A 15kb genomic fragment containing sqd, in which the alternatively spliced exons have been replaced with the corresponding region of a cDNA encoding the sqdS isoform.
sqdS rescues sqdj4B4/Df(3R)l26c
sqdS rescues sqdj4B4/Df(3R)urd
sqdS rescues sqdj4B4/sqdix50
sqdS rescues sqdj4B4/sqdix77
sqdS rescues sqdj4B4
sqdS partially rescues sqd1
sqdS partially rescues Df(3R)urd/sqdix50
sqdS fails to rescue sqd1
Expression of the sqdB isoform is not sufficient to rescue the sqd1 dorsal-ventral patterning defects, such that the eggs remain unfertilised.
The nurse cell chromosome defect seen in sqd1 homozygotes is partially rescued by 2 copies of sqdS, amd almost completely rescued by sqdS + sqdB or + sqdA.
68.9% of eggs derived from homozygous sqd1 females carrying sqdS are wild type. 98.4% of eggs derived from homozygous sqd1 females carrying both sqdA and sqdS are wild type. Partially rescues the lethality of sqdix50/Df(3R)urd.