Allele Dmel\kn^col-3

General Information
Symbol	Dmel\kn^col-3	Species	D. melanogaster
Name		FlyBase ID	FBal0097025
Feature type	allele	Associated gene	Dmel\kn
Also Known As	col³

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Crozatier and Vincent, 1999)
Mutagen	ethyl methanesulfonate (Crozatier et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Crozatier et al., 1999)
Phenotype Manifest In
	abdominal 1 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 2 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 3 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 4 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 5 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 6 dorsal acute muscle 3 (Crozatier and Vincent, 1999) abdominal 7 dorsal acute muscle 3 (Crozatier and Vincent, 1999) cephalopharyngeal skeleton (Crozatier et al., 1999) embryonic/larval somatic muscle (Crozatier and Vincent, 1999) embryonic head (Crozatier and Vincent, 1999) lateral process (Crozatier et al., 1999) mesothoracic dorsal acute muscle 4 (Crozatier and Vincent, 1999) metathoracic dorsal acute muscle 4 (Crozatier and Vincent, 1999)
Detailed Description
	Statement Reference The number of SE2 neurons is normal in kn[col-1]/kn[col-3] mutant animals. (Losada-Pérez et al., 2010) Muscle DA3^A/DA4^T is missing or (in a few cases) reduced to a thinned muscle. This phenotype is highly penetrant and specific. (Crozatier and Vincent, 1999) Lethality occurs during the late embryonic to first larval instar stage. Homozygous and hemizygous embryos have head defects; the ventral arms are missing and the lateralgraten are reduced. The T-ribs in the floor of the pharynx, and the antennal, maxillary or hypopharyngeal sensory organs are present and a normal pattern of internal sensory structures is seen. The embryos that hatch do not grow and tend to crawl out of the medium, suggesting that they are unable to feed. (Crozatier et al., 1999)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	kn^col-3 is rescued by kn^+m5 (Crozatier et al., 1999, Crozatier and Vincent, 1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	col³ (Crozatier et al., 1999, Vervoort et al., 1999, Crozatier and Vincent, 1999, Baumgardt et al., 2007, Benito-Sipos et al., 2011, Losada-Pérez et al., 2010) kn^col-3
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Benito-Sipos et al., 2011, Development 138(24): 5311--5320 Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. [FBrf0216799] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Baumgardt et al., 2007, PLoS Biol. 5(2): e37 Specification of neuronal identities by feedforward combinatorial coding. [FBrf0195184] Crozatier et al., 1999, Development 126(19): 4385--4394 Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment. [FBrf0111350] Crozatier and Vincent, 1999, Development 126(7): 1495--1504 Requirement for the Drosophila COE transcription factor Collier in formation of an embryonic muscle: transcriptional response to Notch signalling. [FBrf0108163] Vervoort et al., 1999, Curr. Biol. 9(12): 632--639 The COE transcription factor collier is a mediator of short-range hedgehog-induced patterning of the Drosophila wing. [FBrf0109132]

Allele Dmel\kncol-3

Allele Dmel\kn^col-3