FlyBase Allele Report: Scer\GAL4[tim.PE]

Expression of Scer\GAL4^tim.PE is seen in cells near sensilla on the head capsule, thorax and abdomen of the adult. Expression of Scer\GAL4^tim.PE in seen within the abdominal portion of the adult midgut. Expression in the mouth is restricted to the posterior region.

(Kaneko and Hall, 2000)

Marker for

Reflects expression of

tim

(Chen et al., 2012, Ruiz et al., 2010, Helfrich-Forster et al., 2007, Hamasaka and Nassel, 2006, Kaneko and Hall, 2000, Emery et al., 1998)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior, with Scer\GAL80^Pdf.PS, sgg^EP1576

(Stoleru et al., 2007)

abnormal behavior, with sgg^EP1576

(Stoleru et al., 2007)

abnormal circadian behavior, with Atx2^KK100423

(Zhang et al., 2013)

abnormal circadian behavior, with dom^HMC04203

(Liu et al., 2019)

abnormal circadian behavior, with dom^HMC04451

(Liu et al., 2019)

abnormal circadian behavior, with dom^HMS01855

(Liu et al., 2019)

abnormal circadian behavior, with dom^JF01502

(Liu et al., 2019)

abnormal circadian behavior, with Mocs2B^KK101263

(Marelja et al., 2018)

abnormal circadian behavior, with na^KK102435

(Lear et al., 2013)

abnormal circadian behavior, with Scer\GAL80^cry.PS, Shaw^{dsRNA.Sym.UAS.cHa}

(Hodge and Stanewsky, 2008)

abnormal circadian behavior, with Scer\GAL80^Pdf.PS, dom^HMC04203

(Liu et al., 2019)

abnormal circadian behavior, with Scer\GAL80^Pdf.PS, dom^HMC04451

(Liu et al., 2019)

abnormal circadian behavior, with unc79^KK102682

(Lear et al., 2013)

abnormal circadian behavior, with unc80^KK101371

(Lear et al., 2013)

abnormal circadian behavior | adult stage, with Hsap\KCNS2^D379E.UAS

(Smith et al., 2018)

abnormal circadian behavior | adult stage, with Hsap\KCNS2^UAS.cSa

(Smith et al., 2018)

abnormal circadian behavior | adult stage, with Hsap\NRXN1^{I1135V.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal circadian behavior | adult stage, with Hsap\NRXN1^{L893V.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal circadian behavior | adult stage, with Hsap\NRXN1^{WT.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal circadian behavior | adult stage, with Hsap\NRXN1^{Y282H.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal circadian behavior | adult stage, with pn^HMC06185

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with Scer\GAL80^Pdf.PS, pn^HMC06185

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with Scer\GAL80^Pdf.PS, TFAM^JF02307

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with Scer\GAL80^Pdf.PS, TFAM^UAS.cCa

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with TFAM^JF02307

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with TFAM^UAS.cCa

(Chen et al., 2019)

abnormal circadian behavior | adult stage, with Xvas\XhoI^{UASp.Tag:Mito(kdn),Tag:MYC}

(Chen et al., 2019)

abnormal circadian rhythm, with 5-HT1B^dsRNA.UAS

(Yuan et al., 2005, Yuan et al., 2005)

abnormal circadian rhythm, with 5-HT1B^UAS.cYa

(Yuan et al., 2005)

abnormal circadian rhythm, with Clk^{Δ.UAS.Tag:HA}

(Tanoue et al., 2004)

abnormal circadian rhythm, with cry^UAS.cEa

(Emery et al., 2000, Emery et al., 1998)

abnormal circadian rhythm, with ctrip^NIG.14656R

(Lamaze et al., 2011)

abnormal circadian rhythm, with ctrip^NIG.14656R, ctrip^NIG.17735R

(Lamaze et al., 2011)

abnormal circadian rhythm, with ctrip^NIG.17735R

(Lamaze et al., 2011)

abnormal circadian rhythm, with cyc^{Δ.UAS.Tag:MYC}

(Tanoue et al., 2004)

abnormal circadian rhythm, with dco^{K38R.UAS.cVa.Tag:MYC}

(Venkatesan et al., 2015)

abnormal circadian rhythm, with dco^{K38R.UAS.Tag:MYC,Tag:NLS(SV40-largeT)}

(Venkatesan et al., 2015)

abnormal circadian rhythm, with dco^{NLS-.UAS.Tag:MYC}

(Venkatesan et al., 2015)

abnormal circadian rhythm, with Scer\GAL80^cry.PS, Shaw^{dsRNA.Sym.UAS.cHa}

(Hodge and Stanewsky, 2008)

abnormal circadian rhythm, with Scer\GAL80^cry.PS, Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal circadian rhythm, with Scer\GAL80^Pdf.PS, sgg^EP1576

(Stoleru et al., 2005)

abnormal circadian rhythm, with Scer\GAL80^Pdf.PS, Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal circadian rhythm, with sgg^EP1576

(Stoleru et al., 2005)

abnormal circadian rhythm, with sgg^S9A.UAS

(Wolf et al., 2007)

abnormal circadian rhythm, with sgg^UAS.cBa

(Wolf et al., 2007, Yuan et al., 2005)

abnormal circadian rhythm, with Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal circadian rhythm, with shn^UAS.cMa

(Beckwith et al., 2013)

abnormal circadian rhythm, with tyf^G10872

(Lim et al., 2011)

abnormal circadian rhythm | adult stage, with cac^KK101478

(Hidalgo et al., 2021)

abnormal circadian rhythm | adult stage, with cbt^UAS.Tag:FLAG

(Bartok et al., 2015)

abnormal circadian rhythm | adult stage, with Cipc^KK104160

(Rivas et al., 2021)

abnormal circadian rhythm | adult stage, with Cipc^{UAS.ORF.GW.Tag:HA}

(Rivas et al., 2021)

abnormal circadian rhythm | adult stage, with NKCC^NIG.2509R

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with NKCC^{UAS.Tag:FLAG,Tag:HA}

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with qsm^dsRNA.UAS

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with qsm^GD4817

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with qsm^UAS.cCa

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with scro^UAS.Tag:HA

(Nair et al., 2020)

abnormal circadian rhythm | adult stage, with scro^{ΔNK2.UAS.Tag:HA}

(Nair et al., 2020)

abnormal circadian rhythm | adult stage, with scro^{ΔTN.UAS.Tag:HA}

(Nair et al., 2020)

abnormal circadian rhythm | adult stage, with Shaw^{dsRNA.Sym.UAS.cHa}

(Buhl et al., 2016)

abnormal circadian rhythm | adult stage, with Shaw^{RA.UAS.Tag:FLAG}

(Buhl et al., 2016)

abnormal circadian rhythm | conditional, with Spyo\Cas9^UAS.P2, per^{UAS.gRNAx4.pCFD6}

(Delventhal et al., 2019)

abnormal circadian rhythm | conditional, with Spyo\Cas9^UAS.P2, tim^{UAS.gRNAx3.pCFD6}

(Delventhal et al., 2019)

abnormal circadian rhythm | heat sensitive, with Actβ^JF03276, Scer\GAL80^Pdf.PS

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, daw^KK110248

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, dpp^HMS00011

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, gbb^HMS01243

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, mav^HMS01125

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, myo^JF01717

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, scw^KK109520

(Beckwith et al., 2013)

abnormal circadian rhythm | heat sensitive, with Scer\GAL80^Pdf.PS, shn⁷⁵⁶

(Beckwith et al., 2013)

abnormal eclosion rhythm, with cyc^{Δ.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with dco^{L.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with dco^{S.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with lark^UAS.Tag:HA

(Schroeder et al., 2003)

abnormal eclosion rhythm, with Scer\GAL80^phm.1.2, cyc^{Δ.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with Scer\GAL80^phm.1.2, dco^{L.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with Scer\GAL80^phm.1.2, dco^{S.UAS.Tag:MYC}

(Selcho et al., 2017)

abnormal eclosion rhythm, with Scer\GAL80^phm.1.2, tim^UAS.cUa

(Selcho et al., 2017)

abnormal eclosion rhythm, with tim^UAS.cUa

(Selcho et al., 2017)

abnormal eclosion rhythm, with tor^GD14396

(Selcho et al., 2017)

abnormal locomotor behavior, with spag^{dsRNA.UAS.cUa}

(Means et al., 2015)

abnormal locomotor behavior | adult stage, with cac^KK101478

(Hidalgo et al., 2021)

abnormal locomotor behavior | adult stage, with cbt^UAS.Tag:FLAG

(Bartok et al., 2015)

abnormal locomotor rhythm, with Bdbt^GD9337

(Fan et al., 2013)

abnormal locomotor rhythm, with Bdbt^KK102995

(Fan et al., 2013)

abnormal locomotor rhythm, with Cat^GD1291

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with CG1358^KK109206

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with CG4858^KK100349

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with CG8043^KK107835

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with CkIIα^UAS.cLa

(Lin et al., 2005)

abnormal locomotor rhythm, with Clk^{Δ.UAS.Tag:HA}

(Tanoue et al., 2004)

abnormal locomotor rhythm, with cry^{dsRNA.UAS.cPa}

(Picot et al., 2007)

abnormal locomotor rhythm, with Ctet\tetX^TNT-LC.UAS

(Kaneko et al., 2000)

abnormal locomotor rhythm, with ctrip^miRNA.UAS

(Sathyanarayanan et al., 2008)

abnormal locomotor rhythm, with cu^NIG.31299R

(Nagoshi et al., 2010)

abnormal locomotor rhythm, with Cul3^{K717R.UAS.GFP}

(Grima et al., 2012)

abnormal locomotor rhythm, with Cul3^{KR.Scer\UAS.Tag:FLAG}

(Grima et al., 2012)

abnormal locomotor rhythm, with Cul3^WT.UAS.GFP

(Grima et al., 2012)

abnormal locomotor rhythm, with Cul3^ΔC.UAS

(Grima et al., 2012)

abnormal locomotor rhythm, with cwo^dsRNA.UAS

(Lim et al., 2007)

abnormal locomotor rhythm, with cyc^VP16.UAS

(Kadener et al., 2008)

abnormal locomotor rhythm, with cyc^{Δ.UAS.Tag:MYC}

(Sehadova et al., 2009, Tanoue et al., 2004)

abnormal locomotor rhythm, with dco^{K38R.UAS.Tag:MYC}

(Fan et al., 2013, Muskus et al., 2007)

abnormal locomotor rhythm, with dco^{L.UAS.Tag:MYC}

(Muskus et al., 2007)

abnormal locomotor rhythm, with dco^{S.UAS.Tag:MYC}

(Muskus et al., 2007)

abnormal locomotor rhythm, with dco^{Tau.UAS.Tag:MYC}

(Fan et al., 2009)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, gw^HMS00105

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, gw^KK101472

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Gαs^JF03255

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Pka-C1^GL00038

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Pka-C1^JF01188

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Pka-C1^JF01218

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with Dcr-2^UAS.cDa, Scer\GAL80^Pdf.PS, gw^KK101472

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with dnc^UAS.cCa

(Zhang and Emery, 2013)

abnormal locomotor rhythm, with FeCH^KK108873

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with Fer2LCH^GD6348

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with Fer2LCH^KK103577

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with fh^dsRNA.IR.UAS

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with Fmr1^EP3517

(Dockendorff et al., 2002)

abnormal locomotor rhythm, with Fmr1^NE3-4

(Dockendorff et al., 2002)

abnormal locomotor rhythm, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Kadener et al., 2006)

abnormal locomotor rhythm, with ITP^UAS.cHa

(Hermann-Luibl et al., 2014)

abnormal locomotor rhythm, with lark^UAS.Tag:HA

(Schroeder et al., 2003)

abnormal locomotor rhythm, with MagR^KK109272

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with mir-279^NE95-11-24

(Luo and Sehgal, 2012)

abnormal locomotor rhythm, with mir-279^UAS.L

(Luo and Sehgal, 2012)

abnormal locomotor rhythm, with mir-279^UAS.S

(Luo and Sehgal, 2012)

abnormal locomotor rhythm, with mir-ban^EP3622

(Kadener et al., 2009)

abnormal locomotor rhythm, with mts^dn181.UAS

(Sathyanarayanan et al., 2004)

abnormal locomotor rhythm, with mts^UAS.cHa

(Sathyanarayanan et al., 2004)

abnormal locomotor rhythm, with mub^KK108209

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with na^UAS.cLa

(Lear et al., 2005)

abnormal locomotor rhythm, with Nfs1^KK101134

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with nocte^dsRNA.1.UAS

(Sehadova et al., 2009)

abnormal locomotor rhythm, with per^dsRNA.Ct.UAS

(Martinek and Young, 2000)

abnormal locomotor rhythm, with per^{dsRNA.PAS.UAS}

(Ng et al., 2011, Martinek and Young, 2000)

abnormal locomotor rhythm, with per^UAS.cKa

(Kaneko et al., 2000)

abnormal locomotor rhythm, with per^UAS.cYa

(Yang and Sehgal, 2001)

abnormal locomotor rhythm, with qsm^dsRNA.UAS

(Chen et al., 2011)

abnormal locomotor rhythm, with qsm^GD4817

(Chen et al., 2011)

abnormal locomotor rhythm, with Scer\GAL80^cry.PS, Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, cry^{dsRNA.UAS.cPa}

(Picot et al., 2007)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, per^UAS.cKa

(Stoleru et al., 2007)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, per^UAS.cYa

(Stoleru et al., 2007)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, sgg^EP1576

(Stoleru et al., 2007)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal locomotor rhythm, with Scer\GAL80^Pdf.PS, tim^UAS.cYa

(Stoleru et al., 2007)

abnormal locomotor rhythm, with Scer\GAL80^ts.αTub84B, Usp8^DN.UAS

(Luo et al., 2012)

abnormal locomotor rhythm, with Scer\GAL80^ts.αTub84B, Usp8^dsRNA.2.UAS

(Luo et al., 2012)

abnormal locomotor rhythm, with sgg^EP1576

(Stoleru et al., 2007, Wülbeck et al., 2005)

abnormal locomotor rhythm, with sgg^UAS.cBa

(Martinek et al., 2001)

abnormal locomotor rhythm, with Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

abnormal locomotor rhythm, with slmb^{UAS.ΔFbox.Tag:MYC}

(Ko et al., 2002)

abnormal locomotor rhythm, with spag^{dsRNA.UAS.cUa}

(Means et al., 2015)

abnormal locomotor rhythm, with tim^UAS.cYa

(Yang and Sehgal, 2001)

abnormal locomotor rhythm, with Tsf3^KK109853

(Mandilaras and Missirlis, 2012)

abnormal locomotor rhythm, with upd1^NIG.5993R

(Luo and Sehgal, 2012)

abnormal locomotor rhythm, with upd1^UAS.cUa

(Luo and Sehgal, 2012)

abnormal locomotor rhythm, with wdb^EP3559

(Sathyanarayanan et al., 2004)

abnormal locomotor rhythm, with Xlae\csnk1d^D132N.UAS

(Fan et al., 2009)

abnormal locomotor rhythm, with Xlae\csnk1d^S.UAS

(Fan et al., 2009)

abnormal locomotor rhythm, with Xlae\csnk1d^Tau.UAS

(Fan et al., 2009)

abnormal locomotor rhythm, with Xlae\csnk1d^WT.UAS

(Fan et al., 2009)

abnormal locomotor rhythm | adult stage, with Ada2b^NIG.9638R

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with e(y)2^KK102036

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}

(Chen et al., 2014)

abnormal locomotor rhythm | adult stage, with Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}, Scer\GAL80^Pdf.PS

(Chen et al., 2014)

abnormal locomotor rhythm | adult stage, with jet^JF01506

(Lamba et al., 2014)

abnormal locomotor rhythm | adult stage, with Lsm12a^HMS01143

(Lee et al., 2017)

abnormal locomotor rhythm | adult stage, with Lsm12a^KK109445

(Lee et al., 2017)

abnormal locomotor rhythm | adult stage, with me31B^HM05052

(Lee et al., 2017)

abnormal locomotor rhythm | adult stage, with me31B^NIG.4916R

(Lee et al., 2017)

abnormal locomotor rhythm | adult stage, with mir-276a^UAS.pLUC

(Chen and Rosbash, 2016)

abnormal locomotor rhythm | adult stage, with Nipped-A^GD9847

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with Nipped-A^GD15595

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with Nipped-A^NIG.2905R

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with pn^HMC06185

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with PRL-1^HMS01826

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with Scer\GAL80^Pdf.PS, pn^HMC06185

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with Scer\GAL80^Pdf.PS, TFAM^JF02307

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with Scer\GAL80^Pdf.PS, TFAM^UAS.cCa

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with Srrm1^GL00538, Srrm1^KK108396

(Beckwith et al., 2017)

abnormal locomotor rhythm | adult stage, with Srrm1^KK108396

(Beckwith et al., 2017)

abnormal locomotor rhythm | adult stage, with TFAM^JF02307

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with TFAM^UAS.cCa

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage, with Tip60^NIG.6121R

(Mahesh et al., 2020)

abnormal locomotor rhythm | adult stage, with Xvas\XhoI^{UASp.Tag:Mito(kdn),Tag:MYC}

(Chen et al., 2019)

abnormal locomotor rhythm | adult stage | adult stage, with Pink1^dsRNA.UAS

(Julienne et al., 2017)

abnormal locomotor rhythm | female, with fbl^GD10556

(Pandey et al., 2013)

abnormal locomotor rhythm | female, with fbl^KK109160

(Pandey et al., 2013)

abnormal mating, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Kadener et al., 2006)

abnormal neuroanatomy | adult stage, with dom^HMC04451

(Liu et al., 2019)

abnormal neuroanatomy | adult stage, with dom^JF01502

(Liu et al., 2019)

abnormal neuroanatomy | adult stage, with Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}, Scer\GAL80^repo.PL

(Chen et al., 2014)

abnormal neurophysiology | adult stage, with qsm^GD4817

(Buhl et al., 2016)

abnormal oxidative stress response, with fbl^GD10556

(Pandey et al., 2013)

abnormal phototaxis, with Bmul\αBgtx^{UAS.t.Tag:MYC}

(Keene et al., 2011)

abnormal phototaxis, with Hsap\KCNJ2^UAS.EGFP

(Keene et al., 2011)

abnormal phototaxis, with Hsap\KCNJ2^UAS.EGFP, Scer\GAL80^cry.PS

(Keene et al., 2011)

abnormal phototaxis, with Hsap\KCNJ2^UAS.EGFP, Scer\GAL80^Pdf.PS

(Keene et al., 2011)

abnormal sleep, with Hsap\NRXN1^{I1135V.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal sleep, with Hsap\NRXN1^{L893V.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal sleep, with Hsap\NRXN1^{WT.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal sleep, with Hsap\NRXN1^{Y282H.UAS.Tag:FLAG}

(Liu et al., 2021)

abnormal sleep | adult stage, with cac^KK101478

(Hidalgo et al., 2021)

abnormal temperature response | adult stage, with Dh31-R^GD3782

(Goda et al., 2018)

abnormal temperature response | adult stage, with Dh31-R^NIG.17043R

(Goda et al., 2018)

abnormal visual behavior, with fbl^GD10556

(Pandey et al., 2013)

chemical sensitive, with slo^UAS.cGa

(Ghezzi et al., 2013)

decreased cell number | adult stage, with dom^HMC04451

(Liu et al., 2019)

decreased cell number | adult stage, with dom^JF01502

(Liu et al., 2019)

decreased sleep, with mir-276b^UAS.pLUC

(Zhang et al., 2021)

increased cell death | progressive, with dco^{K38R.UAS.Tag:MYC}

(Means et al., 2015)

increased cell death | progressive, with spag^{dsRNA.UAS.cUa}

(Means et al., 2015)

lethal, with Alas^KK101189

(Mandilaras and Missirlis, 2012)

lethal, with CG17683^KK115708

(Mandilaras and Missirlis, 2012)

lethal, with Coprox^KK101688

(Mandilaras and Missirlis, 2012)

lethal, with Cul3^NIG.11861R

(Grima et al., 2012)

lethal, with Eip75B^GD1434

(Mandilaras and Missirlis, 2012)

lethal, with Fer1HCH^GD4853

(Mandilaras and Missirlis, 2012)

lethal, with Fer1HCH^KK110669

(Mandilaras and Missirlis, 2012)

lethal, with galla-1^KK101219

(Mandilaras and Missirlis, 2012)

lethal, with IscU^GD14694

(Marelja et al., 2018, Mandilaras and Missirlis, 2012)

lethal, with Pbgs^GD12588

(Mandilaras and Missirlis, 2012)

lethal, with Ppox^GD11772

(Mandilaras and Missirlis, 2012)

lethal, with tws^UAS.cGa

(Sathyanarayanan et al., 2004)

lethal, with Usp8^DN.UAS

(Luo et al., 2012)

lethal, with Usp8^dsRNA.2.UAS

(Luo et al., 2012)

lethal - all die during embryonic stage, with hid^UAS.cZa

(Stoleru et al., 2004)

long lived, with Ldh^HMS00039

(Long et al., 2020)

partially lethal, with na^E.UAS

(Lear et al., 2005)

partially lethal - majority die, with Sem1^JF02893

(Mahesh et al., 2020)

short lived, with fbl^GD10556

(Pandey et al., 2013)

short lived, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Kadener et al., 2006)

short lived, with Ldh^{UAS.ORF.GW.Tag:HA}

(Long et al., 2020)

short lived, with Scer\GAL80^cry.PS, Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

short lived, with Shaw^{RA.UAS.Tag:FLAG}

(Hodge and Stanewsky, 2008)

short lived | conditional, with mir-210^UAS.cUa

(Niu et al., 2019)

short lived | conditional, with Scer\GAL80^Pdf.PS, mir-210^UAS.cUa

(Niu et al., 2019)

some die during embryonic stage, with hid^UAS.cZa

(Stoleru et al., 2004)

viable, with dco^{K38R.UAS.Tag:MYC}

(Muskus et al., 2007)

viable, with lark^UAS.Tag:HA

(Schroeder et al., 2003)

viable, with Xlae\csnk1d^WT.UAS

(Fan et al., 2009)

Phenotype Manifest In

adult head, with Xvas\XhoI^{UASp.Tag:Mito(kdn),Tag:MYC}

(Chen et al., 2019)

head, with dco^{K38R.UAS.Tag:MYC}

(Means et al., 2015)

head, with spag^{dsRNA.UAS.cUa}

(Means et al., 2015)

larval s-LNv neuron, with dom^JF01502

(Liu et al., 2019)

l-LNv neuron, with Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}, Scer\GAL80^repo.PL

(Chen et al., 2014)

l-LNv neuron | adult stage, with dom^HMC04451

(Liu et al., 2019)

l-LNv neuron | adult stage, with dom^JF01502

(Liu et al., 2019)

l-LNv neuron | adult stage, with qsm^GD4817

(Buhl et al., 2016)

LNv neuron, with Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Kadener et al., 2006)

mitochondrion | adult stage, with Xvas\XhoI^{UASp.Tag:Mito(kdn),Tag:MYC}

(Chen et al., 2019)

pupal s-LNv neuron, with dom^JF01502

(Liu et al., 2019)

s-LNv neuron | adult stage, with dom^HMC04451

(Liu et al., 2019)

s-LNv neuron | adult stage, with dom^JF01502

(Liu et al., 2019)

s-LNv Pdf neuron, with Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}, Scer\GAL80^repo.PL

(Chen et al., 2014)

Detailed Description

Statement

Reference

Blocking clock function (using cyc^{Δ.UAS.Tag:MYC} or tim^UAS.cUa) of Scer\GAL4^tim.PE neurons significantly reduces the circadian rhythmicity of adult emergence after transfer to constant darkness, compared to controls; there is also a reduction when Scer\GAL80^phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4^tim.PE neurons, but this is not significant for tim^UAS.cUa.

Slowing down clock function (using dco^{L.UAS.Tag:MYC}) of Scer\GAL4^tim.PE neurons significantly slows down the periodicity of adult emergence after transfer to constant darkness, compared to controls; this also occurs when Scer\GAL80^phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4^tim.PE neurons. Speeding up clock function (using dco^{S.UAS.Tag:MYC}) of Scer\GAL4^tim.PE neurons significantly speeds up the periodicity of adult emergence after transfer to constant darkness, compared to controls; this also occurs, to a lesser extent, when Scer\GAL80^phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4^tim.PE neurons.

(Selcho et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Bdbt^KK102995, Scer\GAL4^tim.PE has abnormal locomotor rhythm phenotype, enhanceable by dco^{K38R.UAS.Tag:MYC}, Scer\GAL4^tim.PE

(Fan et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^tim.PE, qsm^GD4817 has abnormal neurophysiology | adult stage phenotype, suppressible | partially by NKCC^NIG.2509R, Scer\GAL4^tim.PE

(Buhl et al., 2016)

Scer\GAL4^tim.PE, qsm^GD4817 has abnormal neurophysiology | adult stage phenotype, suppressible by Shaw^{RA.UAS.Tag:FLAG}/Scer\GAL4^tim.PE

(Buhl et al., 2016)

Bdbt^KK102995, Scer\GAL4^tim.PE has abnormal locomotor rhythm phenotype, suppressible by dco^{WT.UAS.Tag:MYC}, Scer\GAL4^tim.PE

(Fan et al., 2013)

Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^KK101472 has abnormal locomotor rhythm phenotype, suppressible | partially by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE

(Zhang and Emery, 2013)

Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^HMS00105 has abnormal locomotor rhythm phenotype, suppressible | partially by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE

(Zhang and Emery, 2013)

Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^HMS00105 has abnormal locomotor rhythm phenotype, suppressible | partially by dnc¹

(Zhang and Emery, 2013)

Atx2^KK100423, Scer\GAL4^tim.PE has abnormal circadian behavior phenotype, suppressible by per^UAS.cYa, Scer\GAL4^tim.PE

(Zhang et al., 2013)

Scer\GAL4^tim.PE, sgg^EP1576 has abnormal locomotor rhythm phenotype, suppressible | partially by cry^b

(Stoleru et al., 2007)

5-HT1B^dsRNA.UAS, 5-HT1B^UAS.cYa, Scer\GAL4^tim.PE has abnormal circadian rhythm phenotype, suppressible by cry^b, Scer\GAL4^tim.PE

(Yuan et al., 2005)

Scer\GAL4^tim.PE, cry^UAS.cDa, cry^b has abnormal circadian rhythm phenotype, suppressible by 5-HT1B^dsRNA.UAS, Scer\GAL4^tim.PE

(Yuan et al., 2005)

Scer\GAL4^tim.PE, sgg^UAS.cBa has abnormal circadian rhythm phenotype, suppressible | partially by 5-HT1B^UAS.cYa, Scer\GAL4^tim.PE

(Yuan et al., 2005)

NOT suppressed by

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^KK101472 has abnormal locomotor rhythm phenotype, non-suppressible by Pdf^{UAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE

(Zhang and Emery, 2013)

Enhancer of

Statement

Reference

dco^{K38R.UAS.Tag:MYC}, Scer\GAL4^tim.PE is an enhancer of abnormal locomotor rhythm phenotype of Bdbt^KK102995, Scer\GAL4^tim.PE

(Fan et al., 2013)

per^UAS.cBa, Scer\GAL4^tim.PE, per⁰¹, per[+] is an enhancer of abnormal circadian rhythm phenotype of cwo^PB9

(Richier et al., 2008)

NOT Enhancer of

Statement

Reference

Atx2^KK100423/Scer\GAL4^tim.PE is a non-enhancer of abnormal circadian behavior phenotype of tyf^Δ11

(Zhang et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^tim.PE/Cipc^KK104160 is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of cwo^f05073

(Rivas et al., 2021)

Scer\GAL4^tim.PE/Rh7^UAS.cNa is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Rh7¹, cry^b

(Ni et al., 2017)

NKCC^NIG.2509R, Scer\GAL4^tim.PE is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Scer\GAL4^tim.PE, qsm^GD4817

(Buhl et al., 2016)

Shaw^{RA.UAS.Tag:FLAG}/Scer\GAL4^tim.PE is a suppressor of abnormal neurophysiology | adult stage phenotype of Scer\GAL4^tim.PE, qsm^GD4817

(Buhl et al., 2016)

dco^{WT.UAS.Tag:MYC}, Scer\GAL4^tim.PE is a suppressor of abnormal locomotor rhythm phenotype of Bdbt^KK102995, Scer\GAL4^tim.PE

(Fan et al., 2013)

Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE is a suppressor | partially of abnormal locomotor rhythm phenotype of Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^KK101472

(Zhang and Emery, 2013)

Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE is a suppressor | partially of abnormal locomotor rhythm phenotype of Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^HMS00105

(Zhang and Emery, 2013)

per^UAS.cYa, Scer\GAL4^tim.PE is a suppressor of abnormal circadian behavior phenotype of Atx2^KK100423, Scer\GAL4^tim.PE

(Zhang et al., 2013)

Scer\GAL4^tim.PE/Dple\cry1^UAS.Tag:MYC is a suppressor of abnormal behavior phenotype of cry^b

(Gegear et al., 2010)

Scer\GAL4^tim.PE/Dple\cry2^UAS.Tag:MYC is a suppressor of abnormal behavior phenotype of cry^b

(Gegear et al., 2010)

Dple\cry1^W328F.UAS/Scer\GAL4^tim.PE is a suppressor of abnormal behavior phenotype of cry^b

(Gegear et al., 2010)

cyc^VP16.UAS/Scer\GAL4^tim.PE is a suppressor of abnormal locomotor rhythm phenotype of Clk^ar

(Kadener et al., 2008)

Scer\GAL4^tim.PE/Dple\cry1^UAS.cZa is a suppressor | partially of abnormal circadian behavior phenotype of cry^b

(Zhu et al., 2008)

cry^b, Scer\GAL4^tim.PE is a suppressor of abnormal circadian rhythm phenotype of 5-HT1B^dsRNA.UAS, 5-HT1B^UAS.cYa, Scer\GAL4^tim.PE

(Yuan et al., 2005)

5-HT1B^dsRNA.UAS, Scer\GAL4^tim.PE is a suppressor of abnormal circadian rhythm phenotype of Scer\GAL4^tim.PE, cry^UAS.cDa, cry^b

(Yuan et al., 2005)

5-HT1B^UAS.cYa, Scer\GAL4^tim.PE is a suppressor | partially of abnormal circadian rhythm phenotype of Scer\GAL4^tim.PE, sgg^UAS.cBa

(Yuan et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^tim.PE/na^UAS.cLa is a non-suppressor of abnormal circadian behavior phenotype of unc80^x42

(Lear et al., 2013)

Scer\GAL4^tim.PE/unc79^UAS.Tag:MYC is a non-suppressor of abnormal circadian behavior phenotype of unc80^x42

(Lear et al., 2013)

Scer\GAL4^tim.PE/na^UAS.cLa is a non-suppressor of abnormal circadian behavior phenotype of unc79^x25

(Lear et al., 2013)

Scer\GAL4^tim.PE/unc80^UAS.Tag:HA is a non-suppressor of abnormal circadian behavior phenotype of unc79^x25

(Lear et al., 2013)

Scer\GAL4^tim.PE, unc80^UAS.Tag:HA, na^UAS.cLa is a non-suppressor of abnormal circadian behavior phenotype of unc79^x25

(Lear et al., 2013)

Pdf^{UAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}, Scer\GAL4^tim.PE is a non-suppressor of abnormal locomotor rhythm phenotype of Dcr-2^UAS.cDa, Scer\GAL4^tim.PE, gw^KK101472

(Zhang and Emery, 2013)

Atx2^KK100423/Scer\GAL4^tim.PE is a non-suppressor of abnormal circadian behavior phenotype of tyf^Δ11

(Zhang et al., 2013)

Scer\GAL4^tim.PE/Dple\cry2^W345F.UAS is a non-suppressor of abnormal behavior phenotype of cry^b

(Gegear et al., 2010)

Scer\GAL4^tim.PE/Dple\cry2^UAS.cZa is a non-suppressor of abnormal circadian behavior phenotype of cry^b

(Zhu et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^tim.PE, qsm^GD4817 has l-LNv neuron | adult stage phenotype, suppressible | partially by NKCC^NIG.2509R, Scer\GAL4^tim.PE

(Buhl et al., 2016)

Scer\GAL4^tim.PE, qsm^GD4817 has l-LNv neuron | adult stage phenotype, suppressible by Shaw^{RA.UAS.Tag:FLAG}/Scer\GAL4^tim.PE

(Buhl et al., 2016)

Suppressor of

Statement

Reference

NKCC^NIG.2509R, Scer\GAL4^tim.PE is a suppressor | partially of l-LNv neuron | adult stage phenotype of Scer\GAL4^tim.PE, qsm^GD4817

(Buhl et al., 2016)

Shaw^{RA.UAS.Tag:FLAG}/Scer\GAL4^tim.PE is a suppressor of l-LNv neuron | adult stage phenotype of Scer\GAL4^tim.PE, qsm^GD4817

(Buhl et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^tim.PE/dom^UAS.A rescues dom^HMC04451

(Liu et al., 2019)

dom^UAS.B/Scer\GAL4^tim.PE rescues dom^HMC04203

(Liu et al., 2019)

dom^UAS.B/Scer\GAL4^tim.PE rescues dom^HMC04451

(Liu et al., 2019)

Scer\GAL4^tim.PE/jet^UAS.cKa rescues jet^set

(Lamba et al., 2014)

Scer\GAL4^tim.PE, dco^EY02910 rescues dco^EY02910

(Zheng et al., 2014)

Scer\GAL4^tim.PE/shn^HMS01167 rescues shn⁷⁵⁶

(Beckwith et al., 2013)

Scer\GAL4^tim.PE/Bdbt^UAS.Tag:FLAG rescues Bdbt^KK102995

(Fan et al., 2013)

Scer\GAL4^tim.PE, unc79^f01615 rescues unc79^x25/unc79^f01615

(Lear et al., 2013)

Scer\GAL4^tim.PE/unc80^UAS.Tag:HA rescues unc80^x42

(Lear et al., 2013)

Scer\GAL4^tim.PE/TrpA1^UAS.(B).cKa rescues TrpA1¹

(Lee and Montell, 2013)

Scer\GAL4^tim.PE/TrpA1^UAS.B.Kwon rescues TrpA1¹

(Lee and Montell, 2013)

gw^shRNAres.UAS/Scer\GAL4^tim.PE rescues gw^HMS00105

(Zhang and Emery, 2013)

Scer\GAL4^tim.PE/per^UAS.cYa rescues per⁰¹

(Kaneko et al., 2012)

Scer\GAL4^tim.PE, ctrip^NIG.17735R, ctrip^GS11430 rescues ctrip^NIG.14656R

(Lamaze et al., 2011)

Scer\GAL4^tim.PE/cry^UAS.Tag:MYC rescues cry^b

(Gegear et al., 2010)

Scer\GAL4^tim.PE/cry^W342F.UAS rescues cry^b

(Gegear et al., 2010)

robo1^UAS.Tag:MYC/Scer\GAL4^tim.PE rescues robo1^BG01092

(Berni et al., 2008)

Scer\GAL4^tim.PE/cwo^UAS.cKa rescues cwo^e04207/cwo^f05073

(Kadener et al., 2007)

cry^UAS.cEa/Scer\GAL4^tim.PE rescues cry^b

(Picot et al., 2007)

cry^UAS.cEa, Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS rescues cry^b

(Picot et al., 2007)

Scer\GAL4^tim.PE, cry^UAS.Tag:MYC, Scer\GAL80^Pdf.PS rescues cry^b

(Stoleru et al., 2007)

Scer\GAL4^tim.PE/cry^UAS.Tag:MYC rescues cry^b

(Stoleru et al., 2007)

Scer\GAL4^tim.PE/na^UAS.cLa rescues na^har

(Lear et al., 2005)

Scer\GAL4^tim.PE/cry^UAS.Tag:MYC rescues cry^b

(Busza et al., 2004)

Scer\GAL4^tim.PE/cry^UAS.cDa rescues cry^b

(Dissel et al., 2004)

Scer\GAL4^tim.PE, Phm^UAS.cTA, Scer\GAL4^Kdm2-36Y rescues Phm^k07623/Phm^P(29)

(Taghert et al., 2001)

Scer\GAL4^tim.PE, Scer\GAL4^dimm-929, Phm^UAS.cTA rescues Phm^k07623/Phm^P(29)

(Taghert et al., 2001)

cry^UAS.cEa/Scer\GAL4^tim.PE rescues cry^b

(Emery et al., 2000)

cry^UAS.cEa/Scer\GAL4^tim.PE rescues cry^b

(Emery et al., 2000)

Scer\GAL4^tim.PE/to^UAS.cSBa rescues to¹

(Sarov-Blat et al., 2000)

Partially rescues

Scer\GAL4^tim.PE/Dh31-R^UAS.cGa partially rescues Dh31-R^NIG.17043R

(Goda et al., 2018)

Scer\GAL4^tim.PE/unc79^UAS.Tag:MYC partially rescues unc79^x25

(Lear et al., 2013)

Scer\GAL4^tim.PE/Pdfr^UAS.cMa partially rescues Pdfr³³⁶⁹

(Im and Taghert, 2010)

Scer\GAL4^tim.PE/S6kII^UAS.cRa partially rescues S6kII^ign-Δ58-1

(Akten et al., 2009)

per^UAS.cBa/Scer\GAL4^tim.PE partially rescues per⁰¹

(Rieger et al., 2009)

Scer\GAL4^tim.PE/jet^UAS.cKa partially rescues jet^c

(Koh et al., 2006)

Scer\GAL4^tim.PE/jet^UAS.cKa partially rescues jet^r

(Koh et al., 2006)

Fails to rescue

Scer\GAL4^tim.PE/dom^UAS.A fails to rescue dom^HMC04203

(Liu et al., 2019)

Scer\GAL4^tim.PE/gw^{AA.shRNAres.UAS} fails to rescue gw^HMS00105

(Zhang and Emery, 2013)

dysc^UAS.long/Scer\GAL4^tim.PE fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

Scer\GAL4^tim.PE, inc^f00285 fails to rescue inc^f00285

(Stavropoulos and Young, 2011)

Scer\GAL4^tim.PE/na^E.UAS fails to rescue na^har

(Lear et al., 2005)

Scer\GAL4^tim.PE/cry^Δ5'.UAS.cDa fails to rescue cry^b

(Dissel et al., 2004)

Scer\GAL4^tim.PE/Phm^UAS.cTA fails to rescue Phm^k07623/Phm^P(29)

(Taghert et al., 2001)

Scer\GAL4^tim.PE/Nf1^UAS.cdNa fails to rescue Nf1^P1

(Williams et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

7126

y¹ w^*; P{GAL4-tim.E}62

80976

y¹ w^*; P{GAL4-tim.E}27/CyO; P{EPgy2}dco^EY02910/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

GAL4^tim.PE

Scer\GAL4^tim.PE

TG²⁷

(Kumar et al., 2014)

Name Synonyms

timeless promoter construct of Emery

(Emery et al., 1998)

Secondary FlyBase IDs

References (163)

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