FlyBase Allele Report: Dmel\eIF2α[G0272]

General Information

Symbol

Dmel\eIF2α^G0272

Species

D. melanogaster

Name

FlyBase ID

FBal0098133

Feature type

allele

Associated gene

Dmel\eIF2α

Associated Insertion(s)

P{lacW}eIF2α^G0272

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Penney et al., 2012)

Mutagen

P-element activity

(Schäfer et al., 1999.6.15)

Progenitor genotype

Associated Insertion(s)

P{lacW}eIF2α^G0272

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:16,447,216..16,447,236 [+]

(Penney et al., 2012, Peter et al., 2002, Schäfer et al., 1999.6.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426960

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Penney et al., 2012)

abnormal neurophysiology | larval stage

(Penney et al., 2012)

decreased size | larval stage

(Penney et al., 2012)

lethal | pharate adult stage

(Peter et al., 2002)

lethal | pupal stage

(Peter et al., 2002)

lethal | recessive

(Schäfer et al., 1999.6.15)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Penney et al., 2012)

larval somatic muscle

(Penney et al., 2012)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

eIF2α^G0272 is a non-enhancer of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

NOT Suppressor of

Statement

Reference

eIF2α^G0272 is a non-suppressor of abnormal neurophysiology | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

eIF2α^G0272 is a non-enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

NOT Suppressor of

Statement

Reference

eIF2α^G0272 is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of GluRIIA^SP16/Df(2L)cl-h4

(Penney et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11892

w^67c23 P{lacW}eIF2α^G0272/FM7c

Kyoto

111832

y¹ w^* P{lacW}eIF2α^G0272 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.6.15)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426960

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

eIF2α^G0272

(Penney et al., 2012)

l(1)G0272

(Peter et al., 2002)

l(1)G0272^G0272

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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