Created by a 4kb foldback (FB) insertion into the catalytic domain of PTP-ER, just downstream of the invariant aspartate residue on the WPD loop. The insertion also generates a 9bp duplication (TCATCACTC) at its insertion site. The insertion creates a stop codon, terminating the PTP-ER 14 residues into the insertion.
PTP-ERXE-3022/PTP-ERXE-2776 do not show synthetic lethality when placed in an alphS-331 homozygous background, however, a significant increase of extra R7 cells is observed compared to the respective single homozygotes.
Dominant enhancer of the Ras85DV12.sev rough eye phenotype. Heterozygous PTP-ERXE-3022 suppresses the rough eyes and loss of photoreceptor cells seen in either hemizygous Dsor1XS520, hemizygous phl12 or homozygous ksrS-548. Ectopic expression of PTP-ERhs.sev in the eye completely blocks the Ras85DV12.sev rough eye phenotype even in the presence of PTP-ERXE-3022.