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General Information
Symbol
Dmel\NECNΔ10-12.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0094667
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UASECNΔ10-12
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Deletion of N amino acids 412 to 566 inclusive, fusing EGF-like repeats 9 and 14, while maintaining the structural integrity of the remaining EGF-like repeats.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of NECNΔ10-12.Scer\UAS under the control of Scer\GAL4ptc-559.1 results in a fusion between wing veins 3 and 4.

When expression of NECNΔ10-12.Scer\UAS is driven by Scer\GAL4sd-SG29.1 the wing disc has a small wing pouch. Adult wings lack the majority of both the anterior and posterior wing margin.

Expression of NECNΔ10-12.Scer\UAS driven by Scer\GAL4ptc-559.1 results in a reduction in cell number in those proneural clusters in the wing disc that are fated to become scutellar bristles, but not those fated to become dorsocentral bristles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Suppressor of
Statement
Reference

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a suppressor | partially of anterior notopleural bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a suppressor | partially of posterior postalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a suppressor | partially of posterior dorsocentral bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NOT Suppressor of
Statement
Reference

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a non-suppressor of presutural bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a non-suppressor of anterior supraalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a non-suppressor of anterior postalar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a non-suppressor of anterior scutellar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

NECNΔ10-12.UAS, Scer\GAL4l(3)31-1-31-1 is a non-suppressor of posterior scutellar bristle & trichogen cell phenotype of DlUAS.cJa, Scer\GAL4l(3)31-1-31-1

Other
Statement
Reference

NECNΔ10-12.UAS, Scer\GAL4sd-SG29.1, wgUAS.cGa has sensory mother cell & dorsal mesothoracic disc | ectopic phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The wing phenotype caused by expression of SerScer\UAS.cSa under the control of Scer\GAL4ptc-559.1 is suppressed by coexpression of NECNΔ10-12.Scer\UAS. The wing phenotype caused by expression of DlScer\UAS.cHa under the control of Scer\GAL4ptc-559.1 is not suppressed by coexpression of NECNΔ10-12.Scer\UAS.

The addition of wgl-12.Scer\UAS restores the wing pouch and adult wing almost to wild-type in animals expressing NECNΔ10-12.Scer\UAS driven by Scer\GAL4sd-SG29.1. When expression of NECNΔ10-12.Scer\UAS and wgScer\UAS.cGa are driven by Scer\GAL4sd-SG29.1 the whole of the anterior compartment of the wing disc is covered in evenly spaced SOPs (sensory organ precursors).

The addition of Su(H)8/Su(H)2 does not affect the phenotype caused by expression of NECNΔ10-12.Scer\UAS driven by Scer\GAL4ptc-559.1. The loss of proneural precursors and sensory organ phenotypes normally seen in NECNΔ10-12.Scer\UAS/Scer\GAL4ptc-559.1 flies is suppressed in sggM11 somatic clones.

Coexpression of NECNΔ10-12.Scer\UAS fails to suppress the transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by DlScer\UAS.cJa expressed under the control of Scer\GAL4l(3)31-1-31-1 in the presutural, anterior supraalar, anterior postalar, anterior scutellar and posterior scutellar bristles. Transformation of the trichogen to a tormogen fate in the anterior notopleural, posterior postalar and posterior dorsocentral bristles is slightly reduced in these flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
NECNΔ10-12.Scer\UAS
NECNΔ10-12.UAS
Name Synonyms
Secondary FlyBase IDs
    References (4)