Allele Dmel\α-Cat^{Scer\UAS.T:Avic\GFP-sg}

General Information
Symbol	Dmel\α-Cat^{Scer\UAS.T:Avic\GFP-sg}	Species	D. melanogaster
Name		FlyBase ID	FBal0095916
Feature type	allele	Associated gene	Dmel\α-Cat

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms cone cell
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Oda and Tsukita, 1999) in vitro construct - regulatory fusion (Oda and Tsukita, 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of full length α-Cat tagged at the carboxyl terminus with T:Avic\GFP. (Oda and Tsukita, 1999)
Carried in construct	P{UAS-α-Cat.T:GFP.sg} (Wang et al., 2006, Kaltschmidt et al., 2002, Oda and Tsukita, 1999, Le Borgne et al., 2002, Woolner et al., 2005, Roch et al., 2003, Simoes et al., 2006, Grieder et al., 2008, Larson et al., 2008, Schock and Perrimon, 2002, Knox and Brown, 2002, Wood et al., 2002, Cordero et al., 2007, Jacinto et al., 2000, Oda and Tsukita, 1999, Ribeiro et al., 2004, Bradley et al., 2003, Jung et al., 2006, Vidal et al., 2006, Chanut-Delalande et al., 2006, Johnson et al., 2011, Caussinus et al., 2008, Shindo et al., 2008, Cabernard and Affolter, 2005, Haghayeghi et al., 2010, Johnson et al., 2008, Gettings et al., 2010, Sekyrova et al., 2010, Kaido et al., 2009, Dottermusch-Heidel et al., 2012, Förster and Luschnig, 2012, Seppa et al., 2008)
Tagged with	T:Avic\GFP^sg (Oda and Tsukita, 1999, Oda and Tsukita, 1999, Jacinto et al., 2000, Le Borgne et al., 2002, Schock and Perrimon, 2002, Knox and Brown, 2002, Wood et al., 2002, Kaltschmidt et al., 2002, Bradley et al., 2003, Roch et al., 2003, Jazwinska et al., 2003, Ribeiro et al., 2004, Woolner et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Larson et al., 2008)
Phenotype Manifest In
	cone cell, with Scer\GAL4^GMR.PF (Seppa et al., 2008)
Detailed Description
	Statement Reference Expression of Scer\GAL4[GMR.PF] driven α-Cat[Scer\UAS.T:Avic\GFP-sg] does not effect patterning of the eye compared to Scer\GAL4[GMR.PF] alone. (Larson et al., 2008) Expression of α-Cat[Scer\UAS.T:Avic\GFP-sg] under the control of Scer\GAL4[GMR.PF] results in low level failure to switch cone-cell contacts. (Seppa et al., 2008) No morphological abnormalities are seen in embryos expressing α-Cat^{Scer\UAS.T:Avic\GFP-sg} under the control of Scer\GAL4^en-e16E. (Oda and Tsukita, 1999) α-Cat^{Scer\UAS.T:Avic\GFP-sg} when driven by Scer\GAL4^btl.PS produces embryos with normal adherens junction patterns. Almost all (98.9%) dorsal trunk fusions are successful. (Oda and Tsukita, 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is an enhancer of neuroanatomy defective phenotype of p120ctn³⁰⁸ (Larson et al., 2008) α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is an enhancer of neuroanatomy defective phenotype of rst⁶ (Larson et al., 2008)
Suppressor of
Statement Reference α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of neuroanatomy defective phenotype of N^fa-g (Larson et al., 2008)
Phenotype Manifest In
Enhancer of
Statement Reference α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Scer\GAL4^GMR.PF is an enhancer of cone cell \| pupal stage phenotype of Scer\GAL4^GMR.PF, pyd^{3.dsRNA.Scer\UAS} (Seppa et al., 2008)
Other
Statement Reference α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Df(2R)E2/shg², Scer\GAL4^btl.PS has embryonic/larval dorsal trunk phenotype (Oda and Tsukita, 1999, Oda and Tsukita, 1999) α-Cat^{Scer\UAS.T:Avic\GFP-sg}, Df(2R)E2/shg², Scer\GAL4^btl.PS has embryonic/larval tracheal system phenotype (Oda and Tsukita, 1999, Oda and Tsukita, 1999)
Additional Comments
Genetic Interactions
Statement Reference Expression of Scer\GAL4[GMR.PF] driven α-Cat[Scer\UAS.T:Avic\GFP-sg] leads to a mild suppression of the N[fa-g] pupal retina phenotypes. Expression of Scer\GAL4[GMR.PF] driven α-Cat[Scer\UAS.T:Avic\GFP-sg] leads to a mild enhancement of some of the rst[6] pupal retina patterning phenotypes. Expression of Scer\GAL4[GMR.PF] driven α-Cat[Scer\UAS.T:Avic\GFP-sg] leads to a mild enhancement of the p120ctn[308] pupal retina patterning error phenotypes. (Larson et al., 2008) Expression of α-Cat[Scer\UAS.T:Avic\GFP-sg] strongly enhances the cone cell switching phenotype seen 41-42 hours after pupal formation when pyd[3.dsRNA.Scer\UAS] is expressed under the control of Scer\GAL4[GMR.PF]. A greater proportion of ommatidia maintain the immature A/P configuration rather than switching to the E/P configuration as is seen in controls. (Seppa et al., 2008) shg²/Df(2R)E2 embryos with α-Cat^{Scer\UAS.T:Avic\GFP-sg} driven by Scer\GAL4^btl.PS, show largely disordered tracheal branching. No successful dorsal trunk fusions are seen in these embryos. The addition of shg^Scer\UAS.cOa to these flies rescues these phenotypes to nearly wild-type. Tracheal patterning is normal, although tracheal branches and connectives in the embryos are less extended than in wild-type. (Oda and Tsukita, 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Kyoto	109001 w^*; P{UAS-α-Cat.T:GFP.sg}3 / CyO
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	α-Cat^{Scer\UAS.T:Avic\GFP} α-Cat^{Scer\UAS.T:Avic\GFP-sg}
Name Synonym
Secondary FlyBase IDs

References ( 33 )

Generate a list of	All references relating to this allele ( 33 )

List References by type	Research paper ( 33 )
Recent research papers ( 3 )
	Dottermusch-Heidel et al., 2012, Dev. Biol. 368(1): 18--27 The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. [FBrf0218661] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Johnson et al., 2011, Mol. Biol. Cell 22(23): 4513--4526 Role for a Cindr-Arf6 axis in patterning emerging epithelia. [FBrf0216708] Show all research papers ...

Allele Dmel\α-CatScer\UAS.T:Avic\GFP-sg

Allele Dmel\α-Cat^{Scer\UAS.T:Avic\GFP-sg}