Lrrk^e03680/+ blocks the increased quantal content seen in larval NMJs expressing GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Mhc.PW, via a decrease in excitatory junction current (EJC) amplitude.

The increase in quantal content in neuromuscular junctions of GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^C142 larvae is partially suppressed by CaMKII^{T287D.Scer\UAS} : There is an decrease of 25% (p < 0.01) (55% decrease when corrected for nonlinear summation) in quantal content compared to GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^C142 larvae. This decrease is due to a significant reduction (p < 0.01) in the amplitude of excitatory postsynaptic potentials (EPSPs). There is no effect on mini-EPSPs. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae). wit^HA4/wit^HA5 suppresses the increase in quantal content seen in the neuromuscular junctions of GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^C142 larvae. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae). wit^HA4/wit^HA5 suppresses the increase in the excitatory postsynaptic potential amplitude seen in the neuromuscular junctions of Rat\CaMKIINα^{I.Scer\UAS.cHa}; Scer\GAL4^C142 larvae. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae). The excitatory postsynaptic potential (EPSP) and mini-EPSP amplitudes are significantly decreased in wit^HA4/wit^HA5 larvae by the presence of GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC} with Scer\GAL4^C142. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae).

The addition off GluRIIA^{M614R.Scer\UAS.T:Hsap\MYC} to hiw mutants leads to a an 18% decrease in quantal size, no change in the size of the evoked response, and a compensatory 30% increase in quantal content.