|Feature type||allele||Associated gene||Dmel\tkv|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Scer\GAL4 driven tkv[CA.Scer\UAS] engenders an approximately two-fold increase in the number of tergal depressor of trochanter (TDT) muscle fibers, although each individual fiber is somewhat smaller than in wild-type muscle. An increase in the number of TDT founder cells is clearly visible by 16 hours after puparium formation (APF) as a result of Scer\GAL4 driven tkv[CA.Scer\UAS] expression.
When tkvCA.Scer\UAS clones are made in the wing disc (driven by Scer\GAL4Act5C.PI) produces clones with a rounded appearance.
Normal wing venation is severely distorted when tkvCA.Scer\UAS is expressed under the control of Scer\GAL471B, and extensive production of fragments of vein material is seen. The abdominal cuticle pattern is irregular. The wing phenotype is significantly suppressed by exposure of the larvae to the imidazole compound SB203580 (a p38 inhibitor). The wing phenotype caused by tkvCA.Scer\UAS expressed under the control of Scer\GAL471B is not suppressed by tkv7.
Flies expressing tkvCA.Scer\UAS under the control of Scer\GAL471B often show notching of the wing margin. The notches are located away from the distal tip of the wing and are limited to the more proximal region. Dying cells are distributed throughout the primordium of the proximal wing in wing discs expressing tkvCA.Scer\UAS under the control of Scer\GAL471B but are absent from the distal wing primordium. When tkvCA.Scer\UAS is expressed mosaically in the wing primordia using Scer\GAL4Act5C.PI, dying cells are seen in clones in the proximal wing but not in the distal wing.
|Phenotype Manifest In|
|NOT suppressed by|
tkvCA.Scer\UAS/Scer\GAL4hs.2sev is an enhancer of ventral thoracic disc phenotype of Scer\GAL4hs.2sev, eyScer\UAS.cHa
Coexpression of eyScer\UAS.cHa and tkvCA.Scer\UAS under control of Scer\GAL4hs.2sev results in large ectopic "eyes" (using antibodies against elav to visualize eye differentiation) in both wing and leg discs in regions far from the anterior-posterior compartment boundary.
Suppression by Df(2L)b82a2 or p38bDN.Scer\UAS (expressed under the control of Scer\GAL471B) of the wing phenotype caused by tkvCA.Scer\UAS expressed under the control of Scer\GAL471B is reduced if the flies are also coexpressing p38bScer\UAS.cAa. The wing disc is overgrown if tkvCA.Scer\UAS is expressed under the control of Scer\GAL469B. This phenotype is strongly suppressed by coexpression of either p38ba.Scer\UAS or p38bDN.Scer\UAS.
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 6 )|