FlyBase Allele Report: Dmel\hep[CA.UAS]

(Yanku et al., 2018, Zhang et al., 2015, Ma et al., 2013, Pechkovsky et al., 2013, Ma et al., 2012, Geuking et al., 2009, Geuking et al., 2005)

eye, with Scer\GAL4^GMR.PU

(Ren et al., 2017)

eye, with Scer\GAL4^sev.PU

(Ma et al., 2014, Hwang et al., 2010)

eye | somatic clone, with Scer\GAL4^GMR.PF

(Igaki et al., 2006)

eye disc, with Scer\GAL4^sev.PU

(Ma et al., 2014)

eye disc | third instar larval stage, with Scer\GAL4^GMR.PF

(Zhang et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^sev.PU

(Hwang et al., 2010)

eye disc morphogenetic furrow | third instar larval stage, with Scer\GAL4^GMR.PU

(Ren et al., 2017)

follicle cell, with Scer\GAL4^GR1

(Etchegaray et al., 2012)

lamellocyte, with Scer\GAL4^He.PZ

(Zettervall et al., 2004)

lamellocyte, with Scer\GAL4^Hml.PG

(Zettervall et al., 2004)

melanotic mass, with Scer\GAL4^He.PZ

(Zettervall et al., 2004)

melanotic mass, with Scer\GAL4^Hml.PG

(Zettervall et al., 2004)

neuroblast | larval stage, with Scer\GAL4^wor.PA

(Kuang et al., 2014)

ventral adult lateral neuron & axon, with Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

ventral midline of embryo | embryonic stage 13, with Scer\GAL4^sim.PS

(Barros and Bossing, 2021)

ventral midline of embryo | embryonic stage 13 | conditional, with Scer\GAL4^sim.PS

(Barros and Bossing, 2021)

wing, with Scer\GAL4^vg.PU

(Kirchner et al., 2007)

wing | ectopic, with Scer\GAL4^rn-GAL4-5

(Worley et al., 2018)

wing margin, with Scer\GAL4^vg.PU

(Kirchner et al., 2007)

wing vein, with Scer\GAL4^vg.PU

(Kirchner et al., 2007)

wing vein L5, with Scer\GAL4^CY2

(Guichard et al., 2006)

Detailed Description

Statement

Reference

The expression of Traf6^UAS.cSa under the control of Scer\GAL4^sim.PS suppresses mitosis in the ventral midline of stage 13 embryos.

(Barros and Bossing, 2021)

40-hour- (but not 24-hour-) expression of hep^CA.UAS under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) leads to occasional ectopic wings compared to controls.

(Worley et al., 2018)

Expression of hep^CA.UAS under the control of Scer\GAL4^GMR.PF results in a small eye phenotype.

(Yanku et al., 2018)

The expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PU leads to a severe increase in apoptosis in the third instar larval eye disc morphogenetic furrow and to small eye and rough eye phenotypes in adults, as compared to controls; expression under the control of Scer\GAL4^ptc-559.1 leads to a severe increase in apoptosis around the anterior-posterior compartment boundary of the third instar larval wing disc and to a highly penetrant anterior crossvein loss in the adult wing, as compared to controls.

(Ren et al., 2017)

Pulse (16 hr) expression of hep^CA.Scer\UAS under the control of Scer\GAL4^pnr-MD237, using tub-Gal80ts to limit the time of expression to third larval instar results in formation of a giant syncytium comprising the whole of Scer\GAL4^pnr-MD237 expressing patches in the larval epidermis.

(Wang et al., 2015)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PF induces cell death in the eye disc and generates a small-eye phenotype.

(Zhang et al., 2015)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^wor.PA induces neuroblast loss in larval brains.

(Kuang et al., 2014)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^sev.PU triggers extensive cell death in larval eye discs and produces rough eyes with reduced sizes.

(Ma et al., 2014)

Expression of constitutively active hep^CA.Scer\UASunder the control of either Scer\GAL4^{elav.Switch.PO} or Scer\GAL4^{αTub84B.Switch.PK} results in a robust weakening of the regenerative response after axonal injury.

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^{elav.Switch.PO} results in a marked increase in the size of pigmented scar after injury.

(Soares et al., 2014)

Expression of the constitutively active hep^CA.Scer\UAS transgene, under the control of Scer\GAL4^pnr-MD237, generates a small scutellum phenotype.

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^ptc-559.1 results in loss of the anterior cross vein.

(Ma et al., 2013)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PF results in reduced eclosion rates; 67% of flies eclose at 18[o]C and 0.75% at 24[o]C.

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a reduction in eye size; eye size is 17% of control in females and 18% in males.

(Pechkovsky et al., 2013)

Follicle cells expressing hep^CA.Scer\UAS under the control of Scer\GAL4^GR1 in unstarved flies display a hyper-engulfment phenotype in which they invade and surround apparently healthy nurse cells, culminating in the follicle cells engulfing intact nurse cells and inducing their death.

(Etchegaray et al., 2012)

Expression of hep^CA.Scer\UAS in the developing eye under the control of Scer\GAL4^GMR.PF induces JNK-mediated cell death and produces a small eye phenotype.

(Ma et al., 2012)

The eye-degeneration phenotype caused by expression of hep^CA.Scer\UAS under the control of Scer\GAL4^hs.2sev is not mitigated by feeding flies with linoleic acid and linolenic acid.

(Lee et al., 2011)

Expression of hep^CA.Scer\UAS driven by Scer\GAL4^sev.PU results in a rough eye phenotype. Large numbers of dead cells are detected in the eye imaginal disc of Scer\GAL4^sev.PU>hep^CA.Scer\UAS third instar larvae.

(Hwang et al., 2010)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PF produces a small eye phenotype.

(Geuking et al., 2009)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^vg.PU results in lethality at 25^oC, while at 18^oC the flies are viable and have wing defects. The wing defects seen at 18^oC include missing posterior wing-vein material, notches in the wing margins and held-out wings.

(Kirchner et al., 2007)

Weak expression of hep^CA.Scer\UAS in the posterior region of the wing using the Scer\GAL4^CY2 driver leads to a partial loss of the fifth longitudinal vein (L5).

(Guichard et al., 2006)

Overexpression of hep^CA.Scer\UAS in eye clones, under the control of Scer\GAL4^GMR.PF results in a severe eye phenotype with apparently massive levels of apoptosis.

(Igaki et al., 2006)

Expression of hep^CA.Scer\UAS, under the control of Scer\GAL4^ato.3.6, results in all dorsal cluster neurons crossing to the medulla, while in wild-type brains, the majority of these axons retract during pupal development and branch within the lobula.

(Srahna et al., 2006)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PF causes a reduction in eye size.

(Geuking et al., 2005)

Expression of hep^CA.Scer\UAS, under the control of Scer\GAL4^P2.4.Pdf, induces axonal overextension of the sLNv without increased arborization.

(Leyssen et al., 2005)

Expression of hep^CA.Scer\UAS, under the control of Scer\GAL4^e22c, leads to embryonic lethality before dorsal closure.

(Woolner et al., 2005)

When expression is driven by Scer\GAL4^He.PZ, hemocyte proliferation is unaffected, lamellocyte numbers are increased and crystal cells are unaffected. Melanotic masses form. Similar, though milder, effects are seen when expression is driven by Scer\GAL4^Hml.PG.

(Zettervall et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^rn-GAL4-5, hep^CA.UAS has visible | adult stage phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Worley et al., 2018)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has visible | adult stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has visible | adult stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible | partially by bsk^NIG.5680R/Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has visible | adult stage phenotype, suppressible | partially by bsk^NIG.5680R/Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by bsk^NIG.5680R/Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^ptc-559.1

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/bsk^NIG.5680R

(Ren et al., 2017)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by arm^NIG.11579R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by arm^NIG.11579R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by pan^VDRC.cUa/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by pan^VDRC.cUa/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by sgg^EP1576/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by sgg^EP1576/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by Axn^UAS.GFP, Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by Axn^UAS.GFP, Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by bsk¹/bsk[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by bsk¹/bsk[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by wg[+]/wg^l-8

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by wg[+]/wg^l-8

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by arm²/arm[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by arm²/arm[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size phenotype, suppressible by wg^NIG.4889R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by wg^NIG.4889R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has lethal | heat sensitive phenotype, suppressible by HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, suppressible by HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible by HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

Scer\GAL4^sev.PU, hep^CA.UAS has visible phenotype, suppressible by Scer\GAL4^sev.PU/park^UAS.Tag:MYC

(Hwang et al., 2010)

Scer\GAL4^sev.PU, hep^CA.UAS has increased cell death | third instar larval stage phenotype, suppressible by Scer\GAL4^sev.PU/park^UAS.Tag:MYC

(Hwang et al., 2010)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible by Mkk4^UAS.cGa, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, suppressible by Mkk4^UAS.cGa, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, suppressible by Mkk4^Mut.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, suppressible by Mkk4^Mut.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, suppressible by bsk^G258/bsk[+]

(Geuking et al., 2005)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn-GAL4-5, hep^CA.UAS has visible | adult stage phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Worley et al., 2018)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, non-suppressible by HUWE1^EY01689, Scer\GAL4^GMR.PF

(Yanku et al., 2018)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, non-suppressible by HUWE1^EY01689, Scer\GAL4^GMR.PF

(Yanku et al., 2018)

Scer\GAL4^pnr-MD237, hep^CA.UAS has increased cell size | third instar larval stage phenotype, non-suppressible by Cdk1^GL00262, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has abnormal cell shape | third instar larval stage phenotype, non-suppressible by aurB^GL00202/Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has increased cell size | third instar larval stage phenotype, non-suppressible by aurB^GL00202/Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has abnormal cell shape | third instar larval stage phenotype, non-suppressible by Dark^GD12048, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has increased cell size | third instar larval stage phenotype, non-suppressible by Dark^GD12048, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has abnormal cell shape | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has increased cell size | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has abnormal cell shape | third instar larval stage phenotype, non-suppressible by Cdk1^GL00262, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^sev.PU, hep^CA.UAS has visible phenotype, non-suppressible by ben¹

(Ma et al., 2014)

Scer\GAL4^GMR.PF, hep^CA.UAS has neoplasia phenotype, non-suppressible by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2013)

Scer\GAL4^GMR.PF, hep^CA.UAS has partially lethal - majority live | temperature conditional phenotype, non-suppressible by HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, non-suppressible by Mkk4^G673/Mkk4^G587

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, non-suppressible by Mkk4^G673/Mkk4^G587

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has abnormal size | adult stage phenotype, non-suppressible by Mkk4^Asp.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible | adult stage phenotype, non-suppressible by Mkk4^Asp.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, non-suppressible by Tab2[+]/Tab2^G71

(Geuking et al., 2005)

Scer\GAL4^GMR.PF, hep^CA.UAS has visible phenotype, non-suppressible by Tak1^unspecified

(Geuking et al., 2005)

Scer\GAL4^P2.4.Pdf, hep^CA.UAS has abnormal neuroanatomy phenotype, non-suppressible by Appl^d

(Leyssen et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^sim.PS/hep^CA.UAS is a suppressor of increased occurrence of cell division | embryonic stage 13 phenotype of Scer\GAL4^sim.PS, dl^UAS.cHa

(Barros and Bossing, 2021)

hep^CA.UAS/Scer\GAL4^GR1 is a suppressor of abnormal cell death | nutrition conditional phenotype of drpr^Δ5

(Etchegaray et al., 2012)

hep^CA.UAS, Scer\GAL4^Act5C.PI is a suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, shg^k03401

(Igaki et al., 2006)

hep^CA.UAS is a suppressor | partially of lethal | embryonic stage phenotype of Mtl^Δ, Rac1^J11, Rac2^Δ

(Woolner et al., 2005)

Other

Statement

Reference

Scer\GAL4^nub-AC-62, grim^RNAi.RHG.UAS, hep^CA.UAS, hid^RNAi.RHG.UAS, rpr^RNAi.RHG.UAS has increased size | larval stage phenotype

(Sulekh et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^vg.PU, hep^CA.UAS has wing phenotype, enhanceable by flw¹

(Kirchner et al., 2007)

NOT Enhanced by

Statement

Reference

Scer\GAL4^rn-GAL4-5, hep^CA.UAS has wing | ectopic phenotype, non-enhanceable by CtBP[+]/CtBP^87De-10

(Worley et al., 2018)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, hep^CA.UAS has eye phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has eye phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has eye phenotype, suppressible | partially by bsk^NIG.5680R/Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has eye disc morphogenetic furrow | third instar larval stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has eye disc morphogenetic furrow | third instar larval stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^GMR.PU, hep^CA.UAS has eye disc morphogenetic furrow | third instar larval stage phenotype, suppressible | partially by bsk^NIG.5680R/Scer\GAL4^GMR.PU

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^ptc-559.1

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/bsk^NIG.5680R

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior crossvein | third instar larval stage phenotype, suppressible | partially by Glyat^c02982/Glyat[+]

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior crossvein | third instar larval stage phenotype, suppressible | partially by Glyat^TH00482, Scer\GAL4^ptc-559.1

(Ren et al., 2017)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior crossvein | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/bsk^NIG.5680R

(Ren et al., 2017)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by wg[+]/wg^l-8

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by arm²/arm[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by wg^NIG.4889R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by arm^NIG.11579R/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by pan^VDRC.cUa/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by sgg^EP1576/Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by Axn^UAS.GFP, Scer\GAL4^GMR.PF

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by bsk¹/bsk[+]

(Zhang et al., 2015)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

Scer\GAL4^sev.PU, hep^CA.UAS has eye phenotype, suppressible by Scer\GAL4^sev.PU/park^UAS.Tag:MYC

(Hwang et al., 2010)

Scer\GAL4^sev.PU, hep^CA.UAS has eye disc | third instar larval stage phenotype, suppressible by Scer\GAL4^sev.PU/park^UAS.Tag:MYC

(Hwang et al., 2010)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by Mkk4^UAS.cGa, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by Mkk4^Mut.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

hep^CA.UAS has wing vein L5 phenotype, suppressible by Scer\GAL4^CY2/Bant\lef^UAS.cGa

(Guichard et al., 2006)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, suppressible by bsk^G258/bsk[+]

(Geuking et al., 2005)

NOT suppressed by

Statement

Reference

Scer\GAL4^rn-GAL4-5, hep^CA.UAS has wing | ectopic phenotype, non-suppressible by CtBP[+]/CtBP^87De-10

(Worley et al., 2018)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by HUWE1^EY01689, Scer\GAL4^GMR.PF

(Yanku et al., 2018)

Scer\GAL4^pnr-MD237, hep^CA.UAS has embryonic/larval epidermis | third instar larval stage phenotype, non-suppressible by Cdk1^GL00262, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has embryonic/larval epidermis | third instar larval stage phenotype, non-suppressible by aurB^GL00202/Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has embryonic/larval epidermis | third instar larval stage phenotype, non-suppressible by Dark^GD12048, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^pnr-MD237, hep^CA.UAS has embryonic/larval epidermis | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Scer\GAL4^sev.PU, hep^CA.UAS has eye phenotype, non-suppressible by ben¹

(Ma et al., 2014)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by Uev1A^GD6650/Scer\GAL4^GMR.PF

(Ma et al., 2013)

Scer\GAL4^ptc-559.1, hep^CA.UAS has anterior crossvein phenotype, non-suppressible by Scer\GAL4^pnr-MD237/Uev1A^GD6650

(Ma et al., 2013)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by Mkk4^G673/Mkk4^G587

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by Mkk4^Asp.UAS, Scer\GAL4^GMR.PF

(Geuking et al., 2009)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by Tab2[+]/Tab2^G71

(Geuking et al., 2005)

Scer\GAL4^GMR.PF, hep^CA.UAS has eye phenotype, non-suppressible by Tak1^unspecified

(Geuking et al., 2005)

Scer\GAL4^P2.4.Pdf, hep^CA.UAS has ventral adult lateral neuron & axon phenotype, non-suppressible by Appl^d

(Leyssen et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^sim.PS/hep^CA.UAS is a suppressor of ventral midline of embryo | embryonic stage 13 phenotype of Scer\GAL4^sim.PS, dl^UAS.cHa

(Barros and Bossing, 2021)

hep^CA.UAS/Scer\GAL4^GR1 is a suppressor of egg chamber | nutrition conditional phenotype of drpr^Δ5

(Etchegaray et al., 2012)

hep^CA.UAS/Scer\GAL4^GR1 is a suppressor of follicle cell | nutrition conditional phenotype of drpr^Δ5

(Etchegaray et al., 2012)

hep^CA.UAS is a suppressor | partially of embryo | dorsal closure stage phenotype of Mtl^Δ, Rac1^J11, Rac2^Δ

(Woolner et al., 2005)

hep^CA.UAS is a suppressor | partially of embryonic/first instar larval cuticle phenotype of Mtl^Δ, Rac1^J11, Rac2^Δ

(Woolner et al., 2005)

hep^CA.UAS/Scer\GAL4^hs.PB is a suppressor of embryonic dorsal epidermis | germline clone | rescuable maternal effect phenotype of Cka⁰⁵⁸³⁶

(Chen et al., 2002)

Other

Statement

Reference

Scer\GAL4^nub-AC-62, grim^RNAi.RHG.UAS, hep^CA.UAS, hid^RNAi.RHG.UAS, rpr^RNAi.RHG.UAS has wing pouch phenotype

(Sulekh et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

40-hour- (but not 24-hour-) expression of hep^CA.UAS under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in CtBP^87De-10/+ background leads to occasional ectopic wings compared to controls.

(Worley et al., 2018)

The increased apoptosis at the morphogenetic furrow of the third instar larval eye disc and the decreased eye size in adults resulting from the expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PU are significantly suppressed by the co-expression of either Glyat^TH00482 or bsk^NIG.5680R, or by heterozygosity for Glyat^c02982; the increased apoptosis around the anterior-posterior compartment boundary of the third instar larval wing disc and the highly penetrant loss of the anterior crossvein in the adult wing resulting from the expression of hep^CA.Scer\UAS under the control of Scer\GAL4^ptc-559.1 are also partially suppressed by the co-expression of either Glyat^TH00482 or bsk^NIG.5680R, or by heterozygosity for Glyat^c02982.

(Ren et al., 2017)

The formation of giant syncytia in the patches of dorsal larval epidermis expressing hep^CA.Scer\UAS under the control of Scer\GAL4^pnr-MD237 (using tub-Gal80ts to limit the expression to 16 hr-long pulse during the third instar) is not suppressed by co-expression of either Cdk1^GL00262, aurB^GL00202 or Dark^GD12048, the number of nuclei within the syncytia is also not changed.

(Wang et al., 2015)

ben¹ has no effect on the rough eye phenotype seen when hep^CA.Scer\UAS is expressed under the control of Scer\GAL4^sev.PU.

(Ma et al., 2014)

Loss of Uev1A, through co-expression of Uev1A^GD6650, fails to suppress the small scutellum phenotype found in flies expressing hep^CA.Scer\UAS under the control of Scer\GAL4^pnr-MD237.

(Ma et al., 2013)

Expression of hep^CA.Scer\UAS under the control of Scer\GAL4^GR1 partially rescues the cell death defects seen in drpr^Δ5 mutant starvation-induced degenerating egg chambers. Many abnormal egg chambers are still seen but, unlike in drpr^Δ5 mutants alone, enlargement of the follicle cells occurs and germline engulfment takes place. Hyper-engulfment, where follicle cells engulf intact nurse cells, takes place in some egg chambers.

(Etchegaray et al., 2012)

A Df(3L)H99 background fails to suppress the small eye phenotype in flies expressing egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

Expression of th^Scer\UAS.cHa fails to suppress the small eye phenotype in flies expressing egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

Expression of Nc^{C318G.Scer\UAS} fails to suppress the small eye phenotype in flies expressing egr^Scer\UAS.cIa under the control of Scer\GAL4^GMR.PF.

(Ma et al., 2012)

Co-expression of park^{Scer\UAS.T:Hsap\MYC} strongly suppresses the rough eye phenotype in flies and the increased cell death in third instar larval eye discs seen with expression of hep^CA.Scer\UAS driven by Scer\GAL4^sev.PU.

(Hwang et al., 2010)

Mkk4^G587/Mkk4^G673 does not suppress the small eye phenotype seen when hep^CA.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Co-expression of Mkk4^Scer\UAS.cGa suppresses the small eye phenotype seen when hep^CA.Scer\UAS is expression of Scer\GAL4^GMR.PF.

Co-expression of Mkk4^Asp.Scer\UAS is unable to suppress the small eye phenotype seen when hep^CA.Scer\UAS is expression of Scer\GAL4^GMR.PF.

Co-expression of Mkk4^Mut.Scer\UAS suppresses the small eye phenotype seen when hep^CA.Scer\UAS is expression of Scer\GAL4^GMR.PF.

(Geuking et al., 2009)

The wing defects caused by expression of hep^CA.Scer\UAS under the control of Scer\GAL4^vg.PU are enhanced in a flw¹/Y background; the wings are much smaller and are frequently notched and blistered. The double mutant flies are only 10% viable relative to their flw¹/+ ; hep^CA.Scer\UAS, Scer\GAL4^vg.PU control siblings.

(Kirchner et al., 2007)

Co-expression of bsk^{dsRNA.Scer\UAS} with hep^CA.Scer\UAS in eye clones, under the control of Scer\GAL4^GMR.PF results in partial suppression of the apoptotic eye phenotype observed in hep^CA.Scer\UAS mutant clones.

Overexpression of hep^CA.Scer\UAS in shg^k03401 mutant cephalic cells (i.e. cells in the larval brain and eye-antennal discs) expressing Ras85D^V12.Scer\UAS results in neither enhanced tumour growth nor metastatic behaviour.

(Igaki et al., 2006)

Expression of hep^CA.Scer\UAS, under the control of Scer\GAL4^P2.4.Pdf, in an Appl^d mutant background still induces the significant axonal extension seen when the transgene is expressed in a wild-type background.

(Leyssen et al., 2005)

Leaky expression of hep^CA.Scer\UAS, with no GAL4 driver, partially rescues the lethality and dorsal puckering phenotype of Rac1^J11 Rac2^Δ Mtl^Δ triple mutants.

(Woolner et al., 2005)

The dorsal open phenotype seen in homozygous Cka⁰⁵⁸³⁶ embryos derived from females carrying homozygous Cka⁰⁵⁸³⁶ germ-line clones is substantially rescued by expression of hep^CA.Scer\UAS under the control of Scer\GAL4^hs.PB using heat shock.

(Chen et al., 2002)

Xenogenetic Interactions

Statement

Reference

The formation of giant syncytia in the patches of dorsal larval epidermis expressing hep^CA.Scer\UAS under the control of Scer\GAL4^pnr-MD237 (using tub-Gal80ts to limit the expression to 16 hr-long pulse during the third instar) is not suppressed by co-expression of BacA\p35^Scer\UAS.cUa, the number of nuclei within the syncytia is also not changed.

(Wang et al., 2015)

Expression of Zzzz\E4orf4^Scer\UAS.cPa has little effect on the reduced eclosion rates seen when hep^CA.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF at 18[o]C. However at 24[o]C the reduced eclosion rate is partially suppressed, with 89% of flies eclosing (compared to 0.75% when hep^CA.Scer\UAS is expressed alone).

Expression of Zzzz\E4orf4^Scer\UAS.cPa partially rescues the eye phenotypes seen when hep^CA.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF at 18[o]C. Eye size is restored to 25% and 31% of controls in females and males respectively (from 17% and 18%).

(Pechkovsky et al., 2013)

Co-expression of Zzzz\lef^Scer\UAS.cGa with hep^CA.Scer\UAS under the control of Scer\GAL4^CY2 driver almost completely suppresses the hep^CA.Scer\UAS partial loss of the fifth longitudinal vein (L5) phenotype, indicating that Zzzz\lef acts in parallel to or downstream of hep.

(Guichard et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6406

y¹ w¹¹¹⁸; P{UAS-hep.CA}4

58781

y¹ w^*; P{UAS-hep.CA}2/SM1