Allele Dmel\Thiolase⁰⁰⁶²⁸

General Information
Symbol	Dmel\Thiolase⁰⁰⁶²⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0097090
Feature type	allele	Associated gene	Dmel\Thiolase

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Kolhekar et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:19,757,428..19,757,435 (Kolhekar et al., 1997, BDGP Project Members, 1994-1999, Lukacsovich et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion in the intergenic region between ken and Thiolase (at position 16,670-16,677, coordinates according to EMBL accession record AB010261). (Lukacsovich et al., 1999)
Caused by insertion	P{PZ}ken⁰⁰⁶²⁸ (Kolhekar et al., 1997, BDGP Project Members, 1994-1999, Lukacsovich et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (BDGP Project Members, 1994-1999)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
NOT Enhancer of
Statement Reference Thiolase[+]/Thiolase⁰⁰⁶²⁸ is a non-enhancer of visible \| heat sensitive phenotype of peb¹ (Wilk et al., 2004)
NOT Suppressor of
Statement Reference Thiolase[+]/Thiolase⁰⁰⁶²⁸ is a non-suppressor of visible \| heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Thiolase[+]/Thiolase⁰⁰⁶²⁸ is a non-enhancer of eye \| heat sensitive phenotype of peb¹ (Wilk et al., 2004)
NOT Suppressor of
Statement Reference Thiolase[+]/Thiolase⁰⁰⁶²⁸ is a non-suppressor of eye \| heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Thiolase^k09828 (BDGP Project Members, 1994-1999)
Comments	The P{PZ}ken⁰⁰⁶²⁸ insertion is in the intergenic region between the divergently transcribed ken and Thiolase genes. P{PZ}ken⁰⁰⁶²⁸ fails to complement P{PZ}ken⁰²⁹⁷⁰ (an insertion in the ken coding region) and P{lacW}Thiolase^k09828, but P{PZ}ken⁰²⁹⁷⁰ and P{lacW}Thiolase^k09828 complement each other. This indicates that the P{PZ}ken⁰⁰⁶²⁸ insertion is affecting both the ken and Thiolase genes and that the P{lacW}Thiolase^k09828 insertion is a mutation in the Thiolase gene.
Stocks ( 0 )

Notes on Origin
Discoverer	A. Spradling.

Comments
	The P{PZ}ken⁰⁰⁶²⁸ insertion may affect the Thiolase gene as well as the ken gene. (Lukacsovich et al., 1999) Complements Phm^k07623. (Kolhekar et al., 1997) This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	l(2)00628 (Lukacsovich et al., 1999) l(2)00628⁰⁰⁶²⁸ P942 (Kolhekar et al., 1997) Thiolase⁰⁰⁶²⁸
Name Synonym
Secondary FlyBase IDs
	FBal0007950
References ( 6 )
Research paper	Wilk et al., 2004, Genetics 168(1): 281--300 Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight. [FBrf0180294] Lukacsovich et al., 1999, Genomics 57(1): 43--56 The Drosophila melanogaster 60A chromosomal division is extremely dense with functional genes: their sequences, genomic organization, and expression. [FBrf0108232] Kolhekar et al., 1997, J. Neurosci. 17(4): 1363--1376 Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. [FBrf0092591]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\Thiolase00628

Allele Dmel\Thiolase⁰⁰⁶²⁸