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General Information
Symbol
Dmel\AblK417N.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0095896
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-AblK417N, UAS-DAblK417N
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A kinase defective form of Abl is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing AblK417N.UAS under the control of Scer\GAL4GMR.PU induces a very mild rough eye phenotype.

Third instar larvae expressing AblK417N.UAS under the control of Scer\GAL4elav-C155 (but not Scer\GAL4how-24B) display supernumerary mature and satellite NMJ boutons.

Ectopic expression of AblK417N.Scer\UAS under the control of Scer\GAL4ppk.PG does not cause any excessive presynaptic terminal growth and the number of connectives in class IV dendritic arborizing neurons in third instar larvae is the same as in wild-type controls.

Expression of AblK417N.Scer\UAS, under the control of Scer\GAL4P2.4.Pdf, has no effect on LNv morphology.

When AblK417N.Scer\UAS is driven by Scer\GAL4elav.PLu, no significant defects are seen.

Flies expressing AblK417N.Scer\UAS under the control of Scer\GAL4hs.2sev have no detectable eye phenotype.

ISNb bypass phenotypes are not produced when AblK417N.Scer\UAS is expressed under the control of Scer\GAL4elav.PLu.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

AblK417N.UAS, Scer\GAL4elav.PLu has phenotype, non-enhanceable by robo11

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The rough eye phenotype caused by expression of HemScer\UAS.T:Myr-Src64B under the control of Scer\GAL4GMR.PU is suppressed by co-expression of AblK417N.Scer\UAS.

Coexpression of AblK417N.Scer\UAS reduces the efficiency of eyaWT.Scer\UAS to rescue the 'eyeless' phenotype of eya2 from 100% to 40%.

Xenogenetic Interactions
Statement
Reference

Coexpression of AblK417N.Scer\UAS of with Hsap\APPScer\UAS.T:Hsap\MYC in the sLNv (both driven by Scer\GAL4P2.4.Pdf) reduces the extent of sLNv axonal arborization compared to expression of only the Hsap\APPScer\UAS.T:Hsap\MYC transgene.

Complementation and Rescue Data
Partially rescues
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
AblK417N.Scer\UAS
AblK417N.UAS
Name Synonyms
Secondary FlyBase IDs
    References (11)