Open Close
General Information
Symbol
Hsap\APP695SPA4CT.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0095693
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A mutant form of Hsap\APP which lacks the extracellular domain (but contains the signal peptide, βA4 region and cytoplasmic tail) tagged at the C-terminus with Tag:MYC is expressed under the control of UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC in the adult mushroom bodies under the control of Scer\GAL4Mef2.247.Switch exhibit a long-term memory defect.

Expression of Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC, under the control of Scer\GAL4P2.4.Pdf, results in increased axonal arborization of the sLNv.

When Hsap\APP695-Swedish.Scer\UAS is driven by Scer\GAL4Appl.G1a or Scer\GAL4179Y an occasional accumulation of organelles is seen in larval axons (about 10 clogs per 50μm). When Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4Appl.G1a, apoptosis is seen in the larval brain.

Flies expressing Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mz1087.hx do not have a wing blister phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The organelle clogging phenotype seen in mutant larvae (Driven by Scer\GAL4Appl.G1a) is suppressed by the addition of Df(3L)GN24. The organelle clogging phenotype seen in mutant larvae (Driven by Scer\GAL4Appl.G1a) is suppressed by the addition of roblK/+. The apoptosis phenotype seen in Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC, Scer\GAL4Appl.G1a animals is enhanced by the addition of Khc8 or Klc8ex94. The apoptosis phenotype seen in Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC, Scer\GAL4Appl.G1a animals is enhanced by the addition of roblK or Df(3L)GN24.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Carried in a plasmid and transfected into SL-2 cells with a Scer\GAL4 expression plasmid. The expression and metabolism of Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC protein in these cells has been studied.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC
Hsap\APP695SPA4CT.UAS.T:Myc
Hsap\APP695SPA4CT.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (6)