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General Information
Symbol
Dmel\par-127C1
Species
D. melanogaster
Name
FlyBase ID
FBal0096797
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
27C1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G19470813A

Reported amino acid change:

G?A

Comment:

Sincle nucleotide change in a 5' splice site.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation in a 5' splice site.

Nucleotide substitution: G?A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Border follicle cell migration is disrupted in mosaic egg chambers containing homozygous follicle cell clones; 90% of clusters containing one or two mutant border cells complete their migration to the oocyte, but clusters containing two or more mutant border cells either have incomplete migration or never migrate away from the anterior of the egg chamber. In every case in which border cell migration is impaired, both border cells and anterior stretched follicle cells are mutant. In cases where the border cells do not detach from the anterior of the egg chamber, a mix of mutant and wild-type border cells are seen.

The severity of the border follicle cell migration defects seen in females expressing par-1dsRNA.Scer\UAS.cMDa under the control of Scer\GAL4c306 are increased if the flies are also heterozygous for par-127C1.

Border follicle cell migration is disrupted in par-1k06323/par-127C1 females.

par-1k06323/par-127C1 border follicle cells that fail to detach from the anterior of the egg chamber have longer protrusions on average than wild-type border follicle cells. In addition , one to three cell fragments are often seen along the migration pathway in the mutant egg chambers.

Heterozygous egg chambers are indistinguishable from wild type.

Homozygous clones induced in the follicle cells result in defects in border cell migration; the border cells fail to initiate migration and remain at or near the anterior tip of the egg chamber even in stage 10.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

l(2)27C127C1 taiunspecified double heterozygous egg chambers show defects in border cell migration.

l(2)27C127C1 l(2)17E117E1 double transheterozygotes have border cell migration defects in more than 50% of egg chambers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that causes defects in border cell migration when homozygous clones are induced in the follicle cells.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)