Allele Dmel\Hem^unspecified

General Information
Symbol	Dmel\Hem^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0095346
Feature type	allele	Associated gene	Dmel\Hem

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	commissure (Hummel et al., 1999, Hummel et al., 1999) cytoskeleton (Hummel et al., 2000) cytoskeleton & ectoderm (Hummel et al., 2000) cytoskeleton & embryonic central nervous system (Hummel et al., 2000) cytoskeleton & mesoderm (Hummel et al., 2000) embryonic/larval midgut \| embryonic stage (Hummel et al., 2000) embryonic/larval somatic muscle (Hummel et al., 2000) interface glial cell (Hummel et al., 2000) longitudinal connective (Hummel et al., 1999) midline glial cell (Hummel et al., 1999) motor neuron (Hummel et al., 1999) presumptive embryonic/larval central nervous system (Hummel et al., 1999) presumptive embryonic/larval peripheral nervous system (Hummel et al., 1999) sensory neuron (Hummel et al., 1999) sensory neuron \| embryonic stage (Hummel et al., 2000) ventral midline & neuron (Hummel et al., 2000) VUM neuron (Hummel et al., 2000)
Detailed Description
	Statement Reference The VUM axons project abnormally in mutant embryos. Variable defects in the projection pattern can be seen in every neuromere. In approximately 20% of embryos, the VUM axons project normally to the posterior commissure but do not follow the correct path once they have reached the anterior commissure. In approximately 30% of embryos, severe VUM projection defects are seen from early stages onward. In the remaining embryos, the projection defects are such that the VUM axons cannot be discriminated from other neuronal processes. The number of midline neurons is normal in mutant embryos, but their position is slightly altered. Longitudinal connectives do not form properly in mutant embryos and axons are occasionally seen to cross the midline. Defects can be seen during early stages of axonal outgrowth. No gross alterations are seen in the number or fate of cortical neurons. The longitudinal glial cells are present in their normal number but are displaced and concentrated at the commissures. A slight reduction in the number of all sensory neurons and changes in their cellular morphology is seen in the peripheral nervous system of mutant embryos. The size of the segmental nerves is reduced, however the axonal projections toward the ventral nerve cord appear normal. A severe reduction in the number of muscle fibres is seen in mutant embryos. In addition midgut formation is affected. The organisation of the F-actin cytoskeleton is abnormal in mutant embryos. The regular appearance of the cytoskeleton is disrupted in both mesoderm and ectoderm. (Hummel et al., 2000) Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons. (Hummel et al., 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference Hem^unspecified is an enhancer of macrochaeta phenotype of Scer\GAL4^sca.PC, Sra-1^{dsRNA.Scer\UAS} (Bogdan et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The penetrance of the bent macrochaeta phenotype seen in the heads of Sra-1^{dsRNA.Scer\UAS}; Scer\GAL4^sca.PC flies is enhanced by Hem^unspecified/+. (Bogdan et al., 2004) Commissures fail to develop in most neuromeres of Hem^unspecified pnt^unspecified double mutant embryos. (Hummel et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Not rescued by	Hem^unspecified is not rescued by Hem^Scer\UAS.cHa/Scer\GAL4^sli.PS (Hummel et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Hem^unspecified kte^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Bogdan et al., 2004, Development 131(16): 3981--3989 Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. [FBrf0179141] Hummel et al., 2000, Genes Dev. 14(7): 863--873 The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization. [FBrf0127130] Hummel et al., 1999, Development 126(4): 771--779 Commissure formation in the embryonic CNS of Drosophila. [FBrf0106675] Hummel et al., 1999, Dev. Biol. 209(2): 381--398 Commissure formation in the embryonic CNS of Drosophila. [FBrf0108204]

Allele Dmel\Hemunspecified

Allele Dmel\Hem^unspecified