Allele Dmel\PTP-ER^XE-2776

General Information
Symbol	Dmel\PTP-ER^XE-2776	Species	D. melanogaster
Name		FlyBase ID	FBal0098355
Feature type	allele	Associated gene	Dmel\PTP-ER

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Inversion breakpoint in the catalytic domain of PTP-ER. (Karim and Rubin, 1999)
Caused by aberration	In(2R)XE-2776 (Karim and Rubin, 1999)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Karim and Rubin, 1999) visible \| recessive (Karim and Rubin, 1999)
Phenotype Manifest In
	eye (Karim and Rubin, 1999) eye photoreceptor cell (Karim and Rubin, 1999) ommatidium (Karim and Rubin, 1999) photoreceptor cell R7 \| ectopic (Karim and Rubin, 1999)
Detailed Description
	Statement Reference Displays a very mild eye roughness due to the recruitment of ectopic R7 cells when hemizygous with a deficiency for the 57F--58A region. (Karim and Rubin, 1999)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference PTP-ER^XE-2776 is an enhancer of visible phenotype of Ras85D^V12.sev (Karim and Rubin, 1999)
Suppressor of
Statement Reference PTP-ER^XE-2776 is a suppressor \| partially of lethal phenotype of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^elav-C155 (Maher et al., 2011) PTP-ER^XE-2776 is a suppressor of visible \| recessive phenotype of ksr^S-548 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of visible \| recessive phenotype of phl¹² (Karim and Rubin, 1999)
Phenotype Manifest In
Enhanced by
Statement Reference PTP-ER^XE-3022/PTP-ER^XE-2776 has photoreceptor cell R7 \| supernumerary phenotype, enhanceable by alph^S-331 (Baril and Therrien, 2006)
Enhancer of
Statement Reference PTP-ER^XE-2776 is an enhancer of eye phenotype of Ras85D^V12.sev (Karim and Rubin, 1999) PTP-ER^XE-2776 is an enhancer of ommatidium phenotype of Ras85D^V12.sev (Karim and Rubin, 1999) PTP-ER^XE-3022/PTP-ER^XE-2776 is an enhancer of photoreceptor cell R7 \| supernumerary phenotype of alph^S-331 (Baril and Therrien, 2006)
Suppressor of
Statement Reference PTP-ER^XE-2776 is a suppressor \| partially of eye photoreceptor cell phenotype of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^elav-C155 (Maher et al., 2011) PTP-ER^XE-2776 is a suppressor of eye phenotype of Dsor1^XS520 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of eye phenotype of ksr^S-548 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of eye phenotype of phl¹² (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of eye photoreceptor cell phenotype of Dsor1^XS520 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of Dsor1^XS520 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of ksr^S-548 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of ommatidium phenotype of phl¹² (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of photoreceptor cell phenotype of ksr^S-548 (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of photoreceptor cell phenotype of phl¹² (Karim and Rubin, 1999) PTP-ER^XE-2776 is a suppressor of photoreceptor cell R7 phenotype of Dsor1^XS520 (Karim and Rubin, 1999)
Additional Comments
Genetic Interactions
Statement Reference PTP-ER^XE-3022/PTP-ER^XE-2776 do not show synthetic lethality when placed in an alph^S-331 homozygous background, however, a significant increase of extra R7 cells is observed compared to the respective single homozygotes. (Baril and Therrien, 2006) Enhancer of the Ras85D^V12.sev rough eye phenotype. Heterozygous PTP-ER^XE-2776 suppresses the rough eyes and loss of photoreceptor cells seen in either hemizygous Dsor1^XS520, hemizygous phl¹² or homozygous ksr^S-548. (Karim and Rubin, 1999)
Xenogenetic Interactions
Statement Reference The neuronal degeneration phenotype and decreased survival of animals expressing Hsap\HD[Q93.ex1p.Scer\UAS] under the control of Scer\GAL4[elav-C155] is partially suppressed in a PTP-ER[XE-2776]/+ background. (Maher et al., 2011)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	5765 In(2R)XE-2776, PTP-ER^XE-2776/CyO, P{sevRas1.V12}FK1
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	PTP-ER^XE-2776 (Baril and Therrien, 2006, Maher et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Baril and Therrien, 2006, Dev. Biol. 294(1): 232--245 Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. [FBrf0190087] Karim and Rubin, 1999, Mol. Cell 3(6): 741--750 PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development. [FBrf0108829]

Allele Dmel\PTP-ERXE-2776

Allele Dmel\PTP-ER^XE-2776