Comment: Assayed at ZT23
Comment: Authors state tim-gal4 is known to express in all clock neurons.
Comment: medium expression
Comment: faint expression
Drives expression in pacemaker neurons at all developmental stages.
Scer\GAL4tim.PE transcript is expressed in the embryonic brain at stage 16 in 100 cells. These cells co-express tim protein.
The larval Pdf negative s-LNv neuron is concluded to have the same projection pattern as the larval PDF-positive s-LNv neurons.
Expression of Scer\GAL4tim.PE is seen in cells near sensilla on the head capsule, thorax and abdomen of the adult. Expression of Scer\GAL4tim.PE in seen within the abdominal portion of the adult midgut. Expression in the mouth is restricted to the posterior region.
Blocking clock function (using cycΔ.UAS.Tag:MYC or timUAS.cUa) of Scer\GAL4tim.PE neurons significantly reduces the circadian rhythmicity of adult emergence after transfer to constant darkness, compared to controls; there is also a reduction when Scer\GAL80phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4tim.PE neurons, but this is not significant for timUAS.cUa.
Slowing down clock function (using dcoL.UAS.Tag:MYC) of Scer\GAL4tim.PE neurons significantly slows down the periodicity of adult emergence after transfer to constant darkness, compared to controls; this also occurs when Scer\GAL80phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4tim.PE neurons. Speeding up clock function (using dcoS.UAS.Tag:MYC) of Scer\GAL4tim.PE neurons significantly speeds up the periodicity of adult emergence after transfer to constant darkness, compared to controls; this also occurs, to a lesser extent, when Scer\GAL80phm.1.2 is present to restrict expression to a smaller subset of Scer\GAL4tim.PE neurons.
BdbtKK102995, Scer\GAL4tim.PE has locomotor rhythm defective phenotype, enhanceable by dcoK38R.UAS.Tag:MYC, Scer\GAL4tim.PE
Scer\GAL4tim.PE, qsmGD4817 has neurophysiology defective | adult stage phenotype, suppressible | partially by NKCCNIG.2509R, Scer\GAL4tim.PE
Scer\GAL4tim.PE, qsmGD4817 has neurophysiology defective | adult stage phenotype, suppressible by ShawRA.UAS.Tag:FLAG/Scer\GAL4tim.PE
BdbtKK102995, Scer\GAL4tim.PE has locomotor rhythm defective phenotype, suppressible by dcoWT.UAS.Tag:MYC, Scer\GAL4tim.PE
Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwKK101472 has locomotor rhythm defective phenotype, suppressible | partially by PdfUAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE
Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwHMS00105 has locomotor rhythm defective phenotype, suppressible | partially by PdfUAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE
Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwHMS00105 has locomotor rhythm defective phenotype, suppressible | partially by dnc1
Atx2KK100423, Scer\GAL4tim.PE has circadian behavior defective phenotype, suppressible by perUAS.cYa, Scer\GAL4tim.PE
Scer\GAL4tim.PE, sggEP1576 has locomotor rhythm defective phenotype, suppressible | partially by cryb
5-HT1BdsRNA.UAS, 5-HT1BUAS.cYa, Scer\GAL4tim.PE has circadian rhythm defective phenotype, suppressible by cryb, Scer\GAL4tim.PE
Scer\GAL4tim.PE, cryUAS.cDa, cryb has circadian rhythm defective phenotype, suppressible by 5-HT1BdsRNA.UAS, Scer\GAL4tim.PE
Scer\GAL4tim.PE, sggUAS.cBa has circadian rhythm defective phenotype, suppressible | partially by 5-HT1BUAS.cYa, Scer\GAL4tim.PE
Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwKK101472 has locomotor rhythm defective phenotype, non-suppressible by PdfUAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE
dcoK38R.UAS.Tag:MYC, Scer\GAL4tim.PE is an enhancer of locomotor rhythm defective phenotype of BdbtKK102995, Scer\GAL4tim.PE
perUAS.cBa, Scer\GAL4tim.PE, per01, per[+] is an enhancer of circadian rhythm defective phenotype of cwoPB9
Atx2KK100423/Scer\GAL4tim.PE is a non-enhancer of circadian behavior defective phenotype of tyfΔ11
Scer\GAL4tim.PE/Rh7UAS.cNa is a suppressor | partially of circadian rhythm defective | adult stage phenotype of Rh71, cryb
NKCCNIG.2509R, Scer\GAL4tim.PE is a suppressor | partially of neurophysiology defective | adult stage phenotype of Scer\GAL4tim.PE, qsmGD4817
ShawRA.UAS.Tag:FLAG/Scer\GAL4tim.PE is a suppressor of neurophysiology defective | adult stage phenotype of Scer\GAL4tim.PE, qsmGD4817
dcoWT.UAS.Tag:MYC, Scer\GAL4tim.PE is a suppressor of locomotor rhythm defective phenotype of BdbtKK102995, Scer\GAL4tim.PE
PdfUAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE is a suppressor | partially of locomotor rhythm defective phenotype of Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwKK101472
PdfUAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE is a suppressor | partially of locomotor rhythm defective phenotype of Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwHMS00105
perUAS.cYa, Scer\GAL4tim.PE is a suppressor of circadian behavior defective phenotype of Atx2KK100423, Scer\GAL4tim.PE
Scer\GAL4tim.PE/Dple\cry1UAS.Tag:MYC is a suppressor of behavior defective phenotype of cryb
Scer\GAL4tim.PE/Dple\cry2UAS.Tag:MYC is a suppressor of behavior defective phenotype of cryb
Dple\cry1W328F.UAS/Scer\GAL4tim.PE is a suppressor of behavior defective phenotype of cryb
cycVP16.UAS/Scer\GAL4tim.PE is a suppressor of locomotor rhythm defective phenotype of Clkar
Scer\GAL4tim.PE/Dple\cry1UAS.cZa is a suppressor | partially of circadian behavior defective phenotype of cryb
cryb, Scer\GAL4tim.PE is a suppressor of circadian rhythm defective phenotype of 5-HT1BdsRNA.UAS, 5-HT1BUAS.cYa, Scer\GAL4tim.PE
5-HT1BdsRNA.UAS, Scer\GAL4tim.PE is a suppressor of circadian rhythm defective phenotype of Scer\GAL4tim.PE, cryUAS.cDa, cryb
5-HT1BUAS.cYa, Scer\GAL4tim.PE is a suppressor | partially of circadian rhythm defective phenotype of Scer\GAL4tim.PE, sggUAS.cBa
Scer\GAL4tim.PE/naUAS.cLa is a non-suppressor of circadian behavior defective phenotype of unc80x42
Scer\GAL4tim.PE/unc79UAS.Tag:MYC is a non-suppressor of circadian behavior defective phenotype of unc80x42
Scer\GAL4tim.PE/naUAS.cLa is a non-suppressor of circadian behavior defective phenotype of unc79x25
Scer\GAL4tim.PE/unc80UAS.Tag:HA is a non-suppressor of circadian behavior defective phenotype of unc79x25
Scer\GAL4tim.PE, unc80UAS.Tag:HA, naUAS.cLa is a non-suppressor of circadian behavior defective phenotype of unc79x25
PdfUAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1), Scer\GAL4tim.PE is a non-suppressor of locomotor rhythm defective phenotype of Dcr-2UAS.cDa, Scer\GAL4tim.PE, gwKK101472
Atx2KK100423/Scer\GAL4tim.PE is a non-suppressor of circadian behavior defective phenotype of tyfΔ11
Scer\GAL4tim.PE/Dple\cry2W345F.UAS is a non-suppressor of behavior defective phenotype of cryb
Scer\GAL4tim.PE/Dple\cry2UAS.cZa is a non-suppressor of circadian behavior defective phenotype of cryb
Scer\GAL4tim.PE, qsmGD4817 has l-LNv neuron | adult stage phenotype, suppressible | partially by NKCCNIG.2509R, Scer\GAL4tim.PE
Scer\GAL4tim.PE, qsmGD4817 has l-LNv neuron | adult stage phenotype, suppressible by ShawRA.UAS.Tag:FLAG/Scer\GAL4tim.PE
NKCCNIG.2509R, Scer\GAL4tim.PE is a suppressor | partially of l-LNv neuron | adult stage phenotype of Scer\GAL4tim.PE, qsmGD4817
ShawRA.UAS.Tag:FLAG/Scer\GAL4tim.PE is a suppressor of l-LNv neuron | adult stage phenotype of Scer\GAL4tim.PE, qsmGD4817
cryUAS.cEa/Scer\GAL4tim.PE rescues cryb
Scer\GAL4tim.PE/naUAS.cLa rescues nahar
Scer\GAL4tim.PE/cryUAS.cDa rescues cryb
cryUAS.cEa/Scer\GAL4tim.PE rescues cryb
cryUAS.cEa/Scer\GAL4tim.PE rescues cryb
Scer\GAL4tim.PE/Dh31-RUAS.cGa partially rescues Dh31-RNIG.17043R
Scer\GAL4tim.PE/unc79UAS.Tag:MYC partially rescues unc79x25
Scer\GAL4tim.PE/PdfrUAS.cMa partially rescues Pdfr3369
Scer\GAL4tim.PE/S6kIIUAS.cRa partially rescues S6kIIign-Δ58-1
perUAS.cBa/Scer\GAL4tim.PE partially rescues per01
Scer\GAL4tim.PE/jetUAS.cKa partially rescues jetc
Scer\GAL4tim.PE/jetUAS.cKa partially rescues jetr
Scer\GAL4tim.PE/domUAS.A fails to rescue domHMC04203
Scer\GAL4tim.PE/gwAA.shRNAres.UAS fails to rescue gwHMS00105
dyscUAS.long/Scer\GAL4tim.PE fails to rescue dyscs168/dyscc03838
Scer\GAL4tim.PE, incf00285 fails to rescue incf00285
Scer\GAL4tim.PE/naE.UAS fails to rescue nahar
Scer\GAL4tim.PE/cryΔ5'.UAS.cDa fails to rescue cryb
Scer\GAL4tim.PE/PhmUAS.cTA fails to rescue Phmk07623/PhmP(29)
Scer\GAL4tim.PE/Nf1UAS.cdNa fails to rescue Nf1P1