Allele Dmel\Nop60B¹

General Information
Symbol	Dmel\Nop60B¹	Species	D. melanogaster
Name		FlyBase ID	FBal0097207
Feature type	allele	Associated gene	Dmel\Nop60B

Allele class	hypomorphic allele - genetic evidence
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Giordano et al., 1999)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{PZ}toc⁰¹³⁶¹ (Giordano et al., 1999)
Nature of the lesion	Statement Reference P{PZ} insertion in the 5' end of the gene. (Giordano et al., 1999)
Caused by insertion	P{PZ}Nop60B¹ (FlyBase, 1992-)
Cytology
Phenotypic Data
Phenotypic Class
	developmental rate defective \| recessive (Giordano et al., 1999) female sterile \| partially \| recessive (Giordano et al., 1999) increased cell death \| recessive (Giordano et al., 1999) viable (Giordano et al., 1999) visible \| recessive (Giordano et al., 1999)
Phenotype Manifest In
	adult abdomen & macrochaeta (Giordano et al., 1999) adult cuticle & adult abdomen (Giordano et al., 1999) egg (Giordano et al., 1999) egg chamber (Giordano et al., 1999) embryo (Giordano et al., 1999) nurse cell & nucleus (Giordano et al., 1999)
Detailed Description
	Statement Reference Homozygous flies have a pleiotropic phenotype that includes an extreme reduction in body size, developmental delay (essentially due to a 4-5 day prolongation of the larval stage), defects in the abdominal cuticle, strong reduction in the length and thickness of abdominal bristles and reduced female fertility. Morphological abnormalities are seen in homozygous ovaries; some egg chambers beyond stage 7 of oogenesis degenerate, and fragmented or condensed nurse cell nuclei which are irregularly shaped are often seen in these egg chambers. Apoptosis occurs in the abnormal ovaries. Homozygous females lay a reduced number of mature eggs and approximately 15% of the embryos produced fail to hatch. These embryos show asynchronous and abnormal development, which is accompanied by diffuse apoptotic cell death. (Giordano et al., 1999)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Nop60B^k05318 (Giordano et al., 1999) Nop60B^k06308 (Giordano et al., 1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Precise excision of the P{PZ} element gives wild type revertants. (Giordano et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	mfl¹ (Giordano et al., 1999, ) Nop60B¹
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Giordano et al., 1999, J. Cell Biol. 144(6): 1123--1133 minifly, A Drosophila gene required for ribosome biogenesis. [FBrf0108186]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Allele Dmel\Nop60B1

Allele Dmel\Nop60B¹