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General Information
Symbol
Dmel\btl::tor4021.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0094564
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A chimeric construct consisting of the extracellular domain of the constitutively active tor13D mutant fused to the intracellular domain of btl is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

btl::tor4021.Scer\UAS Scer\GAL4αTub84B.PL somatic clones in the dorsal air sac primordium are larger than wild-type clones, forming bulky outgrowths. These clones never contribute to the primordium tip but show extremely dynamic cytoskeletal activity - forming large lamellopodia which extend away from the air sac, simlar to cells at the tip. (clones generated by Scer\GAL80 MARCM technique.)

Flies expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4Bx-MS1096 have larger wings than normal, with extra wing vein material and deltas at the wing margin.

Embryos expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in a wild-type background show excessive terminal branching in the tracheal system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Phenotype Manifest In
Suppressed by
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing phenotype see in flies expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4Bx-MS1096 is suppressed by coexpression of vapScer\UAS.T:Hsap\MYC.

Expression of btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in btlLG19 mutant embryos partially rescues tracheal cell migration, and additional tracheal branching is seen, as in embryos expressing btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in a wild-type background. Expression of btl::tor4021.Scer\UAS under the control of Scer\GAL4btl.PS in stumps09904b mutant embryos does not rescue tracheal migration defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
btl::tor4021.Scer\UAS
btl::tor4021.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)