Allele Dmel\shot^HG25

General Information
Symbol	Dmel\shot^HG25	Species	D. melanogaster
Name		FlyBase ID	FBal0095203
Feature type	allele	Associated gene	Dmel\shot

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Prokop et al., 1998) neuroanatomy defective \| embryonic stage (with shot^91k) (Prokop et al., 1998) paralytic \| recessive (Prokop et al., 1998)
Phenotype Manifest In
	embryonic/first instar larval cuticle (Prokop et al., 1998) embryonic/larval somatic muscle (Prokop et al., 1998) muscle attachment site \| embryonic stage (Prokop et al., 1998) neuromuscular junction \| embryonic stage (Prokop et al., 1998) synapse & neuromuscular junction (Lohr et al., 2002)
Detailed Description
	Statement Reference shot^HG25 mutants show strong reduction of output synapses at the NMJ, while this phenotype is not seen in the CNS. (Lohr et al., 2002) Homozygous and hemizygous embryos show a paralytic phenotype. Neuromuscular junctions occupy far less surface of their respective muscles, their branches are reduced in length and boutons appear reduced in number and size in hemizygous and shot^HG25/shot^91k embryos compared to wild-type. Peripheral nerves can form correctly in shot^91k/shot^HG25 embryos. The short SNb-branch has a tendency to stall in these embryos. shot^91k/shot^HG25 embryos do not show any obvious defects in muscle patterning at stage 16. However, at stage 17, severe detachment of the muscles from the cuticle is seen, although the muscles remain attached to each other. (Prokop et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	shot^91k (Prokop et al., 1998) shot^el3 (Prokop et al., 1998) shot^k03405 (Prokop et al., 1998) shot^SF20 (Prokop et al., 1998) shot^V168 (Prokop et al., 1998)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: wb allele in screen over wb^SF20. (Prokop et al., 1998)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	kak^HG25 (Lohr et al., 2002, ) shot^HG25
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Lohr et al., 2002, J. Neurosci. 22(23): 10357--10367 Compartmentalization of central neurons in Drosophila: a new strategy of mosaic analysis reveals localization of presynaptic sites to specific segments of neurites. [FBrf0152141] Prokop et al., 1998, J. Cell Biol. 143(5): 1283--1294 The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motorneurons. [FBrf0105910]

Allele Dmel\shotHG25

Allele Dmel\shot^HG25