Border follicle cell migration is disrupted in mosaic egg chambers containing homozygous follicle cell clones; 90% of clusters containing one or two mutant border cells complete their migration to the oocyte, but clusters containing two or more mutant border cells either have incomplete migration or never migrate away from the anterior of the egg chamber. In every case in which border cell migration is impaired, both border cells and anterior stretched follicle cells are mutant. In cases where the border cells do not detach from the anterior of the egg chamber, a mix of mutant and wild-type border cells are seen.
The severity of the border follicle cell migration defects seen in females expressing par-1dsRNA.Scer\UAS.cMDa under the control of Scer\GAL4c306 are increased if the flies are also heterozygous for par-127C1.
Border follicle cell migration is disrupted in par-1k06323/par-127C1 females.
par-1k06323/par-127C1 border follicle cells that fail to detach from the anterior of the egg chamber have longer protrusions on average than wild-type border follicle cells. In addition , one to three cell fragments are often seen along the migration pathway in the mutant egg chambers.
Heterozygous egg chambers are indistinguishable from wild type.
Homozygous clones induced in the follicle cells result in defects in border cell migration; the border cells fail to initiate migration and remain at or near the anterior tip of the egg chamber even in stage 10.