FlyBase Allele Report: Dmel\Pak[3]

General Information

Symbol

Dmel\Pak³

Species

D. melanogaster

Name

FlyBase ID

FBal0098345

Feature type

allele

Associated gene

Dmel\Pak

Associated Insertion(s)

Carried in Construct

Also Known As

dPak³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: G569D. This mutation is in the kinase domain.

(Hing et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,358,916..6,358,916 [+]

Nucleotide change:

G6358916A

Amino acid change:

Reported amino acid change:

G569D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hing et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage | recessive

(Hing et al., 1999)

some die during pharate adult stage | recessive

(Hing et al., 1999)

uncoordinated

(Hing et al., 1999)

Phenotype Manifest In

bouton (with Pak⁶)

(Albin and Davis, 2004)

wing

(Hing et al., 1999)

Detailed Description

Statement

Reference

Pak³/Df(3R)WIN11 mutants exhibit a decrease in the EPSP and mEPSP half-width compared to wild-type and Df(3R)WIN11/+ only controls.

(Albin and Davis, 2004)

Adult escapers are uncoordinated and have crumpled wings but are otherwise wild type in appearance.

(Hing et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pak[+]/Pak³ is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of dbo^henji-1/dbo^henji-8

(Wang et al., 2016)

Other

Statement

Reference

GluRIIA^SP16, Pak³/Pak⁶ has abnormal neurophysiology phenotype

(Albin and Davis, 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

Pak[+]/Pak³ is a suppressor | partially of bouton | third instar larval stage phenotype of dbo^henji-1/dbo^henji-8

(Wang et al., 2016)

Pak[+]/Pak³ is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of dbo^henji-1/dbo^henji-8

(Wang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Pak³/+ partially suppresses the increased satellite bouton phenotype seen in dbo^henji-1/dbo^henji-8 mutant larval neuromuscular junctions.

(Wang et al., 2016)

GluRIIA^SP16; Pak⁶/Pak³ mutants exhibit a statistically significant decrease in synaptic quantal size compared to wild-type. This is also a statistically significant decrease compared to GluRIIA^SP16. GluRIIA^SP16; Pak⁶/Pak³ mutants exhibit a significant increase in quantal content compared to controls, indicating homeostatic compensation.

(Albin and Davis, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pak³

dPak³

(Lee and Schwarz, 2016)

dpak³

(Wang et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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