|Name||Saccharomyces cerevisiae UAS construct a of Matsuzaki||FlyBase ID||FBal0096724|
|Feature type||allele||Associated gene||Dmel\pros|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
(Liu et al., 2002, Mettler et al., 2006, Li and Vaessin, 2000, Kumar and Moses, 2001, Manning and Doe, 1999, Reddy and Rodrigues, 1999, Ragone et al., 2001, Sen et al., 2003, Kumar and Moses, 2001, Bello et al., 2006, Hartl et al., 2011, Andrews et al., 2009, Kurusu et al., 2009, Cabernard and Doe, 2009, Colonques et al., 2011)
|Phenotype Manifest In|
Larvae expressing pros[Scer\UAS.cMa] under the control of pros[Scer\UAS.cMa] (using heat shock) show a marked decrease in the number of mitotically active cells in the brain compared to controls. This reduction is seen both in the outer proliferation centre and in the central brain.
Expression of pros[Scer\UAS.cMa] in the neuroblasts under the control of Scer\GAL4[wor.PA] results in depletion of larval neuroblast numbers.
Ectopic expression of prosScer\UAS.cMa, under the control of Scer\GAL4en-e16E causes a precocious stop in cell division within the NB7-3 lineage.
When prosScer\UAS.cMa is driven by Scer\GAL4sca-P309, a striking reduction in external structures on the adult antenna is seen. No increase in the number of glia or neurons is seen.
Expression of prosScer\UAS.cMa under the control of Scer\GAL4dpp.blk1 inhibits furrow reincarnation in the eye disc.
When prosScer\UAS.cMa is driven by Scer\GAL4eg-Mz360 or Scer\GAL4sca-4512 no increase in NGB6-4t-derived glial cells is seen.
Expression of prosScer\UAS.cMa under the control of Scer\GAL4Kr.PM in embryos results in thinning and disruptions in the ventral nerve cord, and reduced epidermal and mesodermal structures. There is a strong reduction in BrdU labeling in these embryos compared to wild type.
Animals expressing prosScer\UAS.cMa under the control of Scer\GAL4sca-109-68 die as pharate adults and are virtually bald, having less than 1% of the normal external sense organ bristles in the notum and eye. The external sense organs lack both the bristle and socket.
prosScer\UAS.cMa/Scer\GAL4αTub84B.PL is a suppressor of neuroanatomy defective | somatic clone phenotype of brat11
Scer\GAL4Act.PU/prosScer\UAS.cMa is a suppressor | partially | somatic clone of neuroanatomy defective | somatic clone | adult stage phenotype of mir-279S096207
Scer\GAL4elav.Switch.PO, prosScer\UAS.cMa is a suppressor of cell cycle defective | larval stage phenotype of Scer\GAL4elav.Switch.PO, prosScer\UAS.cMa
|Phenotype Manifest In|
prosScer\UAS.cMa/Scer\GAL4αTub84B.PL is a suppressor of embryonic/larval brain | somatic clone phenotype of brat11
Scer\GAL4Act.PU/prosScer\UAS.cMa is a suppressor | partially | somatic clone of carbon dioxide sensitive neuron | ectopic | somatic clone phenotype of mir-279S096207
Scer\GAL4elav.Switch.PO, prosScer\UAS.cMa is a suppressor of brain | larval stage phenotype of Scer\GAL4elav.Switch.PO, prosScer\UAS.cMa
Scer\GAL4elav.Switch.PO/prosScer\UAS.cMa is a suppressor of brain | larval stage phenotype of Scer\GAL4elav.Switch.PO, tllScer\UAS.cKa
Expression of pros[Scer\UAS.cMa] under the control of Scer\GAL4[Act.PU] suppresses the formation of ectopic CO[] neurons on the maxillary palp caused by mir-279[S096207] clones in 37% of animals.
Co-overexpression of pros[Scer\UAS.cMa] and tll[Scer\UAS.cKa] by Scer\GAL4[elav.Switch.PO] rescues the tll[Scer\UAS.cKa]-induced brain hyperplasia in third instar larvae.
Expression of prosScer\UAS.cMa, under the control of Scer\GAL4αTub84B.PL, in brat11 mutant larval clones significantly suppresses the overproliferation phenotype in these clones in the central larval brain. Over 90% of Scer\GAL4αTub84B.PL>prosScer\UAS.cMa, brat11 clones in the central brain have <100 cells, while over 80% of brat11 clones have 200-1000 cells.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
Saccharomyces cerevisiae UAS construct a of Matsuzaki
|Secondary FlyBase IDs|
|References ( 15 )|