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General Information
Symbol
Dmel\sli532
Species
D. melanogaster
Name
FlyBase ID
FBal0096690
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C15880071T
Reported nucleotide change:
C1428T
Amino acid change:
A450V | sli-PA; A450V | sli-PB; A474V | sli-PC; A450V | sli-PD; A474V | sli-PE; A474V | sli-PF
Reported amino acid change:
A?V
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: A?V. Nucleotide substitution: C1428T.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
7.1% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is adult. Nerve cord length is 76% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is moderate. 2.9 ventral oblique muscles per segment cross the midline on the dorsal surface of the ventral nerve cord, instead of having migrated to the edges and inserted into the ectoderm.
Mesectodermal cell distribution is normal. Axon trajectories in the CNS show misdirection towards the midline. The commissural tracts are thickened and show poor definition of anterior and posterior commissures. Longitudinal tracts are thinned. During stage 12/0, pioneers of the longitudinal tracts show misdirection and crossing of the midline. The ventral oblique muscle phenotype of crossing the midline is less marked than for sli2.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
sli532 has ventral nerve cord phenotype, enhanceable by robo[+]/robo11
Additional Comments
Genetic Interactions
Statement
Reference
Percentage of segments with midline crossovers in robo1/sli532 transheterozygotes is 46%.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sli532
Name Synonyms
Secondary FlyBase IDs
    References (2)