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General Information
Symbol
Dmel\Su(Tpl)s1
Species
D. melanogaster
Name
FlyBase ID
FBal0094491
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)76BDs1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate boundaries (+/-1bp) of a 17 nucleotide deletion that results in a frameshift and early translation termination. The amino acid sequence at the deletion site becomes DTHKNGHCRGDGEEQVHQGNQAESVGYRA@. The site of the deletion is calculated to begin in codon 147 of the reference sequence.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A 17 nucleotide deletion starting at codon 145 results in a frameshift.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The hetero-allelic combination Su(Tpl)s1/Su(Tpl)S-192 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance; abdominal segment 2 missing, incomplete or fused to abdominal segment 1; abdominal segment 6 broken or fused to abdominal segment 5; abdominal segment 8 missing. The hetero-allelic combination Su(Tpl)s1/Su(Tpl)XS-706 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance: fusion of abdominal segments 3 and 4; fusion of abdominal segments 5 and 6; abdominal segment 2 missing; abdominal segment 1 incomplete. The hetero-allelic combination Su(Tpl)s1/Su(Tpl)17 is embryonic lethal. Mutant cuticles display the following defects, with variable penetrance; abdominal segment 2 missing, incomplete or fused to abdominal segment 3; fusions of abdominal segments 3 to 4 and 4 to 5; incomplete abdominal segment 6.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

Su(Tpl)[+]/Su(Tpl)s1 is an enhancer of wing margin phenotype of Nnd-1

Su(Tpl)[+]/Su(Tpl)s1 is an enhancer of wing margin phenotype of ct53d

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)