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General Information
Symbol
Dmel\ebi1-334.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0096974
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-ebiDN
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a dominant negative form of ebi.

The expression of the first 334 amino acids of ebi is governed by GMR regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

After eclosion, ebi1-334.GMR/+ flies possess a near-normal complement of photoreceptors in each ommatidium. Five weeks later, however, these retinas are severely degenerated.

One copy of P{GMR-ebi.1-334} produces a slightly abnormal rough-eye phenotype, and two copies produces a severe rough-eye phenotype.

5 week old ebi1-334.GMR/+ photoreceptor cells in the eye show defective mitochondria with swollen and abnormal cristae.

Expression of ebi1-334.GMR causes a mild defect in eye morphology.

ebi1-334.GMR homozygotes have a mild rough eye phenotype.

ebi1-334.GMR causes a weak eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

ebi1-334.GMR has retina | progressive phenotype, enhanceable by Diap1[+]/Diap14

ebi1-334.GMR has eye phenotype, enhanceable by Dl9P/Dl[+]

Suppressed by
Statement
Reference

ebi1-334.GMR has retina | progressive phenotype, suppressible by hep[+]/hepr75

ebi1-334.GMR has eye phenotype, suppressible by +/Df(2R)X1

ebi1-334.GMR has eye phenotype, suppressible by Jra1/Jra[+]

ebi1-334.GMR has retina | progressive phenotype, suppressible by Jra1/Jra[+]

ebi1-334.GMR has retina | progressive phenotype, suppressible by Df(3L)H99/+

ebi1-334.GMR has ommatidium phenotype, suppressible | partially by rno5/rno[+]

ebi1-334.GMR has eye phenotype, suppressible | partially by rno2/rno[+]

NOT suppressed by
Statement
Reference

ebi1-334.GMR has retina | progressive phenotype, non-suppressible by hid05014/hid[+]

Enhancer of
NOT Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference

Df(2R)X1/+ or Jra1/+ suppresses the rough eye phenotype seen in flies with two copies of ebi1-334.GMR.

Df(3L)H99/+, Jra1/+, hepr75/+, but not hid05014/+, suppresses the late-onset retinal degeneration phenotype of ebi1-334.GMR/+ flies. Diap14/+ enhances this phenotype.

Expression of ebi1-334.GMR strongly enhances the eye morphology phenotype of Scer\GAL4GMR.PF>chnGS17605 and Scer\GAL4GMR.PF>chnGS11450 flies but fails to enhance the eye phenotype of Scer\GAL4GMR.PF>chnGS17892, Scer\GAL4GMR.PF>chnScer\UAS.cTa and Scer\GAL4GMR.PF>chnGS2112 flies.

The mild rough eye phenotype of ebi1-334.GMR homozygotes is almost completely suppressed by rno2/+ or rno5/+.

The combination of ebi1-334.GMR and Dl9P/+ leads to flies with a significantly rough eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Scer\GAL4GMR.PU-mediated expression of ebiScer\UAS.cTa rescues the retinal degeneration phenotype seen in 5-week old ebi1-334.GMR/+ flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
ebi1-334.GMR
Name Synonyms
Secondary FlyBase IDs
    References (5)