Allele Dmel\Su(H)^{Scer\UAS.T:Hsap\MYC}

General Information
Symbol	Dmel\Su(H)^{Scer\UAS.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0094607
Feature type	allele	Associated gene	Dmel\Su(H)

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Kidd et al., 1998) in vitro construct - regulatory fusion (Kidd et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: The first 2 amino acids of cact followed by T:Hsap\MYC is fused to amino acid 10 of Su(H) coding region. (Kidd et al., 1998)
Carried in construct	P{UAS-Su(H).myc} (Apitz et al., 2005, Kidd et al., 1998, Duan et al., 2011, Ren et al., 2011)
Tagged with	T:Hsap\MYC (Kidd et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^Eq1 (Duan et al., 2011)
Phenotype Manifest In
	chaeta, with Scer\GAL4^Eq1 (Duan et al., 2011)
Detailed Description
	Statement Reference Expression of Su(H)[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[Eq1] results in a substantial balding phenotype on the notum. (Duan et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^Eq1, Su(H)^{Scer\UAS.T:Hsap\MYC} has visible phenotype, enhanceable by insv^unspecified (Duan et al., 2011)
Suppressor of
Statement Reference Su(H)^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PU is a suppressor \| partially of visible phenotype of Hsap\TBP^80Q.Scer\UAS, Scer\GAL4^GMR.PU (Ren et al., 2011)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^Eq1, Su(H)^{Scer\UAS.T:Hsap\MYC} has chaeta phenotype, enhanceable by insv^unspecified (Duan et al., 2011)
Suppressor of
Statement Reference Su(H)^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PU is a suppressor \| partially of eye phenotype of Hsap\TBP^80Q.Scer\UAS, Scer\GAL4^GMR.PU (Ren et al., 2011) Su(H)^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PU is a suppressor \| partially of ommatidium phenotype of Hsap\TBP^80Q.Scer\UAS, Scer\GAL4^GMR.PU (Ren et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference insv[unspecified] enhances the notum balding phenotype caused by expression of Su(H)[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[Eq1]. (Duan et al., 2011)
Xenogenetic Interactions
Statement Reference Overexpression of Su(H)[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PU] partially suppresses the eye abnormalities caused by the overexpression of Hsap\TBP[80Q.Scer\UAS] with an improvement in both the shape and organisation of ommatidia. Ommatidial fusion is no longer observed and pigment loss is less severe. (Ren et al., 2011)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	5814 w^*; P{UAS-Su(H).myc}l(2)SK1^SK1/In(2LR)Gla, wg^Gla-1
Notes on Origin
Discoverer

Comments
	Carried in plasmid and used in S2 cells as well as transgenic Drosophila. (Kidd et al., 1998)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Su(H)^{Scer\UAS.T:Hsap\MYC} Su(H)^UAS.T:Myc
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Duan et al., 2011, EMBO J. 30(15): 3120--3133 Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. [FBrf0214638] Ren et al., 2011, Hum. Mol. Genet. 20(17): 3424--3436 A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. [FBrf0214639] Apitz et al., 2005, Dev. Genes Evol. 215(9): 460--469 Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster. [FBrf0190252] Kidd et al., 1998, Genes Dev. 12(23): 3728--3740 Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. [FBrf0105862]

Allele Dmel\Su(H)Scer\UAS.T:Hsap\MYC

Allele Dmel\Su(H)^{Scer\UAS.T:Hsap\MYC}