Coordinates of amino acid replacement are numbered according to GenBank accession AAK49526.1.
Amino acid replacement: K664term.
A6616413T
K664term | jing-PD; K664term | jing-PH; K922term | jing-PI; K664term | jing-PJ
K664term
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
femur & bract | somatic clone
Homozygous clones in the abdomen show a strong decrease in pigmentation.
Bristles in homozygous clones in the femur show loss of bracts, suggesting a transformation to a more proximal fate. Internalised vesicles that seem to have detached from the leg cuticle are also seen.
Homozygous clones in the wing blade are generally associated with a decrease or absence of wing vein differentiation. this phenotype is stronger if the clone affects both the dorsal and ventral aspects of the same vein. In addition, some clones adjacent to, but not including a longitudinal vein induce the nonautonomous elimination of that vein. Occasionally, ectopic vein differentiation is seen abutting a homozygous clones.
Homozygous clones in the alula cause a reduction in its size and its fusion with the main portion of the wing blade. The clones may also segregate from the cuticle and cause an internal vesicle.
The border cells may fail to migrate in egg chambers containing homozygous somatic clones. In mosaic egg chambers in which all of the border cells are heterozygous, they migrate normally. In mosaic egg chambers in which all border cells are homozygous, migration of the border cells fails. Border cell clusters composed of a mixture of homozygous and heterozygous cells show several different types of behaviour. Clusters containing a single heterozygous cell fail to migrate, although the heterozygous cell typically moves to the front of the cluster. Clusters containing a single homozygous cell migrate normally. Clusters containing two or more heterozygous cells frequently split into groups, with the heterozygous cells detaching from the homozygous cells and migrating partway towards the oocyte. In other cases, mixed clusters stay together as one group and migrate partway. In a few cases the border cell cluster becomes very extended, with the heterozygous cells migrating in a line, and the homozygous cells trailing behind.
Homozygous clones induced in the follicle cells result in defects in border cell migration; the border cells fail to initiate migration and remain at or near the anterior tip of the egg chamber even in stage 10.
jing22F3 has border follicle cell | somatic clone phenotype, non-suppressible by slbohs.PM
The partial transformation of wing to haltere seen in Pc15 heterozygotes is enhanced by jing22F3/+.
Df(2R)vg-D, AsxXF23, Pcl15/+ flies have almost normal wings. If the flies also carry jing22F3, the arrangement of wing bristles at the posterior wing margin becomes disorganised and there is an increase in the appearance of cuticle patches containing a high density of small trichomes, indicative of a partial wing-to-haltere transformation.
Selected as: a mutation that causes defects in border cell migration when homozygous clones are induced in the follicle cells.