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General Information
Symbol
Dmel\PTP-ERXE-3022
Species
D. melanogaster
Name
FlyBase ID
FBal0098354
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Created by a 4kb foldback (FB) insertion into the catalytic domain of PTP-ER, just downstream of the invariant aspartate residue on the WPD loop. The insertion also generates a 9bp duplication (TCATCACTC) at its insertion site. The insertion creates a stop codon, terminating the PTP-ER 14 residues into the insertion.

Insertion components
FB{}PTP-ERXE-3022
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

PTP-ERXE-3022 flies have a rough eye phenotype due to ommatidia occasionally containing one or more extra R7 cells, which may be accompanied by loss of an outer photoreceptor cell. R3 and R4 cells are unaffected.

Displays a very mild eye roughness due to the recruitment of ectopic R7 cells either when homozygous or when hemizygous with a deficiency for the 57F--58A region.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

PTP-ER[+]/PTP-ERXE-3022 is an enhancer of visible phenotype of Mkp31/Mkp32, Scer\GAL4[-]

Suppressor of
Statement
Reference

PTP-ERXE-3022 is a suppressor of visible | recessive phenotype of ksrS-548

PTP-ERXE-3022 is a suppressor of visible | recessive phenotype of Raf12

Other
Phenotype Manifest In
Enhanced by
Suppressed by
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

PTP-ERXE-3022 is a non-enhancer of ommatidium phenotype of Mkp31/Mkp32

Suppressor of
Statement
Reference

PTP-ERXE-3022 is a suppressor of eye phenotype of Raf12

PTP-ERXE-3022 is a suppressor of ommatidium phenotype of Raf12

PTP-ERXE-3022 is a suppressor of ommatidium phenotype of Dsor1XS520

PTP-ERXE-3022 is a suppressor of eye phenotype of Dsor1XS520

PTP-ERXE-3022 is a suppressor of eye phenotype of ksrS-548

PTP-ERXE-3022 is a suppressor of ommatidium phenotype of ksrS-548

NOT Suppressor of
Statement
Reference

PTP-ERXE-3022 is a non-suppressor of ommatidium phenotype of Mkp31/Mkp32

Additional Comments
Genetic Interactions
Statement
Reference

PTP-ERXE-3022, in a double homozygote combination with alphS-331 exhibits a synthetic lethality.

PTP-ERXE-3022/PTP-ERXE-2776 do not show synthetic lethality when placed in an alphS-331 homozygous background, however, a significant increase of extra R7 cells is observed compared to the respective single homozygotes.

PTP-ERXE-3022 ; Mkp31/Mkp32 pharate adults have ommatidia characteristic of either single mutant.

Dominant enhancer of the Ras85DV12.sev rough eye phenotype. Heterozygous PTP-ERXE-3022 suppresses the rough eyes and loss of photoreceptor cells seen in either hemizygous Dsor1XS520, hemizygous phl12 or homozygous ksrS-548. Ectopic expression of PTP-ERhs.sev in the eye completely blocks the Ras85DV12.sev rough eye phenotype even in the presence of PTP-ERXE-3022.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)