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General Information
Symbol
Dmel\Mi-24
Species
D. melanogaster
Name
FlyBase ID
FBal0094646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dMi-24
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
insertion
Comment:

Insertion of 4 bases (GGCA) after codon 398 causes a frameshift and leads to early translation termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of 4bp after codon 398, resulting in a frameshift and a predicted premature termination within the first PHD finger domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The lethality caused by expression of Mi-2Δ932-1158.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4da.G32 is strongly enhanced by Mi-24/+.

Heterozygotes have completely normal eyes.

Homozygous female germline clones do not produce any eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Mi-24/Mi-2[+] is an enhancer of visible phenotype of HDAC11-3, ttkrM730

Mi-24/Mi-2[+] is an enhancer of visible phenotype of HDAC13-10, ttkrM730

Mi-24/Mi-2[+] is an enhancer of visible phenotype of HDAC15-5, ttkrM730

Mi-24/Mi-2[+] is an enhancer of visible | dominant | homeotic phenotype of Pc4

Suppressor of
Statement
Reference

Mi-24/Mi-2[+] is a suppressor of visible | dominant phenotype of Nipped-B407

Other
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

Mi-24 has phenotype, non-enhanceable by Alhunspecified

NOT suppressed by
Statement
Reference

Mi-24 has phenotype, non-suppressible by Alhunspecified

Enhancer of
Statement
Reference

Mi-24/Mi-2[+] is an enhancer of wing sensillum | ectopic phenotype of HDAC11-3, ttkrM730

Mi-24/Mi-2[+] is an enhancer of wing sensillum | ectopic phenotype of HDAC13-10, ttkrM730

Mi-24/Mi-2[+] is an enhancer of wing sensillum | ectopic phenotype of HDAC15-5, ttkrM730

Mi-24/Mi-2[+] is an enhancer of mesothoracic leg phenotype of Pc4

Mi-24/Mi-2[+] is an enhancer of metathoracic leg phenotype of Pc4

Mi-24/Mi-2[+] is an enhancer of sex comb | ectopic phenotype of Pc4

Suppressor of
Statement
Reference

Mi-24/Mi-2[+] is a suppressor of wing blade phenotype of Nipped-B407

Other
Additional Comments
Genetic Interactions
Statement
Reference

Mi-24/+ suppresses the reduction in wing blade area seen in Nipped-B407/+ flies.

MBD-likeEY04582/Mi-24 double heterozygotes have significantly smaller and rougher eyes than normal.

The number of neurons associated with the pentascolopidial sensory organ in ttkrM730 mutant embryos is significantly increased if they are also mutant for Mi-24.

The formation of extra sex combs on the second and third legs in Pc4/+ flies is dominantly enhanced by Mi-24.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

74% of Mi-24 homozygotes are rescued to adulthood by expression of Mi-2Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4da.G32.

The egg laying phenotype is rescued by Mi-2arm.PK; normally shaped eggs are produced, but no embryos are obtained.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)