Allele Dmel\CycB²

General Information
Symbol	Dmel\CycB²	Species	D. melanogaster
Name		FlyBase ID	FBal0094855
Feature type	allele	Associated gene	Dmel\CycB

Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Jacobs et al., 1998)
Mutagen	Delta2-3 (Jacobs et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	CycB¹ (Jacobs et al., 1998)
Nature of the lesion	Statement Reference Imprecise excision of P-element resulting in small deletion removing the region encoding α-helix 1, a conserved element of the cyclin box. (Jacobs et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	cytokinesis defective (Echard and O'Farrell, 2003) female sterile (Jacobs et al., 1998) male sterile (Jacobs et al., 1998) mitotic cell cycle defective (Echard and O'Farrell, 2003) viable (Jacobs et al., 1998)
Phenotype Manifest In
	embryonic abdominal segment (with CycB³), with CycB^2xNRE.hb (Kadyrova et al., 2007) female germline cell (Chau et al., 2009) filzkorper (with CycB³), with CycB^2xNRE.hb (Kadyrova et al., 2007) ovary (Jacobs et al., 1998)
Detailed Description
	Statement Reference Mutant ovaries contain few or no germ cells. (Chau et al., 2009) Over 95% of embryos derived from CycB²/CycB³ ; CycB^2xNRE.hb females have defects in the abdominal segments, the posterior terminalia, or both. In extreme cases, the embryos die with an open posterior hole and not segments following the third thoracic one. The defects appear to arise during nuclear cleavage cycles 9-13; the somatic nuclei in the posterior of the embryos delay progression through cycles 9-13 and ultimately lose contact with the embryonic cortex, falling into the interior. (Kadyrova et al., 2007) Mutant embryos appear to start cytokinesis earlier than wild-type embryos. These embryos also appear to stay in cytokinesis longer than normal. (Echard and O'Farrell, 2003) Mutant females have rudimentary ovaries and lay few eggs. Homozygotes and hemizygotes reach adulthood. (Jacobs et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference CycB[+]/CycB² is an enhancer of mitotic cell cycle defective \| maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸ (Lee et al., 2001) CycB² is an enhancer of visible phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
NOT Enhancer of
Statement Reference CycB² is a non-enhancer of visible phenotype of os^GMR.PB (Mukherjee et al., 2006)
Suppressor of
Statement Reference CycB[+], CycB3^L6540, CycB², CycB3[+] is a suppressor \| partially of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.Scer\UAS} (Gregory et al., 2007) CycB[+]/CycB² is a suppressor \| maternal effect \| partially of mitotic cell cycle defective \| maternal effect \| embryonic cycle 14 phenotype of Df(3L)Cat/Capr², Fmr1³/Fmr1[+] (Papoulas et al., 2010) CycB[+]/CycB² is a suppressor \| partially of mitotic cell cycle defective \| maternal effect \| embryonic stage phenotype of Scer\GAL4^αTub84B.PL, Xpd^SH2137, Xpd^{Scer\UAS.T:SV5\V5} (Li et al., 2010) CycB[+]/CycB² is a suppressor \| partially of visible phenotype of E(mus304)[+]/DNApol-α180^Emus304, mei-41^29D (LaRocque et al., 2007) CycB[+]/CycB² is a suppressor of visible phenotype of Scer\GAL4^en-e16E, crol^Scer\UAS.cMa (Mitchell et al., 2008)
NOT Suppressor of
Statement Reference CycB² is a non-suppressor of visible phenotype of os^GMR.PB (Mukherjee et al., 2006)
Other
Statement Reference CycB3², CycB² has lethal phenotype (Jacobs et al., 1998, Jacobs et al., 1998) CycB3³, CycB² has lethal phenotype (Jacobs et al., 1998, Jacobs et al., 1998) CycB3^L6540, CycB² has lethal phenotype (Jacobs et al., 1998) CycB[+]/CycB², CycD¹ has viable phenotype (Emmerich et al., 2004) CycB[+]/CycB², CycD² has viable \| reduced phenotype (Emmerich et al., 2004) CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye color defective \| dominant phenotype (Schneiderman et al., 2010) CycB², CycD¹ has viable phenotype (Emmerich et al., 2004) CycB², CycD² has viable \| reduced phenotype (Emmerich et al., 2004)
Phenotype Manifest In
Enhancer of
Statement Reference CycB² is an enhancer of cardioblast phenotype of CycA^C8LR1 (Han and Bodmer, 2003) CycB² is an enhancer of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005) CycB² is an enhancer of mitotic cell cycle phenotype of CycA^C8LR1 (Han and Bodmer, 2003)
NOT Enhancer of
Statement Reference CycB² is a non-enhancer of eye phenotype of os^GMR.PB (Mukherjee et al., 2006) CycB² is a non-enhancer of phenotype of Myb^unspecified (Fung et al., 2003)
Suppressor of
Statement Reference CycB[+], CycB3^L6540, CycB², CycB3[+] is a suppressor \| partially of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.Scer\UAS} (Gregory et al., 2007) CycB[+]/CycB² is a suppressor \| partially of eye phenotype of E(mus304)[+]/DNApol-α180^Emus304, mei-41^29D (LaRocque et al., 2007) CycB[+]/CycB² is a suppressor of wing \| posterior compartment phenotype of Scer\GAL4^en-e16E, crol^Scer\UAS.cMa (Mitchell et al., 2008)
NOT Suppressor of
Statement Reference CycB² is a non-suppressor of eye phenotype of os^GMR.PB (Mukherjee et al., 2006) CycB² is a non-suppressor of phenotype of Myb^unspecified (Fung et al., 2003)
Other
Statement Reference CycB3³, CycB² has cycle 15 embryo phenotype (Jacobs et al., 1998, Jacobs et al., 1998) CycB3^L6540, CycB² has cycle 15 embryo phenotype (Jacobs et al., 1998, Jacobs et al., 1998) CycB3^L6540, CycB² has spindle phenotype (Jacobs et al., 1998) CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference The nuclear division defects seen in embryos derived from homozygous Xpd[SH2137] females expressing Xpd[Scer\UAS.T:SV5\V5] under the control of Scer\GAL4[αTub84B.PL] are partially rescued if the females are carrying CycB[2]/+. (Li et al., 2010) Reduction of maternal CycB by one half (using the CycB[2] allele) in the Capr[2]/Df(3L)Cat, Fmr1[3]/+ background partially rescues the premature mitosis 14 phenotype seen in embryos of this genotype. (Reduction of the zygotic contribution of CycB has no effect.) (Papoulas et al., 2010) snf[148] ; CycB[2] double mutant ovaries are not tumourous and contain few or no germ cells, similar to the CycB[2] single mutant phenotype. (Chau et al., 2009) The reduced size of the posterior compartment of the wing that is seen in animals expressing crol[Scer\UAS.cMa] under the control of Scer\GAL4[en-e16E] is suppressed if they are also heterozygous for CycB[2]. (Mitchell et al., 2008) The rough eye phenotype seen in mei-41^29D ; DNApol-α180^Emus304/+ adults is partially rescued by CycB²/+. (LaRocque et al., 2007) The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is partly suppressed by CycB²/+. The lethality seen in mei-41^29D males in which excision of an insertion of P{hsw^a} is induced during development is completely suppressed if the female parent carries CycA^C8LR1 and if the male progeny carries both CycA^C8LR1 and CycB². (LaRocque et al., 2007) Adult viability of CycD²/Y ; CycB²/+ males is 90% of expected value. (Emmerich et al., 2004) The addition of CycB² has no effect on Myb^unspecified viability. (Fung et al., 2003) CycA^C8LR1, CycB² double mutants arrest mesodermal division at mitosis 15 a more severe phenotype than CycA^C8LR1 alone. Also a further reduction in the number of myocardial cells is seen. (Han and Bodmer, 2003) CycB3^L6540 CycB^- (CycB² or Df(2R)599-5) double mutants have defective late mitotic figures during mitosis 15 and multipolar spindles at stage 13. (Jacobs et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	CycB² is rescued by CycB^+t10 (Jacobs et al., 1998)
Comments
Stocks ( 1 )
Bloomington	6630 w^*; CycB²/CyO, P{ftz/lacB}E3
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	2 (Mukherjee et al., 2006) cycB² (Lee et al., 2001, Gregory et al., 2007, Li et al., 2010, Schneiderman et al., 2010) CycB² (LaRocque et al., 2007, LaRocque et al., 2007, Kadyrova et al., 2007, Christensen et al., 2008.9.3, Chau et al., 2009, Mitchell et al., 2008, Althoff et al., 2009, Glavic et al., 2009, Papoulas et al., 2010) cyclin B² (Fung et al., 2003)
Name Synonym
Secondary FlyBase IDs

References ( 24 )

Generate a list of	All references relating to this allele ( 24 )

List References by type	Research paper ( 23 ) Personal communication to FlyBase ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\CycB2

Allele Dmel\CycB²