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General Information
Symbol
Dmel\Egfr1.A887T.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0095743
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-EgfrElp type I
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
Expression of mutant Type 1 Egfr coding region (carries the amino acid replacement A887T) is governed by UASt regulatory sequences.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Over-expression of Egfr1.A887T.Scer\UAS in MARCM mutant clones (under the control of Scer\GAL4esg-NP5130) induces intestinal stem cell proliferation.
Over-expression using Scer\GAL4fkh.PH leads to invagination of salivary gland cells with slightly aberrant shapes and to an invagination hole that is too large. This leads to fully invaginated glands with a too large and aberrantly shaped lumen, although the individual and common ducts appear normal.
Expression of Egfr1.A887T.Scer\UAS under the control of Scer\GAL4dpp.blk1 results in ectopic marginal furrow formation in the eye disc.
When expression is driven by Scer\GAL432B extra vein tissue appears in the wing. When expression is driven by Scer\GAL4h-H10 eyes show gaps in the array of ommatidia.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The reduction in total cell number per clone and reduction in number of Dl-positive intestinal stem cells per clone seen in MARCM clones in the intestine of lin-28Δ1 adults is not rescued by expression of Egfr1.A887T.Scer\UAS under the control of Scer\GAL4tub.PU.
Expression of Egfr1.A887T.Scer\UAS under the control of Scer\GAL4hs.PU partially restores cyst formation in Inx2FA42 females (branched fusomes are observed in 77% of cases), but the formation of egg chambers is not rescued in these females.
Knock-down of yki through co-expression of ykidsRNA.N.Scer\UAS in Egfr1.A887T.Scer\UAS MARCM mutant clones (under the control of Scer\GAL4esg-NP5130) does not affect intestinal stem cell proliferation.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Egfr1.A887T.Scer\UAS
Egfr1.A887T.UAS
Name Synonyms
Secondary FlyBase IDs
    References (8)