FB2025_01 , released February 20, 2025
Allele: Dmel\β-SpecG0198
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General Information
Symbol
Dmel\β-SpecG0198
Species
D. melanogaster
Name
FlyBase ID
FBal0098171
Feature type
allele
Associated gene
Dmel\β-Spec
Associated Insertion(s)
P{lacW}β-SpecG0198
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Garbe et al., 2007)
Mutagen
P-element activity
(Schäfer et al., 1999.6.15)
Progenitor genotype
Associated Insertion(s)
P{lacW}β-SpecG0198
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ426974
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      β-SpecG0198/Y embryos show mild midline axon guidance defects, with on average less than one medial longitudinal fascicle ectopically crossing the midline per embryo.

      (Garbe et al., 2007)

      Lethality occurs from the third larval instar through to the pharate adult stage. Third instar larvae and pupae are short.

      (Peter et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      β-SpecG0198 has abnormal neuroanatomy phenotype, enhanceable by α-Speclm88

      (Garbe et al., 2007)

      β-SpecG0198 has abnormal neuroanatomy phenotype, enhanceable by sli2/robo[+]/robo11

      (Garbe et al., 2007)
      Enhancer of
      Statement
      Reference

      β-SpecG0198 is an enhancer of abnormal neuroanatomy | recessive phenotype of α-Speclm88

      (Garbe et al., 2007)

      β-SpecG0198 is an enhancer of abnormal neuroanatomy phenotype of robo[+]/robo11, sli2

      (Garbe et al., 2007)

      β-SpecG0198 is an enhancer of abnormal neuroanatomy | dominant phenotype of sli2

      (Garbe et al., 2007)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      β-SpecG0198 has medial longitudinal fascicle | ectopic phenotype, enhanceable by α-Speclm88

      (Garbe et al., 2007)

      β-SpecG0198 has medial longitudinal fascicle | ectopic phenotype, enhanceable by sli2/robo[+]/robo11

      (Garbe et al., 2007)
      Enhancer of
      Statement
      Reference

      β-SpecG0198 is an enhancer of medial longitudinal fascicle | ectopic phenotype of α-Speclm88

      (Garbe et al., 2007)

      β-SpecG0198 is an enhancer of medial longitudinal fascicle | ectopic phenotype of robo[+]/robo11, sli2

      (Garbe et al., 2007)

      β-SpecG0198 is an enhancer of larval neuron phenotype of sli2

      (Garbe et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      β-SpecG0198/Y; α-Speclm88/+ embryos show a mild enhancement of the midline defects seen in β-SpecG0198/Y embryos. β-SpecG0198/Y; α-Speclm88/α-Speclm88 embryos causes an enhancement of the number of times the medial longitudinal fascicle ectopically cross the midline compared to either single mutant.

      β-SpecG0198; sli2, robo1/+ show an enhancement of the midline axon guidance defects seen in β-SpecG0198/Y and sli2, robo1/+ embryos as more medial longitudinal fascicles ectopically cross the midline in the triple mutant.

      The Apterous neuron axon guidance phenotype of sli2/+ embryos is enhanced in β-SpecG0198/Y; sli2/+ embryos.

      (Garbe et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.6.15)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      G0198
      (Garbe et al., 2007)
      l(1)G0198
      (Peter et al., 2002)
      l(1)G0198G0198
      (Schäfer et al., 1999.6.15)
      β-SpecG0198
      Name Synonyms
      Secondary FlyBase IDs
        References (3)