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General Information
Symbol
Dmel\sktlUAS.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0094337
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-sktl
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
Expression of a sktl cDNA is governed by UASt regulatory sequences.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Posterior dorsocentral bristle neurons expressing sktlUAS.cHa under the control of Scer\GAL4pnr-MD237 show a significantly decreased terminal arbor territory, as compared to controls.
When expression is driven by an elav-Scer\GAL4, no phenotype results. When expression is driven by Scer\GAL4da.G32 or a heat shock Scer\GAL4, no phenotype results but early larval lethality results. When expression is driven by Scer\GAL4T80 third instar larval lethality results. Expression driven by Scer\GAL4dpp.blk1 causes no eye phenotype but ectopic bristles on the notum and wing blade. When expression is driven by Scer\GAL432B ectopic bristles appear on the notum and wing blade. The ectopic bristles as well as the normal bristles show structural defects consistent with a role for sktl in the cytoskeleton. All ectopic bristles are associated with socket cells.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sktlScer\UAS.cHa
sktlUAS.cHa
Name Synonyms
Secondary FlyBase IDs
    References (5)