior portion of the eye being more disorganised. R7 and outer photoreceptors are missing.

(Therrien et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

cnk^{hs.sev.Tag:FLAG} is a non-enhancer of visible phenotype of Ras85D^V12.C40.UAS, Scer\GAL4^hs.2sev

(Therrien et al., 1999)

cnk^{hs.sev.Tag:FLAG} is a non-enhancer of visible phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^sev.EP

(Therrien et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

cnk^{hs.sev.Tag:FLAG} is an enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 1999, Therrien et al., 1998)

cnk^{hs.sev.Tag:FLAG} is an enhancer of eye phenotype of Ras85D^V12.G37.UAS, Scer\GAL4^hs.2sev

(Therrien et al., 1999)

Suppressor of

Statement

Reference

cnk^{hs.sev.Tag:FLAG} is a suppressor | partially of photoreceptor cell R7 | supernumerary phenotype of Ras85D^V12.sev

(Douziech et al., 2003)

cnk^{hs.sev.Tag:FLAG} is a suppressor of eye phenotype of Raf::tor^13D.hs.sev

(Therrien et al., 1999, Therrien et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The enhancement effect of Ras85D^{V12.G37.Scer\UAS} on cnk^{hs.sev.T:Zzzz\FLAG} contrasts sharply with the lack of enhancement of cnk^{hs.sev.T:Zzzz\FLAG} by Ras85D^{V12.S35.Scer\UAS} or Ras85D^{V12.C40.Scer\UAS}.

(Therrien et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cnk^{hs.sev.T:FLAG}

cnk^{hs.sev.T:Zzzz\FLAG}

cnk^{hs.sev.Tag:FLAG}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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