Nucleotide substitution: G?A.
The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal30 amino acids of the wild-type product.
Amino acid replacement: W1378term.
G11392006A
G?A
W1645term | pros-PH; W1806term | pros-PI; W1374term | pros-PJ; W1506term | pros-PK; W1345term | pros-PL; W1674term | pros-PM
W1378term
G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.
Anterior and posterior commissures fail to separate and longitudinal connectives do not form. Axon pathfinding from the sensory organs in the PNS is abnormal, so the sensilla fail to innervate the CNS.
Induced with: RpII140S8.